Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T44068 Target Info
Target Name Adrenergic receptor beta-1 (ADRB1)
Synonyms Beta-1 adrenoreceptor; Beta-1 adrenoceptor; Beta-1 adrenergic receptor; B1AR; ADRB1R
Target Type Successful Target
Gene Name ADRB1
Biochemical Class GPCR rhodopsin
UniProt ID
ADRB1_HUMAN 
Target Interacting Proteins  Top
Microtubule-associated [+] 1 Microtubule-associated +
Interacting Target Name Presynaptic density protein 95 (DLG4) Clinical trial Target Interacting Protein Info
UniProt ID
DLG4_HUMAN 
Synonyms Synapse-associated protein 90; SAP-90; SAP90; PSD-95; PSD95; Postsynaptic density-95; Postsynaptic density protein 95; Disks large homolog 4; Discs, large homolog 4
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [1]
3 Yeast two hybrid [1]
Other proteins [+] 1 Other proteins +
Interacting Target Name Beta-arrestin-1 (ARRB1) Literature-reported Target Interacting Protein Info
UniProt ID
ARRB1_HUMAN 
Synonyms Non-visual arrestin-2; Betaarrestin1; Arrestin beta-1; Arrestin beta1; ARR1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Reconstituted Complex [3]
References  Top
REF 1 beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors. J Biol Chem. 2000 Dec 8;275(49):38659-66.
REF 2 Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation. Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14555-60.
REF 3 Interaction with beta-arrestin determines the difference in internalization behavor between beta1- and beta2-adrenergic receptors. J Biol Chem. 2000 Sep 15;275(37):29082-90.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.