Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Lysine-specific histone demethylase 1 (LSD) | Clinical trial | Target Info | ||
| UniProt ID | KDM1A_HUMAN | ||||
| Gene Name | KDM1A | ||||
| Gene ID | 23028 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Histone deacetylase 1 (HDAC1) | Target Info | PPI Info | [1] | |
| Androgen receptor (AR) | Target Info | PPI Info | [2] | ||
| Interacting Clinical trial Target(s) | Histone deacetylase 2 (HDAC2) | Target Info | PPI Info | [3] | |
| Cellular tumor antigen p53 (TP53) | Target Info | PPI Info | [4] | ||
| Lysine-specific histone demethylase 1 (LSD) | Target Info | PPI Info | [3] | ||
| Histone deacetylase 3 (HDAC3) | Target Info | PPI Info | [5] | ||
| Interacting Literature-reported Target(s) | Metastasis associated gene-1 (MTA1) | Target Info | PPI Info | [6] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Dynamic regulation of histone H3 methylation at lysine 4 in mammalian spermatogenesis. Biol Reprod. 2007 Nov;77(5):754-64. | ||||
| REF 2 | CACUL1 functions as a negative regulator of androgen receptor in prostate cancer cells. Cancer Lett. 2016 Jul 1;376(2):360-6. | ||||
| REF 3 | A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. J Biol Chem. 2003 Feb 28;278(9):7234-9. | ||||
| REF 4 | p53-targeted LSD1 functions in repression of chromatin structure and transcription in vivo. Mol Cell Biol. 2008 Sep;28(17):5139-46. | ||||
| REF 5 | Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Nat Biotechnol. 2011 Mar;29(3):255-65. | ||||
| REF 6 | LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell. 2009 Aug 21;138(4):660-72. | ||||
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