Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T85544 Target Info
Target Name Target of rapamycin complex 2 MAPKAP1 (MTORC2)
Synonyms mSIN1; Target of rapamycin complex 2 subunit MAPKAP1; TORC2 subunit MAPKAP1; Stress-activated map kinase-interacting protein 1; SIN1; SAPK-interacting protein 1; Mitogen-activated protein kinase 2-associated protein 1; MIP1
Target Type Clinical trial Target
Gene Name MAPKAP1
UniProt ID
SIN1_HUMAN 
Target Interacting Proteins  Top
Kinases [+] 3 Kinases +
Interacting Target Name Serine/threonine-protein kinase mTOR (mTOR) Successful Target Interacting Protein Info
UniProt ID
MTOR_HUMAN 
Synonyms TOR kinase; Target of rapamycin; RAPT1; Rapamycin target protein 1; Rapamycin target protein; Rapamycin and FKBP12 target 1; RAFT1; Mechanistic target of rapamycin; Mammalian target of rapamycin; FRAP2; FRAP1; FRAP; FKBP-rapamycin associated protein; FKBP12-rapamycin complex-associated protein; FK506-binding protein 12-rapamycin complex-associated protein 1
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [1]
3 Affinity Capture-Western [2]
4 Affinity Capture-Western [3]
5 Affinity Capture-Western [4]
6 Affinity Capture-Western [5]
7 Affinity Capture-Western [6]
8 Affinity Capture-Western [7]
9 Co-fractionation [4]
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Biochemical Activity [2]
4 Biochemical Activity [3]
5 Reconstituted Complex [8]
6 Yeast two hybrid [8]
Interacting Target Name Protein kinase C alpha (PRKCA) Successful Target Interacting Protein Info
UniProt ID
KPCA_HUMAN 
Synonyms Protein kinase C alpha type; Protein Kinase C alpha; PRKACA; PKC-alpha; PKCalpha; PKC-A; PKCA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [8]
3 Yeast two hybrid [8]
Other proteins [+] 1 Other proteins +
Interacting Target Name MTOR complex 2 (RICTOR) Literature-reported Target Interacting Protein Info
UniProt ID
RICTR_HUMAN 
Synonyms Rapamycin-insensitive companion of mTOR; KIAA1999; hAVO3; AVO3 homolog
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [10]
3 Affinity Capture-Western [1]
4 Affinity Capture-Western [2]
5 Affinity Capture-Western [3]
6 Affinity Capture-Western [4]
7 Affinity Capture-Western [5]
8 Affinity Capture-Western [6]
9 Affinity Capture-Western [7]
10 Reconstituted Complex [11]
11 Yeast two hybrid [12]
References  Top
REF 1 SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell. 2006 Oct 6;127(1):125-37.
REF 2 The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J. 2008 Jul 23;27(14):1932-43.
REF 3 A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2. J Biol Chem. 2011 Mar 4;286(9):7182-9.
REF 4 Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev. 2006 Oct 15;20(20):2820-32.
REF 5 Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem J. 2007 Aug 1;405(3):513-22.
REF 6 mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J. 2010 Dec 1;29(23):3939-51.
REF 7 The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway. EMBO J. 2009 Dec 16;28(24):3879-92.
REF 8 Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit. Elife. 2017 Mar 7;6. pii: e19594.
REF 9 Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J. 2008 Jul 23;27(14):1919-31.
REF 10 Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Mol Cell. 2010 Sep 10;39(5):797-808.
REF 11 ER stress inhibits mTORC2 and Akt signaling through GSK-3-mediated phosphorylation of rictor. Sci Signal. 2011 Feb 22;4(161):ra10.
REF 12 Hsp70 associates with Rictor and is required for mTORC2 formation and activity. Biochem Biophys Res Commun. 2008 Aug 8;372(4):578-83.

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