Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T22274 Target Info
Target Name Histone deacetylase 6 (HDAC6)
Synonyms KIAA0901; JM21; HD6
Target Type Clinical trial Target
Gene Name HDAC6
Biochemical Class Carbon-nitrogen hydrolase
UniProt ID
HDAC6_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 2 Acid anhydride hydrolases +
Interacting Target Name Endoplasmic reticulum chaperone BiP (HSPA5) Clinical trial Target Interacting Protein Info
UniProt ID
BIP_HUMAN 
Synonyms Immunoglobulin heavy chain-binding protein; Immunoglobulin heavy chainbinding protein; HSP70 family protein 5; Heat shock protein family A member 5; Heat shock protein 70 family protein 5; Heat shock 70 kDa protein 5; GRP-78; GRP78; Endoplasmic reticulum lumenal Ca(2+)binding protein grp78; BiP; Binding-immunoglobulin protein; 78 kDa glucose-regulated protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
Interacting Protein Name Myosin-10 (MYH10) Interacting Protein Interacting Protein Info
UniProt ID
MYH10_HUMAN 
Synonyms NMMHC.IIB; NMMHCB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [4]
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Biochemical Activity [6]
3 Reconstituted Complex [7]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name DNA mismatch repair protein MSH2 (MSH2) Literature-reported Target Interacting Protein Info
UniProt ID
MSH2_HUMAN 
Synonyms MutS protein homolog 2; Mismatch repair gene Msh2; hMSH2
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [8]
3 Affinity Capture-Western [8]
4 Biochemical Activity [8]
5 Co-fractionation [8]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [9]
3 Affinity Capture-Western [10]
4 Affinity Capture-Western [11]
5 Biochemical Activity [11]
Kinases [+] 2 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [12]
2 Affinity Capture-Western [13]
3 Protein-Fragment Complementation Assay [14]
4 Yeast two hybrid [15]
Interacting Target Name Protein kinase C alpha (PRKCA) Successful Target Interacting Protein Info
UniProt ID
KPCA_HUMAN 
Synonyms Protein kinase C alpha type; Protein Kinase C alpha; PRKACA; PKC-alpha; PKCalpha; PKC-A; PKCA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Biochemical Activity [16]
3 Reconstituted Complex [17]
Ribosomal proteins [+] 1 Ribosomal proteins +
Interacting Protein Name Small ribosomal subunit protein eS6 (RPS6) Interacting Protein Interacting Protein Info
UniProt ID
RS6_HUMAN 
Synonyms S6
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [18]
3 Co-fractionation [18]
4 Co-localization [18]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Affinity Capture-Western [20]
3 Affinity Capture-Western [21]
4 Affinity Capture-Western [22]
5 Reconstituted Complex [23]
6 Reconstituted Complex [4]
7 Reconstituted Complex [20]
Other proteins [+] 4 Other proteins +
Interacting Protein Name Tubulin alpha-1A chain (TUBA1A) Interacting Protein Interacting Protein Info
UniProt ID
TBA1A_HUMAN 
Synonyms B.ALPHA.1; LIS3; TUBA3
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [24]
3 Biochemical Activity [25]
4 Biochemical Activity [26]
5 Biochemical Activity [27]
Interacting Protein Name Src substrate cortactin (CTTN) Interacting Protein Interacting Protein Info
UniProt ID
SRC8_HUMAN 
Synonyms EMS1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [28]
2 Biochemical Activity [28]
3 Biochemical Activity [29]
Interacting Protein Name Tubulin alpha-1B chain (TUBA1B) Interacting Protein Interacting Protein Info
UniProt ID
TBA1B_HUMAN 
Synonyms K.ALPHA.1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [3]
3 Biochemical Activity [30]
Interacting Protein Name Tubulin beta chain (TUBB) Interacting Protein Interacting Protein Info
UniProt ID
TBB5_HUMAN 
Synonyms CDCBM6; M40; OK/SW.cl.56; TUBB1; TUBB5
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [3]
3 Affinity Capture-Western [24]
References  Top
REF 1 A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors. Cell Death Differ. 2013 Oct;20(10):1306-16.
REF 2 Treatment with panobinostat induces glucose-regulated protein 78 acetylation and endoplasmic reticulum stress in breast cancer cells. Mol Cancer Ther. 2010 Apr;9(4):942-52.
REF 3 HDAC6 activity is not required for basal autophagic flux in metastatic prostate cancer cells. Exp Biol Med (Maywood). 2016 Jun;241(11):1177-85.
REF 4 Influenza A virus uses the aggresome processing machinery for host cell entry. Science. 2014 Oct 24;346(6208):473-7.
REF 5 Acetylation of histone deacetylase 6 by p300 attenuates its deacetylase activity. Biochem Biophys Res Commun. 2009 May 22;383(1):88-92.
REF 6 Modulation of histone deacetylase 6 (HDAC6) nuclear import and tubulin deacetylase activity through acetylation. J Biol Chem. 2012 Aug 17;287(34):29168-74.
REF 7 P300 transcriptional repression is mediated by SUMO modification. Mol Cell. 2003 Apr;11(4):1043-54.
REF 8 HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutS. Mol Cell. 2014 Jul 3;55(1):31-46.
REF 9 HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling. J Biol Chem. 2009 Mar 20;284(12):7436-45.
REF 10 HDAC6 inhibition enhances 17-AAG--mediated abrogation of hsp90 chaperone function in human leukemia cells. Blood. 2008 Sep 1;112(5):1886-93.
REF 11 HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol Cell. 2005 May 27;18(5):601-7.
REF 12 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 13 The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation. J Biol Chem. 2010 Apr 9;285(15):11219-26.
REF 14 Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6. Sci Signal. 2009 Dec 22;2(102):ra84.
REF 15 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
REF 16 PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and -catenin. EMBO J. 2011 Sep 27;30(23):4838-49.
REF 17 Targeting MYC dependence in cancer by inhibiting BET bromodomains. Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16669-74.
REF 18 Histone deacetylase 6 associates with ribosomes and regulates de novo protein translation during arsenite stress. Toxicol Sci. 2012 May;127(1):246-55.
REF 19 Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin. J Mol Biol. 2007 Jul 6;370(2):290-302.
REF 20 Proteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chains. Mol Cell. 2013 Sep 26;51(6):819-28.
REF 21 Interferon-stimulated gene 15 (ISG15) and ISG15-linked proteins can associate with members of the selective autophagic process, histone deacetylase 6 (HDAC6) and SQSTM1/p62. J Biol Chem. 2015 Jan 16;290(3):1485-95.
REF 22 UCH-L1 Inhibition Suppresses tau Aggresome Formation during Proteasomal Impairment. Mol Neurobiol. 2018 May;55(5):3812-3821.
REF 23 The HDAC complex and cytoskeleton. Novartis Found Symp. 2004;259:170-7; discussion 178-81, 223-5.
REF 24 Histone deacetylase 6 (HDAC6) is an independent deacetylase for alpha-tubulin. Protein Pept Lett. 2010 May;17(5):555-8.
REF 25 HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. EMBO J. 2003 Mar 3;22(5):1168-79.
REF 26 In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation. EMBO J. 2002 Dec 16;21(24):6820-31.
REF 27 HDAC6 is a microtubule-associated deacetylase. Nature. 2002 May 23;417(6887):455-8.
REF 28 HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell. 2007 Jul 20;27(2):197-213.
REF 29 Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. EMBO J. 2011 Aug 16;30(20):4142-56.
REF 30 EGF-induced sodium influx regulates EGFR trafficking through HDAC6 and tubulin acetylation. BMC Cell Biol. 2015 Sep 18;16:24.

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