Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T97196 Target Info
Target Name ATM serine/threonine kinase (ATM)
Synonyms Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated
Target Type Clinical trial Target
Gene Name ATM
Biochemical Class Kinase
UniProt ID
ATM_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 2 Acid anhydride hydrolases +
Interacting Protein Name Structural maintenance of chromosomes protein 1A (SMC1A) Interacting Protein Interacting Protein Info
UniProt ID
SMC1A_HUMAN 
Synonyms CDLS2; DXS423E; SB1.8; SMC1; SMC1L1; SMC1alpha; SMCB
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [2]
3 Reconstituted Complex [1]
Interacting Protein Name Bloom syndrome protein (BLM) Interacting Protein Interacting Protein Info
UniProt ID
BLM_HUMAN 
Synonyms BS; RECQ2; RECQL2; RECQL3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Co-purification [4]
Acyltransferases [+] 2 Acyltransferases +
Interacting Protein Name Breast cancer type 1 susceptibility protein (BRCA1) Interacting Protein Interacting Protein Info
UniProt ID
BRCA1_HUMAN 
Synonyms BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Affinity Capture-Western [6]
3 Affinity Capture-Western [7]
4 Biochemical Activity [5]
5 Protein-peptide [8]
6 Reconstituted Complex [5]
7 Reconstituted Complex [6]
8 Reconstituted Complex [9]
Interacting Target Name Transcription intermediary factor 1-beta (TRIM28) Literature-reported Target Interacting Protein Info
UniProt ID
TIF1B_HUMAN 
Synonyms Tripartite motif-containing protein 28; TIF1-beta; TIF1B; RNF96; RING-type E3 ubiquitin transferase TIF1-beta; RING finger protein 96; Nuclear corepressor KAP-1; KRIP-1; KRAB-interacting protein 1; KRAB-associated protein 1; KAP-1; KAP1; E3 SUMO-protein ligase TRIM28
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Affinity Capture-Western [11]
3 Co-localization [11]
Ester hydrolases [+] 2 Ester hydrolases +
Interacting Protein Name DNA endonuclease RBBP8 (RBBP8) Interacting Protein Interacting Protein Info
UniProt ID
CTIP_HUMAN 
Synonyms COM1; CTIP; JWDS; RIM; SAE2; SCKL2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Protein-peptide [8]
3 Reconstituted Complex [12]
Interacting Protein Name Double-strand break repair protein MRE11 (MRE11) Interacting Protein Interacting Protein Info
UniProt ID
MRE11_HUMAN 
Synonyms ATLD; HNGS1; MRE11; MRE11B
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Protein-peptide [8]
Eukaryotic initiation factors [+] 1 Eukaryotic initiation factors +
Interacting Target Name Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) Literature-reported Target Interacting Protein Info
UniProt ID
4EBP1_HUMAN 
Synonyms Phosphorylated heat- andacid-stable protein regulated by insulin 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I; eIF4E-binding protein 1; 4E-BP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [14]
2 Protein-peptide [8]
Histones [+] 1 Histones +
Interacting Target Name Gamma-Histone H2AX (H2AFX) Literature-reported Target Interacting Protein Info
UniProt ID
H2AX_HUMAN 
Synonyms Phosphorylation of H2AX; Histone H2AX; Histone H2A.x; H2AX; H2a/x
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Affinity Capture-Western [15]
3 Biochemical Activity [16]
Kinases [+] 6 Kinases +
Interacting Target Name Tyrosine-protein kinase ABL1 (ABL) Successful Target Interacting Protein Info
UniProt ID
ABL1_HUMAN 
Synonyms Proto-oncogene tyrosine-protein kinase ABL1; Proto-oncogene c-Abl; p150; JTK7; C-ABL; Abl; Abelson tyrosine-protein kinase 1; Abelson murine leukemia viral oncogene homolog 1
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Affinity Capture-Western [18]
3 Affinity Capture-Western [19]
4 Biochemical Activity [20]
5 Biochemical Activity [21]
6 Reconstituted Complex [22]
7 Yeast two hybrid [22]
Interacting Target Name Serine/threonine-protein kinase Chk2 (RAD53) Clinical trial Target Interacting Protein Info
UniProt ID
CHK2_HUMAN 
Synonyms Hucds1; hCds1; CHK2 checkpoint homolog; CHK2; Checkpoint kinase 2; Cds1 homolog; Cds1
Evidence Score (E-score) 6 Experimental Evidences +
1 Biochemical Activity [23]
2 Biochemical Activity [24]
3 Biochemical Activity [25]
4 Biochemical Activity [26]
5 Biochemical Activity [14]
6 Reconstituted Complex [23]
Interacting Target Name Checkpoint kinase-1 (CHK1) Clinical trial Target Interacting Protein Info
UniProt ID
CHK1_HUMAN 
Synonyms Serine/threonine-protein kinase Chk1; CHK1 checkpoint homolog; Chk1; Cell cycle checkpoint kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [27]
2 Protein-peptide [8]
Interacting Target Name DNA-dependent protein kinase catalytic (PRKDC) Clinical trial Target Interacting Protein Info
UniProt ID
PRKDC_HUMAN 
Synonyms P460; HYRC1; HYRC; DNPK1; DNA-PKcs; DNA-PK catalytic subunit; DNA-PK; DNA-dependent protein kinase catalytic subunit; DNA-dependent protein kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [28]
2 Protein-peptide [8]
Interacting Target Name Serine/threonine-protein kinase ATR (FRP1) Clinical trial Target Interacting Protein Info
UniProt ID
ATR_HUMAN 
Synonyms FRAP-related protein 1; Ataxia telangiectasia and Rad3-related protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [29]
2 Protein-peptide [8]
Interacting Protein Name DNA-directed RNA polymerase II subunit RPB1 (POLR2A) Interacting Protein Interacting Protein Info
UniProt ID
RPB1_HUMAN 
Synonyms POLR2; POLRA; RPB1; RPBh1; RPO2; RPOL2; RpIILS; hRPB220; hsRPB1
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [21]
2 Co-localization [30]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 20 Experimental Evidences +
1 Biochemical Activity [31]
2 Biochemical Activity [20]
3 Biochemical Activity [24]
4 Biochemical Activity [8]
5 Biochemical Activity [23]
6 Biochemical Activity [26]
7 Biochemical Activity [14]
8 Biochemical Activity [32]
9 Biochemical Activity [33]
10 Biochemical Activity [34]
11 Biochemical Activity [35]
12 Biochemical Activity [36]
13 Biochemical Activity [37]
14 Biochemical Activity [38]
15 Co-localization [39]
16 Protein-peptide [8]
17 Reconstituted Complex [40]
18 Reconstituted Complex [23]
19 Reconstituted Complex [31]
20 Reconstituted Complex [41]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name Telomeric repeat-binding factor 1 (TERF1) Literature-reported Target Interacting Protein Info
UniProt ID
TERF1_HUMAN 
Synonyms TTAGGG repeat-binding factor 1; TRF1; TRF; TRBF1; Telomeric protein Pin2/TRF1; PIN2; NIMA-interacting protein 2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Biochemical Activity [18]
3 Reconstituted Complex [42]
4 Reconstituted Complex [43]
Other proteins [+] 6 Other proteins +
Interacting Protein Name Nibrin (NBN) Interacting Protein Interacting Protein Info
UniProt ID
NBN_HUMAN 
Synonyms AT.V1; AT.V2; ATV; NBS; NBS1; P95
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Affinity Capture-Western [44]
3 Protein-peptide [8]
4 Reconstituted Complex [13]
Interacting Target Name Tumor suppressor p53-binding protein 1 (TP53BP1) Literature-reported Target Interacting Protein Info
UniProt ID
TP53B_HUMAN 
Synonyms TP53-binding protein 1; p53BP1; p53-binding protein 1; 53BP1
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [45]
2 Biochemical Activity [46]
3 Reconstituted Complex [47]
Interacting Protein Name Cell cycle checkpoint protein RAD17 (RAD17) Interacting Protein Interacting Protein Info
UniProt ID
RAD17_HUMAN 
Synonyms CCYC; HRAD17; R24L; RAD17SP; RAD24
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [48]
2 Affinity Capture-Western [7]
3 Protein-peptide [8]
Interacting Protein Name Mediator of DNA damage checkpoint protein 1 (MDC1) Interacting Protein Interacting Protein Info
UniProt ID
MDC1_HUMAN 
Synonyms NFBD1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [49]
2 Biochemical Activity [50]
Interacting Protein Name Peroxisomal targeting signal 1 receptor (PEX5) Interacting Protein Interacting Protein Info
UniProt ID
PEX5_HUMAN 
Synonyms PBD2A; PBD2B; PTS1.BP; PTS1R; PXR1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [51]
2 Yeast two hybrid [52]
Interacting Protein Name DNA repair protein complementing XP-C cells (XPC) Interacting Protein Interacting Protein Info
UniProt ID
XPC_HUMAN 
Synonyms RAD4; XP3; XPCC; p125
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [53]
2 Co-localization [54]
References  Top
REF 1 Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev. 2002 Mar 1;16(5):560-70.
REF 2 SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev. 2002 Mar 1;16(5):571-82.
REF 3 Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM. J Biol Chem. 2002 Aug 23;277(34):30515-23.
REF 4 BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev. 2000 Apr 15;14(8):927-39.
REF 5 Role for ATM in DNA damage-induced phosphorylation of BRCA1. Cancer Res. 2000 Jun 15;60(12):3299-304.
REF 6 Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science. 1999 Nov 5;286(5442):1162-6.
REF 7 Functional interaction between FOXO3a and ATM regulates DNA damage response. Nat Cell Biol. 2008 Apr;10(4):460-7.
REF 8 Substrate specificities and identification of putative substrates of ATM kinase family members. J Biol Chem. 1999 Dec 31;274(53):37538-43.
REF 9 Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev. 2000 Dec 1;14(23):2989-3002.
REF 10 MAGE-C2 promotes growth and tumorigenicity of melanoma cells, phosphorylation of KAP1, and DNA damage repair. J Invest Dermatol. 2013 Mar;133(3):759-767.
REF 11 Chloroquine triggers Epstein-Barr virus replication through phosphorylation of KAP1/TRIM28 in Burkitt lymphoma cells. PLoS Pathog. 2017 Mar 1;13(3):e1006249.
REF 12 Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature. 2000 Jul 13;406(6792):210-5.
REF 13 Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature. 2005 Mar 31;434(7033):605-11.
REF 14 Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/threonine protein kinase. J Biol Chem. 2000 Mar 17;275(11):7803-10.
REF 15 A hypoxia-responsive TRAF6-ATM-H2AX signalling axis promotes HIF1 activation, tumorigenesis andmetastasis. Nat Cell Biol. 2017 Jan;19(1):38-51.
REF 16 Vpr-binding protein antagonizes p53-mediated transcription via direct interaction with H3 tail. Mol Cell Biol. 2012 Feb;32(4):783-96.
REF 17 Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl. J Biol Chem. 1999 Apr 30;274(18):12748-52.
REF 18 Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks. J Biol Chem. 2001 Aug 3;276(31):29282-91.
REF 19 A positive role for c-Abl in Atm and Atr activation in DNA damage response. Cell Death Differ. 2011 Jan;18(1):5-15.
REF 20 Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status. Cancer Res. 2007 Apr 1;67(7):3010-7.
REF 21 Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. Nature. 1997 May 29;387(6632):516-9.
REF 22 Interaction between ATM protein and c-Abl in response to DNA damage. Nature. 1997 May 29;387(6632):520-3.
REF 23 Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science. 2004 Apr 2;304(5667):93-6.
REF 24 ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science. 2005 Apr 22;308(5721):551-4.
REF 25 Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10389-94.
REF 26 Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity. J Biol Chem. 2000 Apr 7;275(14):10342-8.
REF 27 Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell. 2003 Mar;3(3):247-58.
REF 28 Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation. J Biol Chem. 1999 Sep 3;274(36):25571-5.
REF 29 ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J. 2006 Dec 13;25(24):5775-82.
REF 30 ATM regulates NF-B-dependent immediate-early genes via RelA Ser 276 phosphorylation coupled to CDK9 promoter recruitment. Nucleic Acids Res. 2014 Jul;42(13):8416-32.
REF 31 ATM associates with and phosphorylates p53: mapping the region of interaction. Nat Genet. 1998 Dec;20(4):398-400.
REF 32 Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev. 2001 Jul 15;15(14):1833-44.
REF 33 EDD inhibits ATM-mediated phosphorylation of p53. J Biol Chem. 2011 Apr 29;286(17):14972-82.
REF 34 ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage. J Biol Chem. 2010 Feb 12;285(7):4909-19.
REF 35 ATM-mediated phosphorylation of SOG1 is essential for the DNA damage response in Arabidopsis. EMBO Rep. 2013 Sep;14(9):817-22.
REF 36 ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat Cell Biol. 2014 Sep;16(9):864-75.
REF 37 ATDC/TRIM29 phosphorylation by ATM/MAPKAP kinase 2 mediates radioresistance in pancreatic cancer cells. Cancer Res. 2014 Mar 15;74(6):1778-88.
REF 38 Double strand break repair by homologous recombination is regulated by cell cycle-independent signaling via ATM in human glioma cells. J Biol Chem. 2004 Apr 9;279(15):15402-10.
REF 39 The DNA Damage Response Regulates RAG1/2 Expression in Pre-B Cells through ATM-FOXO1 Signaling. J Immunol. 2016 Oct 1;197(7):2918-29.
REF 40 Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression. Mol Cell Biol. 2005 Jan;25(2):661-70.
REF 41 BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage. J Biol Chem. 2004 Jul 23;279(30):31251-8.
REF 42 Tel2 regulates the stability of PI3K-related protein kinases. Cell. 2007 Dec 28;131(7):1248-59.
REF 43 The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. PLoS Biol. 2004 Aug;2(8):E240.
REF 44 Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1. Mol Cell. 2012 May 11;46(3):351-61.
REF 45 Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. J Biol Chem. 2003 May 30;278(22):19579-82.
REF 46 S1219 residue of 53BP1 is phosphorylated by ATM kinase upon DNA damage and required for proper execution of DNA damage response. Biochem Biophys Res Commun. 2009 Jan 2;378(1):32-6.
REF 47 DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol. 2002 Dec;4(12):993-7.
REF 48 ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. Nature. 2001 Jun 21;411(6840):969-74.
REF 49 MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature. 2003 Feb 27;421(6926):961-6.
REF 50 Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science. 2007 Dec 7;318(5856):1637-40.
REF 51 ATM functions at the peroxisome to induce pexophagy in response to ROS. Nat Cell Biol. 2015 Oct;17(10):1259-1269.
REF 52 Localization of a portion of extranuclear ATM to peroxisomes. J Biol Chem. 1999 Nov 26;274(48):34277-82.
REF 53 NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites. DNA Repair (Amst). 2013 Apr 1;12(4):273-83.
REF 54 Human SNF5/INI1, a component of the human SWI/SNF chromatin remodeling complex, promotes nucleotide excision repair by influencing ATM recruitment and downstream H2AX phosphorylation. Mol Cell Biol. 2009 Dec;29(23):6206-19.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.