Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T11211 Target Info
Target Name Androgen receptor (AR)
Synonyms Testosterone receptor; Nuclear receptor subfamily 3 group C member 4; NR3C4; Dihydrotestosterone receptor; DHTR
Target Type Successful Target
Gene Name AR
Biochemical Class Nuclear hormone receptor
UniProt ID
ANDR_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 2 Acid anhydride hydrolases +
Interacting Target Name Mitotic growth and transcription activator (BAF190A) Literature-reported Target Interacting Protein Info
UniProt ID
SMCA4_HUMAN 
Synonyms Transcription activator BRG1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; SNF2L4; SNF2-beta; SNF2B; Protein BRG-1; Protein brahma homolog 1; BRG1-associated factor 190A; BRG1; ATP-dependent helicase SMARCA4
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Proximity Label-MS [2]
3 Yeast two hybrid [3]
Interacting Protein Name Probable global transcription activator SNF2L2 (SMARCA2) Interacting Protein Interacting Protein Info
UniProt ID
SMCA2_HUMAN 
Synonyms BAF190; BRM; NCBRS; SNF2; SNF2L2; SNF2LA; SWI2; Sth1p; hBRM; hSNF2a
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Proximity Label-MS [2]
3 Yeast two hybrid [3]
Acyltransferases [+] 10 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase RNF14 (RNF14) Interacting Protein Interacting Protein Info
UniProt ID
RNF14_HUMAN 
Synonyms ARA54; HFB30; TRIAD2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Protein-peptide [6]
3 Reconstituted Complex [7]
4 Yeast two hybrid [6]
Interacting Target Name Nuclear receptor coactivator 3 (NCOA3) Literature-reported Target Interacting Protein Info
UniProt ID
NCOA3_HUMAN 
Synonyms TRAM-1; TRAM1; Thyroid hormone receptor activator molecule 1; Steroid receptor coactivator protein 3; SRC-3; Receptor-associated coactivator 3; RAC-3; RAC3; PCIP; NCoA-3; Class E basic helix-loop-helix protein 42; CBP-interacting protein; bHLHe42; Amplified in breast cancer-1 protein; Amplified in breast cancer 1 protein; AIB1 (SRC-3); AIB-1; AIB1; ACTR
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Reconstituted Complex [9]
3 Yeast two hybrid [9]
Interacting Target Name E3 ubiquitin-protein ligase RNF6 (RNF6) Literature-reported Target Interacting Protein Info
UniProt ID
RNF6_HUMAN 
Synonyms SPG2; RING-type E3 ubiquitin transferase RNF6
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Co-localization [11]
3 Reconstituted Complex [10]
Interacting Protein Name E3 ubiquitin-protein ligase CHIP (STUB1) Interacting Protein Interacting Protein Info
UniProt ID
CHIP_HUMAN 
Synonyms CHIP; HSPABP2; NY.CO.7; SCAR16; SDCCAG7; UBOX1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Reconstituted Complex [13]
3 Yeast two hybrid [14]
Interacting Protein Name Nuclear receptor coactivator 1 (NCOA1) Interacting Protein Interacting Protein Info
UniProt ID
NCOA1_HUMAN 
Synonyms F.SRC.1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Reconstituted Complex [16]
3 Yeast two hybrid [17]
Interacting Protein Name E3 ubiquitin-protein ligase RNF4 (RNF4) Interacting Protein Interacting Protein Info
UniProt ID
RNF4_HUMAN 
Synonyms SLX5; SNURF
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Reconstituted Complex [19]
3 Yeast two hybrid [19]
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Biochemical Activity [21]
Interacting Target Name Tripartite motif-containing 24 (TRIM24) Literature-reported Target Interacting Protein Info
UniProt ID
TIF1A_HUMAN 
Synonyms Tripartite motif-containing protein 24; Transcription intermediary factor 1-alpha; TIF1-alpha; TIF1A; TIF1; RNF82; RING-type E3 ubiquitin transferase TIF1-alpha; RING finger protein 82; E3 ubiquitin-protein ligase TRIM24
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [22]
2 Reconstituted Complex [23]
Interacting Target Name Renal carcinoma antigen NY-REN-54 (UBE3A) Literature-reported Target Interacting Protein Info
UniProt ID
UBE3A_HUMAN 
Synonyms Ubiquitin-protein ligase E3A; Oncogenic protein-associated protein E6-AP; Human papillomavirus E6-associated protein; HPVE6A; HECT-type ubiquitin transferase E3A; EPVE6AP; E6AP ubiquitin-protein ligase; E6AP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [24]
2 Biochemical Activity [25]
Interacting Protein Name RING finger and CHY zinc finger domain-containing protein 1 (RCHY1) Interacting Protein Interacting Protein Info
UniProt ID
ZN363_HUMAN 
Synonyms ARNIP; CHIMP; PIRH2; PRO1996; RNF199; ZCHY; ZNF363
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [26]
2 Yeast two hybrid [27]
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name Hydrogen peroxide-inducible clone 5 protein (TGFB1I1) Interacting Protein Interacting Protein Info
UniProt ID
TGFI1_HUMAN 
Synonyms ARA55; HIC.5; HIC5; TSC.5
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [28]
2 Protein-peptide [6]
3 Reconstituted Complex [28]
4 Yeast two hybrid [28]
Beta-transducin repeats [+] 1 Beta-transducin repeats +
Interacting Protein Name DNA damage-binding protein 2 (DDB2) Interacting Protein Interacting Protein Info
UniProt ID
DDB2_HUMAN 
Synonyms DDBB; UV.DDB2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [29]
2 Reconstituted Complex [30]
Carbon-nitrogen hydrolases [+] 3 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [31]
2 Yeast two hybrid [32]
Interacting Target Name Histone deacetylase 4 (HDAC4) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC4_HUMAN 
Synonyms KIAA0288; HD4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [33]
2 Reconstituted Complex [34]
Interacting Target Name Histone deacetylase 3 (HDAC3) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC3_HUMAN 
Synonyms SMAP45; RPD3-2; RPD32; HD3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [35]
2 Reconstituted Complex [34]
Cell cycle related proteins [+] 1 Cell cycle related proteins +
Interacting Target Name G1/S-specific cyclin-D1 (CCND1) Clinical trial Target Interacting Protein Info
UniProt ID
CCND1_HUMAN 
Synonyms PRAD1 oncogene; PRAD1; Cyclin D1; BCL-1 oncogene; BCL-1; BCL1; B-cell lymphoma 1 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [36]
2 Reconstituted Complex [36]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [37]
2 Reconstituted Complex [38]
3 Yeast two hybrid [16]
Kinases [+] 3 Kinases +
Interacting Protein Name Serine/threonine-protein kinase PAK 6 (PAK6) Interacting Protein Interacting Protein Info
UniProt ID
PAK6_HUMAN 
Synonyms PAK5
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [39]
2 Reconstituted Complex [40]
3 Yeast two hybrid [39]
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [41]
2 Reconstituted Complex [41]
Interacting Target Name Cyclin-dependent kinase 7 (CDK7) Clinical trial Target Interacting Protein Info
UniProt ID
CDK7_HUMAN 
Synonyms TFIIH basal transcription factor complex kinase subunit; Serine/threonine-protein kinase 1; P39 Mo15; MO15; Cell division protein kinase 7; CDKN7; CDK-activating kinase 1; CDK-activating kinase; CAK1; CAK; 39 kDa protein kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [42]
2 Reconstituted Complex [42]
One-carbon transferases [+] 2 One-carbon transferases +
Interacting Target Name Lysine N-methyltransferase 3B (NSD1) Literature-reported Target Interacting Protein Info
UniProt ID
NSD1_HUMAN 
Synonyms Nuclear receptor-binding SET domain-containing protein 1; NR-binding SET domain-containing protein; NR-binding SET domain containing protein; KMT3B; Hypothetical protein FLJ22263 similar to nuclear receptor-binding SET-domain protein 1; Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific; H4-K20-HMTase; H3-K36-HMTase; ARA267; Androgen receptor-associated protein of 267 kDa; Androgen receptor-associated coregulator 267; Androgen receptor coactivator 267 kDa protein; Androgen receptor associated coregulator 267
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [43]
2 Yeast two hybrid [44]
Interacting Protein Name Histone-lysine N-methyltransferase 2D (KMT2D) Interacting Protein Interacting Protein Info
UniProt ID
KMT2D_HUMAN 
Synonyms AAD10; ALR; CAGL114; KABUK1; KMS; MLL2; MLL4; TNRC21
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [45]
2 Proximity Label-MS [2]
Oxidoreductases [+] 2 Oxidoreductases +
Interacting Protein Name Probable JmjC domain-containing histone demethylation protein 2C (JMJD1C) Interacting Protein Interacting Protein Info
UniProt ID
JHD2C_HUMAN 
Synonyms TRIP8
Evidence Score (E-score) 3 Experimental Evidences +
1 Proximity Label-MS [2]
2 Reconstituted Complex [16]
3 Yeast two hybrid [16]
Interacting Target Name Lysine-specific histone demethylase 1 (LSD) Clinical trial Target Interacting Protein Info
UniProt ID
KDM1A_HUMAN 
Synonyms Lysine-specific histone demethylase 1A; Lysinespecific histone demethylase 1A; LSD1; KIAA0601; KDM1; Flavin-containing amine oxidase domain-containing protein 2; Flavincontaining amine oxidase domaincontaining protein 2; BRAF35-HDAC complex protein BHC110; BRAF35HDAC complex protein BHC110; AOF2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [46]
2 Proximity Label-MS [2]
Transcription regulators [+] 10 Transcription regulators +
Interacting Protein Name Nuclear receptor corepressor 2 (NCOR2) Interacting Protein Interacting Protein Info
UniProt ID
NCOR2_HUMAN 
Synonyms CTG26; N.CoR2; SMAP270; SMRT; SMRTE; SMRTE.tau; TNRC14; TRAC; TRAC.1; TRAC1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [47]
2 Co-localization [47]
3 Proximity Label-MS [2]
4 Reconstituted Complex [47]
5 Yeast two hybrid [47]
Interacting Protein Name Nuclear receptor coactivator 2 (NCOA2) Interacting Protein Interacting Protein Info
UniProt ID
NCOA2_HUMAN 
Synonyms GRIP1; KAT13C; NCoA.2; SRC2; TIF2; bHLHe75
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Protein-peptide [48]
3 Reconstituted Complex [49]
4 Yeast two hybrid [50]
Interacting Protein Name Nuclear receptor corepressor 1 (NCOR1) Interacting Protein Interacting Protein Info
UniProt ID
NCOR1_HUMAN 
Synonyms N.CoR; N.CoR1; PPP1R109; TRAC1; hN.CoR
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [51]
2 Proximity Label-MS [2]
3 Reconstituted Complex [51]
4 Yeast two hybrid [51]
Interacting Target Name Mothers against decapentaplegic homolog 3 (SMAD3) Successful Target Interacting Protein Info
UniProt ID
SMAD3_HUMAN 
Synonyms TGF-beta response effector Smad3; Smad3; SMAD family member 3; SMAD 3; Mothers against DPP homolog 3; MMad3; MADH3; Mad3; MAD homolog 3; JV15-2; HSMAD3; HMAD-3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [52]
2 Reconstituted Complex [53]
3 Yeast two hybrid [53]
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [54]
2 Reconstituted Complex [55]
3 Yeast two hybrid [56]
Interacting Protein Name Paired box protein Pax-6 (PAX6) Interacting Protein Interacting Protein Info
UniProt ID
PAX6_HUMAN 
Synonyms AN; AN2; D11S812E; FVH1; MGDA; WAGR
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [57]
2 Fluorescence Resonance Energy Transfer [58]
3 Reconstituted Complex [58]
Interacting Protein Name Transcription factor 20 (TCF20) Interacting Protein Interacting Protein Info
UniProt ID
TCF20_HUMAN 
Synonyms AR1; SPBP; TCF.20
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [58]
2 Proximity Label-MS [2]
3 Reconstituted Complex [58]
Interacting Target Name Signal transducer and activator of transcription 3 (STAT3) Successful Target Interacting Protein Info
UniProt ID
STAT3_HUMAN 
Synonyms Transcription factor STAT3; Stat3; Signal transducer and activator of transcription 3; APRF; Acute-phase response factor
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [59]
2 Reconstituted Complex [60]
Interacting Protein Name SWI/SNF complex subunit SMARCC1 (SMARCC1) Interacting Protein Interacting Protein Info
UniProt ID
SMRC1_HUMAN 
Synonyms BAF155; CRACC1; Rsc8; SRG3; SWI3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Proximity Label-MS [2]
Interacting Protein Name BRG1-associated factor 60A (SMARCD1) Interacting Protein Interacting Protein Info
UniProt ID
SMRD1_HUMAN 
Synonyms BAF60A; CRACD1; Rsc6p
Evidence Score (E-score) 2 Experimental Evidences +
1 Proximity Label-MS [2]
2 Yeast two hybrid [3]
Ubiquitin related proteins [+] 2 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [37]
2 Reconstituted Complex [13]
Interacting Target Name Tumor susceptibility gene protein 101 (TSG101) Clinical trial Target Interacting Protein Info
UniProt ID
TS101_HUMAN 
Synonyms Tumor susceptibility gene 101 protein; ESCRT-I complex subunit TSG101
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [61]
2 Yeast two hybrid [62]
Other proteins [+] 8 Other proteins +
Interacting Target Name Nuclear receptor coactivator 4 (NCOA4) Literature-reported Target Interacting Protein Info
UniProt ID
NCOA4_HUMAN 
Synonyms RFG; Ret-activating protein ELE1; Nuclear receptor coactivator 4; NCoA-4; ELE1; ARA70 (dARA70N); ARA70; Androgen receptor-associated protein of 70 kDa; Androgen receptor coactivator 70 kDa protein; 70 kDa AR-activator; 70 kDa androgen receptor coactivator
Evidence Score (E-score) 4 Experimental Evidences +
1 Far Western [63]
2 Protein-peptide [6]
3 Reconstituted Complex [63]
4 Yeast two hybrid [64]
Interacting Protein Name Melanoma-associated antigen 11 (MAGEA11) Interacting Protein Interacting Protein Info
UniProt ID
MAGAB_HUMAN 
Synonyms CT1.11; MAGE.11; MAGE11; MAGEA.11
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [65]
2 Co-localization [65]
3 Reconstituted Complex [65]
4 Yeast two hybrid [65]
Interacting Target Name Beta-catenin (CTNNB1) Successful Target Interacting Protein Info
UniProt ID
CTNB1_HUMAN 
Synonyms Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [66]
2 Reconstituted Complex [66]
3 Yeast two hybrid [17]
Interacting Protein Name Non-POU domain-containing octamer-binding protein (NONO) Interacting Protein Interacting Protein Info
UniProt ID
NONO_HUMAN 
Synonyms NMT55; NRB54; P54; P54NRB; PPP1R114
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [49]
2 Affinity Capture-Western [49]
3 Reconstituted Complex [49]
Interacting Protein Name Speckle-type POZ protein (SPOP) Interacting Protein Interacting Protein Info
UniProt ID
SPOP_HUMAN 
Synonyms BTBD32; TEF2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [67]
2 Reconstituted Complex [67]
3 Yeast two hybrid [3]
Interacting Target Name von Hippel-Lindau disease tumor suppressor (VHL) Patented-recorded Target Interacting Protein Info
UniProt ID
VHL_HUMAN 
Synonyms pVHL; Protein G7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [68]
2 Reconstituted Complex [69]
Interacting Protein Name DDB1- and CUL4-associated factor 6 (DCAF6) Interacting Protein Interacting Protein Info
UniProt ID
DCAF6_HUMAN 
Synonyms 1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP; PC326
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [70]
2 Yeast two hybrid [70]
Interacting Protein Name BRG1-associated factor 57 (SMARCE1) Interacting Protein Interacting Protein Info
UniProt ID
SMCE1_HUMAN 
Synonyms BAF57
Evidence Score (E-score) 2 Experimental Evidences +
1 Proximity Label-MS [2]
2 Reconstituted Complex [71]
References  Top
REF 1 Mechanistic relationship between androgen receptor polyglutamine tract truncation and androgen-dependent transcriptional hyperactivity in prostate cancer cells. J Biol Chem. 2004 Apr 23;279(17):17319-28.
REF 2 Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping. Mol Cell Proteomics. 2017 Aug;16(8):1462-1474.
REF 3 Functional screening of FxxLF-like peptide motifs identifies SMARCD1/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression. Mol Endocrinol. 2009 Nov;23(11):1776-86.
REF 4 Prohibitin and the SWI/SNF ATPase subunit BRG1 are required for effective androgen antagonist-mediated transcriptional repression of androgen receptor-regulated genes. Carcinogenesis. 2008 Sep;29(9):1725-33.
REF 5 Suppression of androgen receptor transactivation and prostate cancer cell growth by heterogeneous nuclear ribonucleoprotein A1 via interaction with androgen receptor coregulator ARA54. Endocrinology. 2007 Mar;148(3):1340-9.
REF 6 The FXXLF motif mediates androgen receptor-specific interactions with coregulators. J Biol Chem. 2002 Mar 22;277(12):10226-35.
REF 7 Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor. J Biol Chem. 1999 Mar 26;274(13):8570-6.
REF 8 Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer. Br J Cancer. 2001 Dec 14;85(12):1928-36.
REF 9 Thyroid receptor activator molecule, TRAM-1, is an androgen receptor coactivator. Endocrinology. 2000 Sep;141(9):3440-50.
REF 10 Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination. Cancer Cell. 2009 Apr 7;15(4):270-82.
REF 11 Ring Finger Protein 6 Mediates Androgen-Induced Granulosa Cell Proliferation and Follicle Growth via Modulation of Androgen Receptor Signaling. Endocrinology. 2017 Apr 1;158(4):993-1004.
REF 12 The neuroendocrine-derived peptide parathyroid hormone-related protein promotes prostate cancer cell growth by stabilizing the androgen receptor. Cancer Res. 2009 Sep 15;69(18):7402-11.
REF 13 The phosphorylation of the androgen receptor by TFIIH directs the ubiquitin/proteasome process. EMBO J. 2011 Feb 2;30(3):468-79.
REF 14 An androgen receptor NH2-terminal conserved motif interacts with the COOH terminus of the Hsp70-interacting protein (CHIP). J Biol Chem. 2004 Jul 16;279(29):30643-53.
REF 15 Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells. J Biol Chem. 2002 Oct 11;277(41):38087-94.
REF 16 A novel variant of the putative demethylase gene, s-JMJD1C, is a coactivator of the AR. Arch Biochem Biophys. 2007 Apr 1;460(1):56-66.
REF 17 Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells. Mol Endocrinol. 2004 Oct;18(10):2388-401.
REF 18 PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription. J Biol Chem. 2002 Feb 1;277(5):3280-5.
REF 19 Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription. Mol Cell Biol. 1998 Sep;18(9):5128-39.
REF 20 p300 acetyltransferase regulates androgen receptor degradation and PTEN-deficient prostate tumorigenesis. Cancer Res. 2014 Mar 15;74(6):1870-1880.
REF 21 p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation. J Biol Chem. 2000 Jul 7;275(27):20853-60.
REF 22 TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells. Biochim Biophys Acta. 2009 Dec;1793(12):1828-36.
REF 23 Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1. J Biol Chem. 1997 May 2;272(18):12062-8.
REF 24 Multifunction steroid receptor coactivator, E6-associated protein, is involved in development of the prostate gland. Mol Endocrinol. 2006 Mar;20(3):544-59.
REF 25 Identification of a novel K311 ubiquitination site critical for androgen receptor transcriptional activity. Nucleic Acids Res. 2017 Feb 28;45(4):1793-1804.
REF 26 Ubiquitylation of epsilon-COP by PIRH2 and regulation of the secretion of PSA. Mol Cell Biochem. 2008 Jan;307(1-2):73-82.
REF 27 Cloning and characterization of an androgen receptor N-terminal-interacting protein with ubiquitin-protein ligase activity. J Mol Endocrinol. 2002 Aug;29(1):41-60.
REF 28 Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator. J Biol Chem. 2002 May 3;277(18):15426-31.
REF 29 DDB2 is a novel AR interacting protein and mediates AR ubiquitination/degradation. Int J Biochem Cell Biol. 2012 Nov;44(11):1952-61.
REF 30 NRIP/DCAF6 stabilizes the androgen receptor protein by displacing DDB2 from the CUL4A-DDB1 E3 ligase complex in prostate cancer. Oncotarget. 2017 Mar 28;8(13):21501-21515.
REF 31 Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylation. Nucleic Acids Res. 2005 Jan 7;33(1):13-26.
REF 32 Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor. J Biol Chem. 2002 Jul 19;277(29):25904-13.
REF 33 Inhibition of androgen receptor activity by histone deacetylase 4 through receptor SUMOylation. Oncogene. 2011 May 12;30(19):2207-18.
REF 34 Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase. Mol Cell Endocrinol. 2003 Aug 29;206(1-2):1-12.
REF 35 Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway. Cell. 2006 Feb 10;124(3):615-29.
REF 36 A central domain of cyclin D1 mediates nuclear receptor corepressor activity. Oncogene. 2005 Jan 13;24(3):431-44.
REF 37 Cooperative interactions between androgen receptor (AR) and heat-shock protein 27 facilitate AR transcriptional activity. Cancer Res. 2007 Nov 1;67(21):10455-65.
REF 38 Association of the 90-kDa heat shock protein does not affect the ligand-binding ability of androgen receptor. J Steroid Biochem Mol Biol. 1992 Sep;42(8):803-12.
REF 39 Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6. J Biol Chem. 2001 May 4;276(18):15345-53.
REF 40 AR and ER interaction with a p21-activated kinase (PAK6). Mol Endocrinol. 2002 Jan;16(1):85-99.
REF 41 Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7200-5.
REF 42 From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator. J Biol Chem. 2000 Mar 31;275(13):9308-13.
REF 43 Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells. J Biol Chem. 2001 Nov 2;276(44):40417-23.
REF 44 A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors. Nucleic Acids Res. 2013 Nov;41(21):9663-79.
REF 45 The mutational landscape of lethal castration-resistant prostate cancer. Nature. 2012 Jul 12;487(7406):239-43.
REF 46 CACUL1 functions as a negative regulator of androgen receptor in prostate cancer cells. Cancer Lett. 2016 Jul 1;376(2):360-6.
REF 47 Regulation of androgen receptor activity by the nuclear receptor corepressor SMRT. J Biol Chem. 2003 Feb 14;278(7):5052-61.
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REF 49 p54nrb acts as a transcriptional coactivator for activation function 1 of the human androgen receptor. Biochem Biophys Res Commun. 2003 Jul 4;306(3):660-5.
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