Protein-Protein Interaction Details
Protein General Information (TTD Target) | Top | ||||
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Full Name | DNA replication licensing factor MCM7 (MCM7) | Literature-reported | Target Info | ||
UniProt ID | MCM7_HUMAN | ||||
Gene Name | MCM7 | ||||
Gene ID | 4176 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Clinical trial Target(s) | CDC7-related kinase (CDC7) | Target Info | PPI Info | [1] | |
Hypoxia-inducible factor 1 alpha (HIF-1A) | Target Info | PPI Info | [2] | ||
Facilitates chromatin transcription complex (FACT) | Target Info | PPI Info | [3] | ||
Interacting Literature-reported Target(s) | Proto-oncogene c-Myc (MYC) | Target Info | PPI Info | [4] | |
DNA replication licensing factor MCM6 (MCM6) | Target Info | PPI Info | [5] | ||
DNA replication licensing factor MCM7 (MCM7) | Target Info | PPI Info | [6] |
References | Top | ||||
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REF 1 | Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks. J Biol Chem. 2000 Sep 15;275(37):29042-52. | ||||
REF 2 | MCM proteins are negative regulators of hypoxia-inducible factor 1. Mol Cell. 2011 Jun 10;42(5):700-12. | ||||
REF 3 | A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. Mol Cell. 2010 Nov 24;40(4):645-57. | ||||
REF 4 | Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol. 2007;3:89. | ||||
REF 5 | Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex. J Biol Chem. 2002 Nov 8;277(45):42471-9. | ||||
REF 6 | Mammalian Mcm2/4/6/7 complex forms a toroidal structure. Genes Cells. 2003 May;8(5):413-21. |
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