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| Target General Information |
Top |
| Target ID |
T35486 |
Target Info
|
| Target Name |
GTPase NRas (NRAS) |
| Synonyms |
Transforming protein N-Ras; HRAS1 |
| Target Type |
Clinical trial Target |
| Gene Name |
NRAS |
| Biochemical Class |
Small GTPase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Kinases |
[+] 1 Kinases |
+ |
| Interacting Target Name |
Serine/threonine-protein kinase B-raf (BRAF) |
Successful Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
V-Raf murine sarcoma viral oncogene homolog B1; Serine/threonine-protein kinase B-raf; RAFB1; Proto-oncogene B-Raf; P94; BRAF1; BRAF(V599E); BRAF serine/threonine kinase; B-raf protein; B-Raf |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Yeast two hybrid |
[2] |
| References |
Top |
| REF 1 |
Inhibition of Ras/Raf interaction by anti-oncogenic mutants of neurofibromin, the neurofibromatosis type 1 (NF1) gene product, in cell-free systems. J Biol Chem. 1995 Dec 1;270(48):28834-8.
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| REF 2 |
Discrimination of amino acids mediating Ras binding from noninteracting residues affecting raf activation by double mutant analysis. J Biol Chem. 1997 Nov 21;272(47):29927-33.
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