Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T53904 Target Info
Target Name HIF-prolyl hydroxylase 1 (HPH-1)
Synonyms Prolyl hydroxylase domain-containing protein 1; PHD1; Hypoxia-inducible factor prolyl hydroxylase 1; HPH-3; HIF-PH1; HIF-PH; Estrogen-induced tag6; Estrogen-induced tag 6; Egl nine homolog 2; EIT6; EIT-6
Target Type Successful Target
Gene Name EGLN2
Biochemical Class Paired donor oxygen oxidoreductase
UniProt ID
EGLN2_HUMAN 
Target Interacting Proteins  Top
Transcription regulators [+] 2 Transcription regulators +
Interacting Target Name Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Interacting Protein Info
UniProt ID
HIF1A_HUMAN 
Synonyms Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Interacting Target Name Hypoxia-inducible factor 2 alpha (HIF-2A) Successful Target Interacting Protein Info
UniProt ID
EPAS1_HUMAN 
Synonyms PASD2; PAS domain-containing protein 2; MOP2; Member of PAS protein 2; Hypoxia-inducible factor 2-alpha; HLF; HIF-2-alpha; HIF2-alpha; HIF2A; HIF-1-alpha-like factor; EPAS-1; Endothelial PAS domain-containing protein 1; Class E basic helix-loop-helix protein 73; bHLHe73; Basic-helix-loop-helix-PAS protein MOP2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Reconstituted Complex [2]
References  Top
REF 1 CDK-dependent phosphorylation of PHD1 on serine 130 alters its substrate preference in cells. J Cell Sci. 2016 Jan 1;129(1):191-205.
REF 2 The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability. Mol Cell Biol. 2007 May;27(10):3758-68.
REF 3 Identification of the hypoxia-inducible factor 2 nuclear interactome in melanoma cells reveals master proteins involved in melanoma development. Mol Cell Proteomics. 2013 Mar;12(3):736-48.

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