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| Protein General Information (TTD Target) |
Top |
| Full Name |
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
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Clinical trial
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Target Info
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| UniProt ID |
MCL1_HUMAN
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| Gene Name |
MCL1
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| Gene ID |
4170
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| Interacting TTD Target Information |
Top |
| Interacting Clinical trial Target(s) |
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) |
Target Info
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PPI Info
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[1] |
| Interacting Literature-reported Target(s) |
Apoptosis regulator BAK (BAK) |
Target Info
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PPI Info
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[2] |
| F-box and WD-40 domain protein 7 (Fbxw7) |
Target Info
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PPI Info
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[3] |
| References |
Top |
| REF 1 |
MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain. J Biol Chem. 2000 Aug 18;275(33):25255-61.
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| REF 2 |
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell. 2006 Nov;10(5):375-88.
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| REF 3 |
Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells. Cancer Res. 2017 May 1;77(9):2512-2521.
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