Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T46849 Target Info
Target Name DNA mismatch repair protein MSH2 (MSH2)
Synonyms hMSH2; MutS protein homolog 2; Mismatch repair gene Msh2
Target Type Literature-reported Target
Gene Name MSH2
UniProt ID
MSH2_HUMAN 
Target Interacting Proteins  Top
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 6 (HDAC6) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC6_HUMAN 
Synonyms KIAA0901; JM21; HD6
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Biochemical Activity [2]
4 Co-fractionation [2]
Ester hydrolases [+] 4 Ester hydrolases +
Interacting Protein Name DNA mismatch repair protein Msh6 (MSH6) Interacting Protein Interacting Protein Info
UniProt ID
MSH6_HUMAN 
Synonyms GTBP; GTMBP; HNPCC5; HSAP; p160
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [4]
3 Co-fractionation [5]
4 Co-fractionation [6]
5 Co-localization [7]
6 Co-purification [8]
7 Reconstituted Complex [9]
8 Reconstituted Complex [10]
9 Reconstituted Complex [11]
10 Reconstituted Complex [12]
11 Reconstituted Complex [13]
Interacting Protein Name DNA mismatch repair protein Msh3 (MSH3) Interacting Protein Interacting Protein Info
UniProt ID
MSH3_HUMAN 
Synonyms DUP; MRP1
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [14]
3 Co-fractionation [6]
4 Reconstituted Complex [9]
5 Reconstituted Complex [10]
6 Reconstituted Complex [11]
7 Reconstituted Complex [12]
Interacting Protein Name Exonuclease 1 (EXO1) Interacting Protein Interacting Protein Info
UniProt ID
EXO1_HUMAN 
Synonyms HEX1; hExoI
Evidence Score (E-score) 4 Experimental Evidences +
1 Reconstituted Complex [15]
2 Reconstituted Complex [16]
3 Reconstituted Complex [17]
4 Yeast two hybrid [18]
Interacting Target Name DNA mismatch repair protein Mlh1 (MLH1) Literature-reported Target Interacting Protein Info
UniProt ID
MLH1_HUMAN 
Synonyms MutL protein homolog 1; COCA2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Co-localization [7]
3 Co-purification [8]
Kinases [+] 2 Kinases +
Interacting Target Name Serine/threonine-protein kinase ATR (FRP1) Clinical trial Target Interacting Protein Info
UniProt ID
ATR_HUMAN 
Synonyms FRAP-related protein 1; Ataxia telangiectasia and Rad3-related protein
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [3]
3 Co-localization [20]
4 Reconstituted Complex [3]
Interacting Target Name Cyclin-dependent kinase 9 (CDK9) Clinical trial Target Interacting Protein Info
UniProt ID
CDK9_HUMAN 
Synonyms Tat-associated kinase complex catalytic subunit; TAK; Similar to cyclin-dependent kinase 9; Serine/threonine-protein kinase PITALRE; Cyclin-dependent protein kinase Cdk9; Cell division protein kinase 9; Cell division cycle 2-like protein kinase 4; CDC2-related kinase; CDC2L4; C-2K
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [21]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor beta (ESR2) Successful Target Interacting Protein Info
UniProt ID
ESR2_HUMAN 
Synonyms Oestrogen receptor beta; Nuclear receptor subfamily 3 group A member 2; NR3A2; ESTRB; ER-beta; Erbeta; Beta-1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [22]
2 Affinity Capture-Western [23]
3 Reconstituted Complex [23]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name Proto-oncogene c-Myc (MYC) Literature-reported Target Interacting Protein Info
UniProt ID
MYC_HUMAN 
Synonyms Transcription factor p64; Proto-oncogene c-Myc; Myc proto-oncogene protein; C-myc oncogene; C-myc; Class E basic helix-loop-helix protein 39; bHLHe39
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [24]
2 Affinity Capture-Western [25]
References  Top
REF 1 A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors. Cell Death Differ. 2013 Oct;20(10):1306-16.
REF 2 HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutS. Mol Cell. 2014 Jul 3;55(1):31-46.
REF 3 MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15387-92.
REF 4 Identification of mismatch repair protein complexes in HeLa nuclear extracts and their interaction with heteroduplex DNA. J Biol Chem. 2000 Jun 9;275(23):17808-13.
REF 5 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 6 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 7 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 8 BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev. 2000 Apr 15;14(8):927-39.
REF 9 Interactions of human hMSH2 with hMSH3 and hMSH2 with hMSH6: examination of mutations found in hereditary nonpolyposis colorectal cancer. Mol Cell Biol. 1998 Nov;18(11):6616-23.
REF 10 hMSH5: a human MutS homologue that forms a novel heterodimer with hMSH4 and is expressed during spermatogenesis. Cancer Res. 1999 Feb 15;59(4):816-22.
REF 11 hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13629-34.
REF 12 The nucleotide binding dynamics of human MSH2-MSH3 are lesion dependent. Nat Struct Mol Biol. 2009 May;16(5):550-7.
REF 13 The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch. Cell. 1997 Dec 26;91(7):995-1005.
REF 14 hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA. Curr Biol. 1996 Sep 1;6(9):1181-4.
REF 15 Human exonuclease I interacts with the mismatch repair protein hMSH2. Cancer Res. 1998 Oct 15;58(20):4537-42.
REF 16 Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair. Mol Cell Biol. 2009 Feb;29(3):907-18.
REF 17 14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif. DNA Repair (Amst). 2012 Mar 1;11(3):267-77.
REF 18 Identification of factors interacting with hMSH2 in the fetal liver utilizing the yeast two-hybrid system. In vivo interaction through the C-terminal domains of hEXO1 and hMSH2 and comparative expression analysis. Mutat Res. 2000 Jun 30;460(1):41-52.
REF 19 N-terminus of hMLH1 confers interaction of hMutLalpha and hMutLbeta with hMutSalpha. Nucleic Acids Res. 2003 Jun 15;31(12):3217-26.
REF 20 hMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis. J Biol Chem. 2011 Mar 25;286(12):10411-8.
REF 21 Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in -Catenin-Active Cancers. Cell Syst. 2016 Sep 28;3(3):302-316.e4.
REF 22 Quantitative mapping of RNA-mediated nuclear estrogen receptor interactome in human breast cancer cells. Sci Data. 2018 Mar 6;5:180031.
REF 23 The DNA mismatch repair gene hMSH2 is a potent coactivator of oestrogen receptor alpha. Br J Cancer. 2005 Jun 20;92(12):2286-91.
REF 24 Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. Cell Cycle. 2007 Jan 15;6(2):205-17.
REF 25 Interactions of the DNA mismatch repair proteins MLH1 and MSH2 with c-MYC and MAX. Oncogene. 2003 Feb 13;22(6):819-25.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.