Target Interacting Protein Information
Target General Information | Top | ||||
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Target ID | T50942 | Target Info | |||
Target Name | Low-affinity nerve growth factor receptor (NGFR) | ||||
Synonyms | p75 ICD; Tumor necrosis factor receptor superfamily member 16; TNFRSF16; P75neurotrophin receptor (p75(NTR)); P75NTR; P75ICD; NGFreceptor; NGF-P75 receptor; NGF receptor; Lowaffinity neurotrophin receptor p75NTR; Low affinity neurotrophin receptor p75NTR; Gp80-LNGFR; CD271; 75kD-neurotrophin receptor | ||||
Target Type | Successful Target | ||||
Gene Name | NGFR | ||||
Biochemical Class | Cytokine receptor | ||||
UniProt ID |
Target Interacting Proteins | Top | ||||
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Acyltransferases | [+] 1 Acyltransferases | + | |||
Interacting Target Name | TNF receptor-associated factor 6 (TRAF6) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | RNF85; RING-type E3 ubiquitin transferase TRAF6; RING finger protein 85; Interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [1] | |||
2 | Affinity Capture-Western | [2] | |||
3 | Affinity Capture-Western | [3] | |||
4 | Reconstituted Complex | [2] | |||
Adapter proteins | [+] 2 Adapter proteins | + | |||
Interacting Protein Name | Protein BEX3 (BEX3) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | BEX3; Bex; DXS6984E; HGR74; NADE | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [4] | |||
2 | Affinity Capture-Western | [5] | |||
3 | Reconstituted Complex | [4] | |||
Interacting Protein Name | TNF receptor-associated factor 4 (TRAF4) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CART1; MLN62; RNF83 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [1] | |||
2 | Reconstituted Complex | [1] | |||
3 | Reconstituted Complex | [6] | |||
Other proteins | [+] 1 Other proteins | + | |||
Interacting Protein Name | Necdin (NDN) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | HsT16328; PWCR | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [7] | |||
2 | Affinity Capture-Western | [8] | |||
3 | Reconstituted Complex | [9] |
References | Top | ||||
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REF 1 | TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. J Biol Chem. 1999 Oct 15;274(42):30202-8. | ||||
REF 2 | A functional interaction between the p75 neurotrophin receptor interacting factors, TRAF6 and NRIF. J Biol Chem. 2004 Apr 16;279(16):16646-56. | ||||
REF 3 | TRAF6 and p62 inhibit amyloid -induced neuronal death through p75 neurotrophin receptor. Neurochem Int. 2012 Dec;61(8):1289-93. | ||||
REF 4 | NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR. J Biol Chem. 2000 Jun 9;275(23):17566-70. | ||||
REF 5 | The TSC1 gene product hamartin interacts with NADE. Mol Cell Neurosci. 2007 May;35(1):100-8. | ||||
REF 6 | TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues. Am J Pathol. 1998 Jun;152(6):1549-61. | ||||
REF 7 | Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome. J Neurosci. 2003 Apr 15;23(8):3209-20. | ||||
REF 8 | The p75 neurotrophin receptor interacts with multiple MAGE proteins. J Biol Chem. 2002 Dec 20;277(51):49101-4. | ||||
REF 9 | Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor. J Biol Chem. 2004 Jan 16;279(3):1703-12. |
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