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| Target General Information |
Top |
| Target ID |
T04773 |
Target Info
|
| Target Name |
Stromal cell-derived factor 1 (CXCL12) |
| Synonyms |
hSDF-1; SDF1B; SDF1A; SDF1; SDF-1; Pre-B cell growth-stimulating factor; Pre-B cell growth stimulating factor; PBSF; Intercrine reduced in hepatomas; IRH; HIRH; C-X-C motif chemokine 12 |
| Target Type |
Clinical trial Target |
| Gene Name |
CXCL12 |
| Biochemical Class |
Cytokine: CXC chemokine |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| G-protein-coupled receptors |
[+] 1 G-protein-coupled receptors |
+ |
| Interacting Target Name |
C-X-C chemokine receptor type 4 (CXCR4) |
Successful Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Stromal cell-derived factor 1 receptor; SDF-1 receptor; NPYRL; LPS-associated protein 3; Lipopolysaccharide-associated protein 3; Leukocyte-derived seven transmembrane domain receptor; LESTR; LCR1; LAP-3; HM89; Fusin; FB22; CXC-R4; CXCR-4; Chemokine receptor CXCR4; CD184 antigen; CD184 |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Co-crystal Structure |
[2] |
| References |
Top |
| REF 1 |
High-Mobility Group Box-1 Modulates the Expression of Inflammatory and Angiogenic Signaling Pathways in Diabetic Retina. Curr Eye Res. 2015;40(11):1141-52.
|
| REF 2 |
The CXC chemokine receptor 4 ligands ubiquitin and stromal cell-derived factor-1 function through distinct receptor interactions. J Biol Chem. 2011 Sep 23;286(38):33466-77.
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