Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Tumor necrosis factor (TNF) | Successful | Target Info | ||
| UniProt ID | TNFA_HUMAN | ||||
| Gene Name | TNF | ||||
| Gene ID | 7124 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Clinical trial Target(s) | Inhibitor of nuclear factor kappa-B kinase beta (IKKB) | Target Info | PPI Info | [1] | |
| Cellular inhibitor of apoptosis 1 (BIRC2) | Target Info | PPI Info | [1] | ||
| Tumor necrosis factor receptor type I (TNF-R1) | Target Info | PPI Info | [2] | ||
| Receptor-interacting protein 1 (RIPK1) | Target Info | PPI Info | [1] | ||
| Interacting Patented-recorded Target(s) | NF-kappa-B-activating kinase (TBK1) | Target Info | PPI Info | [3] | |
| Polyubiquitin-C (UBC) | Target Info | PPI Info | [1] | ||
| Interacting Literature-reported Target(s) | Inhibitor of nuclear factor kappa-B kinase alpha (IKKA) | Target Info | PPI Info | [1] | |
| TGF-beta-activated kinase 1 (MAP3K7) | Target Info | PPI Info | [4] | ||
| Linear ubiquitin chain assembly complex (RBCK1) | Target Info | PPI Info | [1] | ||
| Zinc finger protein A20 (TNFAIP3) | Target Info | PPI Info | [4] | ||
| Tumor necrosis factor receptor type II (TNF-R2) | Target Info | PPI Info | [5] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Mol Cell. 2009 Dec 11;36(5):831-44. | ||||
| REF 2 | Identification of a 60-kD tumor necrosis factor (TNF) receptor as the major signal transducing component in TNF responses. J Exp Med. 1990 Oct 1;172(4):1019-23. | ||||
| REF 3 | NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-inter... J Biol Chem. 2004 Dec 17;279(51):53266-71. | ||||
| REF 4 | SPATA2 links CYLD to the TNF- receptor signaling complex and modulates the receptor signaling outcomes. EMBO J. 2016 Sep 1;35(17):1868-84. | ||||
| REF 5 | Synergistic differentiation-promoting activity of interferon gamma and tumor necrosis factor-alpha: role of receptor regulation on human neuroblasts. J Natl Cancer Inst. 1994 Nov 16;86(22):1694-701. | ||||
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