Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T93105 | Target Info | |||
| Target Name | Presenilin 1 (PSEN1) | ||||
| Synonyms | S182 protein; Protein S182; Presenilin-1; PSNL1; PS1; PS-1; AD3 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | PSEN1 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Acyltransferases | [+] 1 Acyltransferases | + | |||
| Interacting Target Name | TNF receptor-associated factor 6 (TRAF6) | Literature-reported Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | RNF85; RING-type E3 ubiquitin transferase TRAF6; RING finger protein 85; Interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Co-localization | [2] | |||
| Peptidases | [+] 1 Peptidases | + | |||
| Interacting Target Name | Presenilin 2 (PSEN2) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | STM-2; STM2; PSNL2; PS-2; Presenilin-2; E5-1; AD5; AD4; AD3LP | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [3] | |||
| 2 | Affinity Capture-Western | [4] | |||
| 3 | Yeast two hybrid | [5] | |||
| Other proteins | [+] 2 Other proteins | + | |||
| Interacting Protein Name | Nicastrin (NCSTN) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | ATAG1874 | ||||
| Evidence Score (E-score) | 5 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [6] | |||
| 2 | Affinity Capture-Western | [3] | |||
| 3 | Affinity Capture-Western | [4] | |||
| 4 | Affinity Capture-Western | [7] | |||
| 5 | Co-fractionation | [7] | |||
| Interacting Target Name | Beta-catenin (CTNNB1) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [8] | |||
| 2 | Reconstituted Complex | [9] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Association between Presenilin-1 and TRAF6 modulates regulated intramembrane proteolysis of the p75NTR neurotrophin receptor. J Neurochem. 2009 Jan;108(1):216-30. | ||||
| REF 2 | TRAF6 stimulates the tumor-promoting effects of TGF type I receptor through polyubiquitination and activation of presenilin 1. Sci Signal. 2014 Jan 7;7(307):ra2. | ||||
| REF 3 | APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes. J Biol Chem. 2003 Feb 28;278(9):7374-80. | ||||
| REF 4 | Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity. Neurobiol Dis. 2004 Nov;17(2):260-72. | ||||
| REF 5 | Interactome mapping suggests new mechanistic details underlying Alzheimer's disease. Genome Res. 2011 Mar;21(3):364-76. | ||||
| REF 6 | Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates. Neurobiol Dis. 2003 Nov;14(2):194-204. | ||||
| REF 7 | Active gamma-secretase complexes contain only one of each component. J Biol Chem. 2007 Nov 23;282(47):33985-93. | ||||
| REF 8 | Direct association of presenilin-1 with beta-catenin. FEBS Lett. 1998 Aug 14;433(1-2):73-7. | ||||
| REF 9 | A structural switch of presenilin 1 by glycogen synthase kinase 3beta-mediated phosphorylation regulates the interaction with beta-catenin and its nuclear signaling. J Biol Chem. 2007 May 11;282(19):14083-93. | ||||
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