Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T21705 Target Info
Target Name F-box and WD-40 domain protein 7 (Fbxw7)
Synonyms hCdc4; hAgo; SEL10; SEL-10; FBX30; FBW7; F-box/WD repeat-containing protein 7; F-box-WD40 repeat protein 6; F-box protein Fbxw6; F-box protein FBX30; F-box protein FBW7; F-box and WD-40 domain-containing protein 7; Archipelago homolog
Target Type Literature-reported Target
Gene Name FBXW7
UniProt ID
FBXW7_HUMAN 
Target Interacting Proteins  Top
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Target Name Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) Clinical trial Target Interacting Protein Info
UniProt ID
MCL1_HUMAN 
Synonyms mcl1/EAT; Induced myeloid leukemia cell differentiation protein Mcl-1; Bcl-2-related protein EAT/mcl1; Bcl-2-like protein 3; Bcl2-L-3; BCL2L3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Co-localization [1]
Cell cycle related proteins [+] 1 Cell cycle related proteins +
Interacting Target Name G1/S-specific cyclin-E1 (CCNE1) Literature-reported Target Interacting Protein Info
UniProt ID
CCNE1_HUMAN 
Synonyms G1/S-specific cyclin E; Cyclin E; CCNE
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-peptide [2]
2 Reconstituted Complex [3]
Transcription regulators [+] 5 Transcription regulators +
Interacting Target Name Notch-1 receptor (NOTCH1) Clinical trial Target Interacting Protein Info
UniProt ID
NOTC1_HUMAN 
Synonyms Translocation-associated notch protein TAN-1; Translocationassociated notch protein TAN1; TAN1; Notch 1 intracellular domain; Notch 1; NICD; Neurogenic locus notch homolog protein 1; hN1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [5]
3 Protein-Fragment Complementation Assay [6]
4 Reconstituted Complex [7]
Interacting Target Name Transcription factor AP-1 (JUN) Discontinued Target Interacting Protein Info
UniProt ID
JUN_HUMAN 
Synonyms V-jun avian sarcoma virus 17 oncogene homolog; Transcription factor AP-1; Proto-oncogene c-jun; P39; C-jun proto-oncogene; AP-1 transcription factor; AP1; Activator protein-1; Activator protein 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Protein-peptide [8]
2 Reconstituted Complex [9]
3 Yeast two hybrid [8]
Interacting Target Name Proto-oncogene c-Myc (MYC) Literature-reported Target Interacting Protein Info
UniProt ID
MYC_HUMAN 
Synonyms Transcription factor p64; Proto-oncogene c-Myc; Myc proto-oncogene protein; C-myc oncogene; C-myc; Class E basic helix-loop-helix protein 39; bHLHe39
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [10]
2 Affinity Capture-Western [11]
3 Reconstituted Complex [11]
Interacting Target Name Nuclear factor NF-kappa-B (NFKB) Successful Target Interacting Protein Info
UniProt ID
NFKB2_HUMAN 
Synonyms Oncogene Lyt-10; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; Nuclear factor NF-kappa-Bp52 subunit; Nuclear factor NF-kappa-B p100 subunit; Lyt10; Lymphocyte translocation chromosome 10 protein; Lymphocyte translocation chromosome 10; H2TF1; DNA-binding factor KBF2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [12]
2 Affinity Capture-Western [13]
Interacting Target Name N-myc proto-oncogene protein (MYCN) Literature-reported Target Interacting Protein Info
UniProt ID
MYCN_HUMAN 
Synonyms N-myc; NMYC; Class E basic helix-loop-helix protein 37; bHLHe37
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Reconstituted Complex [15]
References  Top
REF 1 Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells. Cancer Res. 2017 May 1;77(9):2512-2521.
REF 2 Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase. J Biol Chem. 2004 Nov 26;279(48):50110-9.
REF 3 Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature. 2001 Sep 20;413(6853):316-22.
REF 4 NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function. Mol Cell. 2012 Nov 9;48(3):445-58.
REF 5 Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor. J Biol Chem. 2001 Sep 14;276(37):34371-8.
REF 6 Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor. BMC Cancer. 2016 May 26;16:335.
REF 7 MAGEA1 interacts with FBXW7 and regulates ubiquitin ligase-mediated turnover of NICD1 in breast and ovarian cancer cells. Oncogene. 2017 Aug 31;36(35):5023-5034.
REF 8 The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling. Science. 2004 Feb 27;303(5662):1374-8.
REF 9 Multivalent Interactions with Fbw7 and Pin1 Facilitate Recognition of c-Jun by the SCFFbw7 Ubiquitin Ligase. Structure. 2018 Jan 2;26(1):28-39.e2.
REF 10 Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. Cell Cycle. 2007 Jan 15;6(2):205-17.
REF 11 Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J. 2004 May 19;23(10):2116-25.
REF 12 A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat Cell Biol. 2004 Feb;6(2):97-105.
REF 13 Fbxw7- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma. Nat Cell Biol. 2012 Mar 4;14(4):375-85.
REF 14 Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma. Cancer Cell. 2009 Jan 6;15(1):67-78.
REF 15 Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13726-13731.

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