Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T56545 Target Info
Target Name Apolipoprotein A-I (APOA1)
Synonyms Truncated apolipoprotein AI; Apolipoprotein A1; ApoAI; ApoA-I; Apo-AI
Target Type Clinical trial Target
Gene Name APOA1
Biochemical Class Apolipoprotein
UniProt ID
APOA1_HUMAN 
Target Interacting Proteins  Top
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name Lecithin-cholesterol acyltransferase (LCAT) Clinical trial Target Interacting Protein Info
UniProt ID
LCAT_HUMAN 
Synonyms Phospholipidcholesterolacyltransferase; Phospholipid-cholesterol acyltransferase; Phosphatidylcholine-sterol acyltransferase; Phosphatidylcholinesterol acyltransferase
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [1]
2 Co-purification [2]
3 Reconstituted Complex [3]
Hydrolysis-driven transporters [+] 1 Hydrolysis-driven transporters +
Interacting Target Name ATP-binding cassette transporter A1 (ABCA1) Successful Target Interacting Protein Info
UniProt ID
ABCA1_HUMAN 
Synonyms Cholesterol mobilizing transporter ABCA1; Cholesterol efflux regulatory protein; CERP; ATP-binding cassette transporter A1; ATP-binding cassette transporter (ABCA1) transmembrane protein; ATP-binding cassette sub-family A member 1; ATP-binding cassette 1; ABC-1; ABC1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Reconstituted Complex [5]
Other proteins [+] 3 Other proteins +
Interacting Target Name Apolipoprotein A-II (APOA2) Literature-reported Target Interacting Protein Info
UniProt ID
APOA2_HUMAN 
Synonyms Apolipoprotein A2; Apo-AII; ApoA-II
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-purification [2]
2 Reconstituted Complex [6]
Interacting Protein Name Apolipoprotein C-I (APOC1) Interacting Protein Interacting Protein Info
UniProt ID
APOC1_HUMAN 
Synonyms Apo.CI; ApoC.I
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Yeast two hybrid [8]
Interacting Protein Name Fibrinogen alpha chain (FGA) Interacting Protein Interacting Protein Info
UniProt ID
FIBA_HUMAN 
Synonyms Fib2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Co-localization [9]
References  Top
REF 1 A protein cofactor of lecithin:cholesterol acyltransferase. Biochem Biophys Res Commun. 1972 Feb 25;46(4):1493-8.
REF 2 Distribution and localization of lecithin:cholesterol acyltransferase and cholesteryl ester transfer activity in A-I-containing lipoproteins. J Lipid Res. 1986 Nov;27(11):1135-44.
REF 3 Site-directed mutagenesis and structure-function analysis of the human apolipoprotein A-I. Relation between lecithin-cholesterol acyltransferase activation and lipid binding. J Biol Chem. 1992 Aug 15;267(23):16553-60.
REF 4 Apolipoprotein A-1 binding protein promotes macrophage cholesterol efflux by facilitating apolipoprotein A-1 binding to ABCA1 and preventing ABCA1 ... Atherosclerosis. 2016 May;248:149-59.
REF 5 Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I. J Biol Chem. 2002 Sep 6;277(36):33178-87.
REF 6 Formation of spherical, reconstituted high density lipoproteins containing both apolipoproteins A-I and A-II is mediated by lecithin:cholesterol acyltransferase. J Biol Chem. 2000 Mar 24;275(12):9019-25.
REF 7 An investigation into the human serum "interactome". Electrophoresis. 2004 May;25(9):1289-98.
REF 8 Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I. Genomics. 2002 May;79(5):693-702.
REF 9 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.

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