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| Target General Information |
Top |
| Target ID |
T83797 |
Target Info
|
| Target Name |
Hepatocyte growth factor (HGF) |
| Synonyms |
Scatter factor; SF; Hepatopoietin-A; Hepatopoeitin A; HPTA |
| Target Type |
Clinical trial Target |
| Gene Name |
HGF |
| Biochemical Class |
Peptidase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Kinases |
[+] 1 Kinases |
+ |
| Interacting Target Name |
Proto-oncogene c-Met (MET) |
Successful Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Tyrosine-protein kinase Met; SF receptor; Scatter factor receptor; Met proto-oncogene tyrosine kinase; HGF-SF receptor; HGF/SF receptor; HGF receptor; Hepatocyte growth factor receptor; C-Met receptor tyrosine kinase; C-met |
| Evidence Score (E-score) |
4 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Biochemical Activity |
[2] |
| 3 |
Fluorescence Resonance Energy Transfer |
[3] |
| 4 |
Reconstituted Complex |
[2] |
| References |
Top |
| REF 1 |
Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. EMBO J. 1991 Oct;10(10):2867-78.
|
| REF 2 |
Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells. EXS. 1993;65:131-65.
|
| REF 3 |
OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc. Oncogene. 2017 Oct 19;36(42):5852-5860.
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