Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T19579 | Target Info | |||
| Target Name | Interleukin 2 receptor beta (IL2RB) | ||||
| Synonyms | P70-75; Interleukin-2 receptor subunit beta; Interleukin-15 receptor subunit beta; IL15RB; IL-2RB; IL-2R subunit beta; IL-2 receptor subunit beta; IL-2 receptor; High affinity IL-2 receptor subunit beta; CD122 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | IL2RB | ||||
| Biochemical Class | Cytokine receptor | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Kinases | [+] 1 Kinases | + | |||
| Interacting Target Name | Janus kinase 1 (JAK-1) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Tyrosine-protein kinase JAK1; JAK1B; JAK1A | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| 3 | Affinity Capture-Western | [3] | |||
| 4 | Reconstituted Complex | [4] | |||
| Other proteins | [+] 1 Other proteins | + | |||
| Interacting Protein Name | Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | HRS | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [5] | |||
| 2 | Affinity Capture-Western | [6] | |||
| 3 | Reconstituted Complex | [6] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta. J Biol Chem. 1998 Apr 24;273(17):10719-25. | ||||
| REF 2 | Functional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylation. Mol Cell Biol. 1998 Nov;18(11):6416-22. | ||||
| REF 3 | Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor beta and gamma chains. Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7271-5. | ||||
| REF 4 | Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors. J Immunol. 2002 Aug 1;169(3):1302-8. | ||||
| REF 5 | Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain. J Cell Sci. 2008 May 15;121(Pt 10):1727-38. | ||||
| REF 6 | Hrs recognizes a hydrophobic amino acid cluster in cytokine receptors during ubiquitin-independent endosomal sorting. J Biol Chem. 2011 Apr 29;286(17):15458-72. | ||||
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