Target Interacting Protein Information
Target General Information | Top | ||||
---|---|---|---|---|---|
Target ID | T81358 | Target Info | |||
Target Name | CDC7-related kinase (CDC7) | ||||
Synonyms | huCdc7; HsCdc7; Cell division cycle 7related protein kinase; Cell division cycle 7-related protein kinase; CDC7related kinase; CDC7L1 | ||||
Target Type | Clinical trial Target | ||||
Gene Name | CDC7 | ||||
Biochemical Class | Kinase | ||||
UniProt ID |
Target Interacting Proteins | Top | ||||
---|---|---|---|---|---|
Acid anhydride hydrolases | [+] 4 Acid anhydride hydrolases | + | |||
Interacting Protein Name | DNA replication licensing factor MCM2 (MCM2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | BM28; CCNL1; CDCL1; D3S3194; MITOTIN; cdc19 | ||||
Evidence Score (E-score) | 6 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [1] | |||
2 | Biochemical Activity | [2] | |||
3 | Biochemical Activity | [3] | |||
4 | Biochemical Activity | [4] | |||
5 | Biochemical Activity | [5] | |||
6 | Yeast two hybrid | [6] | |||
Interacting Target Name | DNA replication licensing factor MCM7 (MCM7) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | P1.1-MCM3; Minichromosome maintenanceprotein 7; MCM2; CDC47 homolog; CDC47 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Biochemical Activity | [3] | |||
2 | Yeast two hybrid | [6] | |||
Interacting Protein Name | DNA replication licensing factor MCM3 (MCM3) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | HCC5; P1.MCM3; P1.h; RLFB | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Biochemical Activity | [7] | |||
2 | Reconstituted Complex | [8] | |||
Interacting Protein Name | DNA replication licensing factor MCM4 (MCM4) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CDC21; CDC54; NKCD; NKGCD; P1.CDC21; hCdc21 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Biochemical Activity | [3] | |||
2 | Yeast two hybrid | [6] | |||
Kinases | [+] 1 Kinases | + | |||
Interacting Target Name | Cyclin-dependent kinase 2 (CDK2) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | SIN3-associated protein; Sin3 associated polypeptide; P33 protein kinase; Cell division protein kinase 2; CDKN2 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [1] | |||
2 | Biochemical Activity | [1] | |||
Other proteins | [+] 2 Other proteins | + | |||
Interacting Protein Name | Protein DBF4 homolog A (DBF4) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | ASK; CHIF; DBF4A; ZDBF1 | ||||
Evidence Score (E-score) | 6 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [9] | |||
2 | Affinity Capture-Western | [10] | |||
3 | Biochemical Activity | [3] | |||
4 | Reconstituted Complex | [9] | |||
5 | Yeast two hybrid | [6] | |||
6 | Yeast two hybrid | [10] | |||
Interacting Protein Name | Origin recognition complex subunit 6 (ORC6) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | ORC6L | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Reconstituted Complex | [8] | |||
2 | Yeast two hybrid | [6] |
References | Top | ||||
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REF 1 | The replicon initiation burst released by reoxygenation of hypoxic T24 cells is accompanied by changes of MCM2 and Cdc7. J Biochem Mol Biol. 2007 Sep 30;40(5):805-13. | ||||
REF 2 | The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin assembly factor 1 with proliferating cell nuclear antigen. EMBO Rep. 2006 Aug;7(8):817-23. | ||||
REF 3 | Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks. J Biol Chem. 2000 Sep 15;275(37):29042-52. | ||||
REF 4 | Identification of Mcm2 phosphorylation sites by S-phase-regulating kinases. J Biol Chem. 2006 Apr 14;281(15):10281-90. | ||||
REF 5 | Inhibition of DNA damage-induced apoptosis through Cdc7-mediated stabilization of Tob. J Biol Chem. 2012 Nov 23;287(48):40256-65. | ||||
REF 6 | Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. J Mol Biol. 2003 Mar 14;327(1):111-28. | ||||
REF 7 | Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7. EMBO J. 1997 Jul 16;16(14):4340-51. | ||||
REF 8 | Self-assembling protein microarrays. Science. 2004 Jul 2;305(5680):86-90. | ||||
REF 9 | Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication. EMBO J. 1999 Oct 15;18(20):5703-13. | ||||
REF 10 | A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells. Mol Cell Biol. 1999 Jul;19(7):5083-95. |
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