Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T81358 Target Info
Target Name CDC7-related kinase (CDC7)
Synonyms huCdc7; HsCdc7; Cell division cycle 7related protein kinase; Cell division cycle 7-related protein kinase; CDC7related kinase; CDC7L1
Target Type Clinical trial Target
Gene Name CDC7
Biochemical Class Kinase
UniProt ID
CDC7_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 4 Acid anhydride hydrolases +
Interacting Protein Name DNA replication licensing factor MCM2 (MCM2) Interacting Protein Interacting Protein Info
UniProt ID
MCM2_HUMAN 
Synonyms BM28; CCNL1; CDCL1; D3S3194; MITOTIN; cdc19
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [2]
3 Biochemical Activity [3]
4 Biochemical Activity [4]
5 Biochemical Activity [5]
6 Yeast two hybrid [6]
Interacting Target Name DNA replication licensing factor MCM7 (MCM7) Literature-reported Target Interacting Protein Info
UniProt ID
MCM7_HUMAN 
Synonyms P1.1-MCM3; Minichromosome maintenanceprotein 7; MCM2; CDC47 homolog; CDC47
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [3]
2 Yeast two hybrid [6]
Interacting Protein Name DNA replication licensing factor MCM3 (MCM3) Interacting Protein Interacting Protein Info
UniProt ID
MCM3_HUMAN 
Synonyms HCC5; P1.MCM3; P1.h; RLFB
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [7]
2 Reconstituted Complex [8]
Interacting Protein Name DNA replication licensing factor MCM4 (MCM4) Interacting Protein Interacting Protein Info
UniProt ID
MCM4_HUMAN 
Synonyms CDC21; CDC54; NKCD; NKGCD; P1.CDC21; hCdc21
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [3]
2 Yeast two hybrid [6]
Kinases [+] 1 Kinases +
Interacting Target Name Cyclin-dependent kinase 2 (CDK2) Clinical trial Target Interacting Protein Info
UniProt ID
CDK2_HUMAN 
Synonyms SIN3-associated protein; Sin3 associated polypeptide; P33 protein kinase; Cell division protein kinase 2; CDKN2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [1]
Other proteins [+] 2 Other proteins +
Interacting Protein Name Protein DBF4 homolog A (DBF4) Interacting Protein Interacting Protein Info
UniProt ID
DBF4A_HUMAN 
Synonyms ASK; CHIF; DBF4A; ZDBF1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Affinity Capture-Western [10]
3 Biochemical Activity [3]
4 Reconstituted Complex [9]
5 Yeast two hybrid [6]
6 Yeast two hybrid [10]
Interacting Protein Name Origin recognition complex subunit 6 (ORC6) Interacting Protein Interacting Protein Info
UniProt ID
ORC6_HUMAN 
Synonyms ORC6L
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [8]
2 Yeast two hybrid [6]
References  Top
REF 1 The replicon initiation burst released by reoxygenation of hypoxic T24 cells is accompanied by changes of MCM2 and Cdc7. J Biochem Mol Biol. 2007 Sep 30;40(5):805-13.
REF 2 The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin assembly factor 1 with proliferating cell nuclear antigen. EMBO Rep. 2006 Aug;7(8):817-23.
REF 3 Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks. J Biol Chem. 2000 Sep 15;275(37):29042-52.
REF 4 Identification of Mcm2 phosphorylation sites by S-phase-regulating kinases. J Biol Chem. 2006 Apr 14;281(15):10281-90.
REF 5 Inhibition of DNA damage-induced apoptosis through Cdc7-mediated stabilization of Tob. J Biol Chem. 2012 Nov 23;287(48):40256-65.
REF 6 Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. J Mol Biol. 2003 Mar 14;327(1):111-28.
REF 7 Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7. EMBO J. 1997 Jul 16;16(14):4340-51.
REF 8 Self-assembling protein microarrays. Science. 2004 Jul 2;305(5680):86-90.
REF 9 Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication. EMBO J. 1999 Oct 15;18(20):5703-13.
REF 10 A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells. Mol Cell Biol. 1999 Jul;19(7):5083-95.

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