Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T26983 Target Info
Target Name Tumor suppressor p53-binding protein 1 (TP53BP1)
Synonyms p53BP1; p53-binding protein 1; TP53-binding protein 1; 53BP1
Target Type Literature-reported Target
Gene Name TP53BP1
UniProt ID
TP53B_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 2 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase RNF168 (RNF168) Interacting Protein Interacting Protein Info
UniProt ID
RN168_HUMAN 
Synonyms hRNF168
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Co-localization [2]
3 Co-localization [3]
Interacting Protein Name Breast cancer type 1 susceptibility protein (BRCA1) Interacting Protein Interacting Protein Info
UniProt ID
BRCA1_HUMAN 
Synonyms BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Co-localization [3]
Histones [+] 2 Histones +
Interacting Target Name Gamma-Histone H2AX (H2AFX) Literature-reported Target Interacting Protein Info
UniProt ID
H2AX_HUMAN 
Synonyms Phosphorylation of H2AX; Histone H2AX; Histone H2A.x; H2AX; H2a/x
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Co-localization [5]
3 Co-localization [6]
4 Co-localization [7]
5 Co-localization [8]
6 Protein-peptide [9]
Interacting Protein Name Histone H4 (H4) Interacting Protein Interacting Protein Info
UniProt ID
H4_HUMAN 
Synonyms H4FA
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-crystal Structure [10]
2 Protein-peptide [10]
3 Reconstituted Complex [11]
Kinases [+] 2 Kinases +
Interacting Target Name Polo-like kinase 1 (PLK1) Clinical trial Target Interacting Protein Info
UniProt ID
PLK1_HUMAN 
Synonyms STPK13; Serine-threonine protein kinase 13; Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase 13; PLK-1; Plk1; PLK; Mitoticserine-threonine kinase polo-like kinase 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [12]
2 Reconstituted Complex [12]
Interacting Target Name ATM serine/threonine kinase (ATM) Clinical trial Target Interacting Protein Info
UniProt ID
ATM_HUMAN 
Synonyms Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [9]
2 Reconstituted Complex [6]
Peptidases [+] 1 Peptidases +
Interacting Protein Name Ubiquitin carboxyl-terminal hydrolase 28 (USP28) Interacting Protein Interacting Protein Info
UniProt ID
UBP28_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [13]
2 Affinity Capture-Western [13]
3 Affinity Capture-Western [14]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Affinity Capture-Western [14]
3 Affinity Capture-Western [15]
4 Co-crystal Structure [16]
5 Co-localization [5]
6 Protein-peptide [16]
7 Reconstituted Complex [17]
Other proteins [+] 2 Other proteins +
Interacting Protein Name Mediator of DNA damage checkpoint protein 1 (MDC1) Interacting Protein Interacting Protein Info
UniProt ID
MDC1_HUMAN 
Synonyms NFBD1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Co-localization [19]
3 Co-localization [20]
Interacting Protein Name PAX-interacting protein 1 (PAXIP1) Interacting Protein Interacting Protein Info
UniProt ID
PAXI1_HUMAN 
Synonyms CAGF29; PACIP1; PAXIP1L; PTIP; TNRC2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Co-fractionation [22]
References  Top
REF 1 Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damage. Nucleic Acids Res. 2015 Jul 13;43(12):5936-47.
REF 2 Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks. Nature. 2009 Dec 17;462(7275):935-9.
REF 3 Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome. PLoS Genet. 2011 Apr;7(4):e1001381.
REF 4 ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007 May 25;316(5828):1160-6.
REF 5 Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol. 2004 Sep 13;166(6):801-13.
REF 6 DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol. 2002 Dec;4(12):993-7.
REF 7 MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks. Cell Cycle. 2011 Jul 1;10(13):2218-32.
REF 8 The proximity ligation assay reveals that at DNA double-strand breaks WRAP53 associates with H2AX and controls interactions between RNF8 and MDC1. Nucleus. 2015;6(5):417-24.
REF 9 Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. J Biol Chem. 2003 May 30;278(22):19579-82.
REF 10 Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell. 2006 Dec 29;127(7):1361-73.
REF 11 The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation. Mol Cell. 2016 May 5;62(3):409-421.
REF 12 A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint. PLoS Biol. 2010 Jan 26;8(1):e1000287.
REF 13 A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell. 2006 Aug 11;126(3):529-42.
REF 14 53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms. Mol Cell. 2016 Oct 6;64(1):51-64.
REF 15 The 8-kDa dynein light chain binds to p53-binding protein 1 and mediates DNA damage-induced p53 nuclear accumulation. J Biol Chem. 2005 Mar 4;280(9):8172-9.
REF 16 An acetyl-methyl switch drives a conformational change in p53. Structure. 2015 Feb 3;23(2):322-31.
REF 17 Two cellular proteins that bind to wild-type but not mutant p53. Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):6098-102.
REF 18 The direct interaction between 53BP1 and MDC1 is required for the recruitment of 53BP1 to sites of damage. J Biol Chem. 2009 Jan 2;284(1):426-35.
REF 19 MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. J Biol Chem. 2007 Nov 30;282(48):35416-23.
REF 20 MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature. 2003 Feb 27;421(6926):961-6.
REF 21 Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. J Biol Chem. 2004 Dec 31;279(53):55562-9.
REF 22 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.

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