Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T85616 Target Info
Target Name Thioredoxin (TXN)
Synonyms Trx; TRX1; TRDX; Surface-associated sulphydryl protein; Surface associated sulphydryl protein; SASP; ATL-derived factor; ADF
Target Type Clinical trial Target
Gene Name TXN
UniProt ID
THIO_HUMAN 
Target Interacting Proteins  Top
Kinases [+] 1 Kinases +
Interacting Target Name Apoptosis signal-regulating kinase 1 (MAP3K5) Clinical trial Target Interacting Protein Info
UniProt ID
M3K5_HUMAN 
Synonyms Mitogen-activated protein kinase kinase kinase 5; MEKK5; MEKK 5; MEK kinase 5; MAPKKK5; MAPK/ERK kinase kinase 5; ASK-1; ASK1
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Affinity Capture-Western [5]
6 Affinity Capture-Western [6]
7 Affinity Capture-Western [7]
8 Affinity Capture-Western [8]
9 Reconstituted Complex [1]
10 Reconstituted Complex [5]
11 Yeast two hybrid [5]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Glucocorticoid receptor (NR3C1) Successful Target Interacting Protein Info
UniProt ID
GCR_HUMAN 
Synonyms Nuclear receptor subfamily 3 group C member 1; GRL; GR; Glucocorticoid receptor; Alpha-A
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [9]
2 Yeast two hybrid [10]
Peptidases [+] 1 Peptidases +
Interacting Target Name JUN activation domain binding protein (COPS5) Literature-reported Target Interacting Protein Info
UniProt ID
CSN5_HUMAN 
Synonyms Signalosome subunit 5; SGN5; Jun activation domain-binding protein 1; JAB1; CSN5; COP9 signalosome complex subunit 5
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-Western [12]
3 Fluorescence Resonance Energy Transfer [12]
Other proteins [+] 1 Other proteins +
Interacting Target Name Vitamin D3 up-regulated protein 1 (VDUP1) Literature-reported Target Interacting Protein Info
UniProt ID
TXNIP_HUMAN 
Synonyms Vitamin D(3) up-regulating protein-1; Thioredoxin-interacting protein; Thioredoxin-binding protein 2
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-MS [13]
2 Affinity Capture-Western [14]
3 Affinity Capture-Western [7]
4 Affinity Capture-Western [15]
5 Affinity Capture-Western [16]
6 Affinity Capture-Western [17]
7 Co-crystal Structure [18]
8 Reconstituted Complex [19]
9 Reconstituted Complex [20]
10 Reconstituted Complex [21]
11 Yeast two hybrid [19]
12 Yeast two hybrid [22]
References  Top
REF 1 Thioredoxin promotes ASK1 ubiquitination and degradation to inhibit ASK1-mediated apoptosis in a redox activity-independent manner. Circ Res. 2002 Jun 28;90(12):1259-66.
REF 2 Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress. EMBO J. 2001 Nov 1;20(21):6028-36.
REF 3 Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1. Mol Cell Biol. 2007 Dec;27(23):8152-63.
REF 4 DJ-1 protects against oxidative damage by regulating the thioredoxin/ASK1 complex. Neurosci Res. 2010 Jul;67(3):203-8.
REF 5 Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J. 1998 May 1;17(9):2596-606.
REF 6 Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function. J Immunol. 2000 Jun 15;164(12):6287-95.
REF 7 Involvement of thioredoxin-binding protein 2 in the antitumor activity of CD437. Cancer Sci. 2008 Dec;99(12):2485-90.
REF 8 TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1. Cell Rep. 2017 Nov 28;21(9):2447-2457.
REF 9 Interaction of mitochondrial thioredoxin with glucocorticoid receptor and NF-kappaB modulates glucocorticoid receptor and NF-kappaB signalling in HEK-293 cells. Biochem J. 2009 Aug 27;422(3):521-31.
REF 10 Direct association with thioredoxin allows redox regulation of glucocorticoid receptor function. J Biol Chem. 1999 Jan 29;274(5):3182-8.
REF 11 Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell. 2010 Dec 10;143(6):951-65.
REF 12 Thioredoxin modulates activator protein 1 (AP-1) activity and p27Kip1 degradation through direct interaction with Jab1. Oncogene. 2004 Nov 25;23(55):8868-75.
REF 13 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 14 Thioredoxin regulates adipogenesis through thioredoxin-interacting protein (Txnip) protein stability. J Biol Chem. 2011 Aug 19;286(33):29139-45.
REF 15 Regulation of the bioavailability of thioredoxin in the lens by a specific thioredoxin-binding protein (TBP-2). Exp Eye Res. 2007 Aug;85(2):270-9.
REF 16 A critical role for thioredoxin-interacting protein in diabetes-related impairment of angiogenesis. Diabetes. 2014 Feb;63(2):675-87.
REF 17 Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins. J Biol Chem. 2009 Sep 11;284(37):24996-5003.
REF 18 The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein. Nat Commun. 2014;5:2958.
REF 19 Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression. J Biol Chem. 1999 Jul 30;274(31):21645-50.
REF 20 The interaction of thioredoxin with Txnip. Evidence for formation of a mixed disulfide by disulfide exchange. J Biol Chem. 2006 Aug 4;281(31):21884-91.
REF 21 Thioredoxin-binding protein-2-like inducible membrane protein is a novel vitamin D3 and peroxisome proliferator-activated receptor (PPAR)gamma ligand target protein that regulates PPARgamma signaling. Endocrinology. 2006 Feb;147(2):733-43.
REF 22 A possible interaction of thioredoxin with VDUP1 in HeLa cells detected in a yeast two-hybrid system. Biochem Biophys Res Commun. 2000 May 19;271(3):796-800.

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