Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T65879 Target Info
Target Name Inhibitor of nuclear factor kappa-B kinase alpha (IKKA)
Synonyms Transcription factor 16; TCF16; TCF-16; Nuclear factor NFkappaB inhibitor kinase alpha; Nuclear factor NF-kappa-B inhibitor kinase alpha; NFKBIKA; Inhibitory kappa B kinasea; Inhibitor of nuclear factor kappa-B kinase subunit alpha; IkappaB kinase A; IkBKA; IKK1; IKK-alpha; IKK-A; I-kappa-B kinase alpha; I-kappa-B kinase 1; I kappa-B kinase alpha; Conserved helix-loop-helix ubiquitous kinase
Target Type Literature-reported Target
Gene Name CHUK
Biochemical Class Kinase
UniProt ID
IKKA_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Nuclear receptor coactivator 3 (NCOA3) Literature-reported Target Interacting Protein Info
UniProt ID
NCOA3_HUMAN 
Synonyms TRAM-1; TRAM1; Thyroid hormone receptor activator molecule 1; Steroid receptor coactivator protein 3; SRC-3; Receptor-associated coactivator 3; RAC-3; RAC3; PCIP; NCoA-3; Class E basic helix-loop-helix protein 42; CBP-interacting protein; bHLHe42; Amplified in breast cancer-1 protein; Amplified in breast cancer 1 protein; AIB1 (SRC-3); AIB-1; AIB1; ACTR
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Biochemical Activity [3]
4 Co-localization [4]
5 Reconstituted Complex [2]
Cell division cycle proteins [+] 1 Cell division cycle proteins +
Interacting Target Name Hsp90 co-chaperone Cdc37 (CDC37) Literature-reported Target Interacting Protein Info
UniProt ID
CDC37_HUMAN 
Synonyms p50Cdc37; Hsp90 co-chaperone Cdc37, N-terminally processed; Hsp90 chaperone protein kinase-targeting subunit; CDC37A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Reconstituted Complex [6]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [8]
Kinases [+] 4 Kinases +
Interacting Target Name Inhibitor of nuclear factor kappa-B kinase beta (IKKB) Clinical trial Target Interacting Protein Info
UniProt ID
IKKB_HUMAN 
Synonyms Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Inhibitory kappa B kinase b; Inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-beta; IKKbeta; IKK-B; IKK-2; IKK2; IkBKB; I-kappa-B-kinase beta; IkappaB kinase beta; I-kappa-B kinase 2; IkappaB kinase 2
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [9]
3 Biochemical Activity [10]
4 Co-fractionation [11]
5 Co-localization [12]
6 Co-purification [13]
7 Reconstituted Complex [9]
Interacting Target Name Serine/threonine-protein kinase NIK (MAP3K14) Literature-reported Target Interacting Protein Info
UniProt ID
M3K14_HUMAN 
Synonyms NIK; NF-kappa-beta-inducing kinase; Mitogen-activated protein kinase kinase kinase 14; HsNIK
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [14]
2 Affinity Capture-Western [15]
3 Biochemical Activity [16]
4 Co-localization [12]
5 Reconstituted Complex [17]
6 Yeast two hybrid [18]
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Biochemical Activity [19]
3 Co-localization [12]
Interacting Target Name TGF-beta-activated kinase 1 (MAP3K7) Literature-reported Target Interacting Protein Info
UniProt ID
M3K7_HUMAN 
Synonyms Transforming growth factor-beta-activated kinase 1; TAK1; Mitogen-activated protein kinase kinase kinase 7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Co-localization [12]
Peptidases [+] 1 Peptidases +
Interacting Target Name JUN activation domain binding protein (COPS5) Literature-reported Target Interacting Protein Info
UniProt ID
CSN5_HUMAN 
Synonyms Signalosome subunit 5; SGN5; Jun activation domain-binding protein 1; JAB1; CSN5; COP9 signalosome complex subunit 5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Biochemical Activity [22]
Transcription regulators [+] 2 Transcription regulators +
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [23]
2 Biochemical Activity [24]
3 Yeast two hybrid [23]
Interacting Protein Name Transcription factor p65 (RELA) Interacting Protein Interacting Protein Info
UniProt ID
TF65_HUMAN 
Synonyms NFKB3; p65
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Biochemical Activity [25]
Other proteins [+] 6 Other proteins +
Interacting Protein Name NF-kappa-B essential modulator (IKBKG) Interacting Protein Interacting Protein Info
UniProt ID
NEMO_HUMAN 
Synonyms AMCBX1; FIP.3; FIP3; Fip3p; IKK.gamma; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [26]
3 Biochemical Activity [27]
4 Co-fractionation [11]
5 Co-purification [28]
6 Reconstituted Complex [29]
Interacting Target Name Beta-arrestin-2 (ARRB2) Literature-reported Target Interacting Protein Info
UniProt ID
ARRB2_HUMAN 
Synonyms Non-visual arrestin-3; Betaarrestin2; Arrestin beta-2; Arrestin beta2; ARR2; ARB2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [30]
2 Co-localization [12]
Interacting Protein Name B-cell lymphoma/leukemia 10 (BCL10) Interacting Protein Interacting Protein Info
UniProt ID
BCL10_HUMAN 
Synonyms CARMEN; CIPER; CLAP; IMD37; c.E10; mE10
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [31]
2 Biochemical Activity [32]
Interacting Protein Name NF-kappa-B inhibitor alpha (NFKBIA) Interacting Protein Interacting Protein Info
UniProt ID
IKBA_HUMAN 
Synonyms IKBA; MAD.3; NFKBI
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [33]
2 Biochemical Activity [34]
Interacting Protein Name NF-kappa-B inhibitor beta (NFKBIB) Interacting Protein Interacting Protein Info
UniProt ID
IKBB_HUMAN 
Synonyms IKBB; TRIP9
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [35]
2 Biochemical Activity [36]
Interacting Target Name Tumor necrosis factor (TNF) Successful Target Interacting Protein Info
UniProt ID
TNFA_HUMAN 
Synonyms Tumour necrosis factor alpha; Tumour necrosis factor; Tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor; TNFSF2; TNF-alpha; TNFalpha; TNF-a; TNFA; TNF alpha; Cachectin
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [37]
References  Top
REF 1 Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes. Mol Endocrinol. 2005 Oct;19(10):2451-65.
REF 2 Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase. Mol Cell Biol. 2002 May;22(10):3549-61.
REF 3 Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways. Mol Cell. 2004 Sep 24;15(6):937-49.
REF 4 Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation. Mol Cell. 2005 Apr 1;18(1):71-82.
REF 5 Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Immunity. 2011 Sep 23;35(3):426-40.
REF 6 TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. Mol Cell. 2002 Feb;9(2):401-10.
REF 7 A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. Mol Cell Proteomics. 2010 Feb;9(2):255-70.
REF 8 Arsenic trioxide exerts antimyeloma effects by inhibiting activity in the cytoplasmic substrates of histone deacetylase 6. PLoS One. 2012;7(2):e32215.
REF 9 Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex. Science. 2000 Sep 1;289(5484):1550-4.
REF 10 A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity. J Biol Chem. 2011 Sep 16;286(37):32277-88.
REF 11 Role of IKKgamma/nemo in assembly of the Ikappa B kinase complex. J Biol Chem. 2001 Feb 9;276(6):4494-500.
REF 12 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 13 Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate. Science. 1998 Aug 28;281(5381):1360-3.
REF 14 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 15 Allosteric regulation of the ubiquitin:NIK and ubiquitin:TRAF3 E3 ligases by the lymphotoxin-beta receptor. J Biol Chem. 2010 May 28;285(22):17148-55.
REF 16 The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature. 1999 Mar 18;398(6724):252-6.
REF 17 Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40. J Biol Chem. 2001 May 4;276(18):14602-6.
REF 18 Identification and characterization of an IkappaB kinase. Cell. 1997 Jul 25;90(2):373-83.
REF 19 NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature. 1999 Sep 2;401(6748):82-5.
REF 20 Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation. J Biol Chem. 1999 Apr 9;274(15):10641-8.
REF 21 Endothelial CSN5 impairs NF-B activation and monocyte adhesion to endothelial cells and is highly expressed in human atherosclerotic lesions. Thromb Haemost. 2013 Jul;110(1):141-52.
REF 22 Crosstalk between the NF-kappaB activating IKK-complex and the CSN signalosome. J Cell Mol Med. 2010 Jun;14(6B):1555-68.
REF 23 Nuclear role of I kappa B Kinase-gamma/NF-kappa B essential modulator (IKK gamma/NEMO) in NF-kappa B-dependent gene expression. J Biol Chem. 2004 Jan 30;279(5):3509-15.
REF 24 Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB. Mol Cell. 2007 Apr 13;26(1):75-87.
REF 25 IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300. Mol Cell Biol. 2006 Jan;26(2):457-71.
REF 26 IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Nature. 1998 Sep 17;395(6699):297-300.
REF 27 Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli. Science. 2006 Feb 24;311(5764):1141-6.
REF 28 Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell. 2000 Oct 13;103(2):351-61.
REF 29 Dimerization of the I kappa B kinase-binding domain of NEMO is required for tumor necrosis factor alpha-induced NF-kappa B activity. Mol Cell Biol. 2006 Dec;26(24):9209-19.
REF 30 Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12011-6.
REF 31 vCLAP, a caspase-recruitment domain-containing protein of equine Herpesvirus-2, persistently activates the Ikappa B kinases through oligomerization of IKKgamma. J Biol Chem. 2001 Feb 2;276(5):3183-7.
REF 32 IB kinase phosphorylation of TRAF4 downregulates innate immune signaling. Mol Cell Biol. 2012 Jul;32(13):2479-89.
REF 33 Tautomycetin suppresses the TNFalpha/NF-kappaB pathway via inhibition of IKK activation. Int J Oncol. 2008 Nov;33(5):1027-35.
REF 34 A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature. 1997 Aug 7;388(6642):548-54.
REF 35 Disruption of NF-kappa B signaling and chemokine gene activation by retroviral mediated expression of IKK gamma/NEMO mutants. Virology. 2001 Aug 1;286(2):422-33.
REF 36 IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science. 1997 Oct 31;278(5339):866-9.
REF 37 Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Mol Cell. 2009 Dec 11;36(5):831-44.

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