Target Regulator(s) Information (Transcription Factor)
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T00176 | Target Info | |||
| Target Name | Ubiquitin-protein ligase E3 Mdm2 (MDM2) | ||||
| Synonyms | RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | MDM2 | ||||
| Biochemical Class | Acyltransferase | ||||
| UniProt ID | |||||
| The Transcription Factors (TFs) Regulating This Target | Top | ||||
|---|---|---|---|---|---|
| TF Name | Tumor suppressor p53 (TP53) homotetramer | ||||
| Classification | Superclass | beta-Scaffold Factors with Minor Groove Contacts | |||
| Class | p53 | ||||
| Family | p53 | ||||
| Regulation Mechanism | The mouse MDM2 gene contains two promoters: one is located upstream to the gene and is active in the absence of TP53, the other resides within the first intron and requires TP53 for transcriptional activity. | [1] | |||
| Evidence Score (E-score) | 2 | + | |||
| 1 | Chromatin Immunoprecipitation Assay | [2] | |||
| 2 | DNA Binding Assay | [1] | |||
| UniProt ID | |||||
| Sequence |
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP
DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD |
||||
| The Genes (Co-regulated by This TF) Grouped Based on Their Biochemical Classes | |||||
| Acyltransferases | [+] 1 Acyltransferases Co-regulated By This TF | + | |||
| 1 | Ubiquitin-protein ligase E3 Mdm2 (MDM2) | Clinical trial Target | Target Info | [1] | |
| Apoptosis regulators | [+] 1 Apoptosis regulators Co-regulated By This TF | + | |||
| 1 | Apoptosis regulator Bcl-2 (BCL-2) | Successful Target | Target Info | [3] | |
| Caveolin proteins | [+] 1 Caveolin proteins Co-regulated By This TF | + | |||
| 1 | Caveolin 1 (CAV1) | Literature-reported Target | Target Info | [4] | |
| Cyclins | [+] 1 Cyclins Co-regulated By This TF | + | |||
| 1 | Proliferating cell nuclear antigen (PCNA) | Clinical trial Target | Target Info | [5] | |
| Ester hydrolases | [+] 2 Ester hydrolases Co-regulated By This TF | + | |||
| 1 | M-phase inducer phosphatase 3 (MPIP3) | Literature-reported Target | Target Info | [6] | |
| 2 | Phosphatase and tensin homolog (PTEN) | Literature-reported Target | Target Info | [7] | |
| Growth factor binding | [+] 1 Growth factor binding Co-regulated By This TF | + | |||
| 1 | Insulin-like growth factor-binding protein 3 (IGFBP3) | Clinical trial Target | Target Info | [8] | |
| Methyltransferases | [+] 1 Methyltransferases Co-regulated By This TF | + | |||
| 1 | DNA [cytosine-5]-methyltransferase 1 (DNMT1) | Clinical trial Target | Target Info | [9] | |
| Peptidases | [+] 2 Peptidases Co-regulated By This TF | + | |||
| 1 | Caspase-6 (CASP6) | Patented-recorded Target | Target Info | [10] | |
| 2 | Matrix metalloproteinase-2 (MMP-2) | Successful Target | Target Info | [11] | |
| Small GTPases | [+] 1 Small GTPases Co-regulated By This TF | + | |||
| 1 | GTPase HRas (HRAS) | Literature-reported Target | Target Info | [12] | |
| Transcription factors | [+] 1 Transcription factors Co-regulated By This TF | + | |||
| 1 | Cyclic-AMP-dependent transcription factor ATF-3 (ATF3) | Literature-reported Target | Target Info | [13] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A functional p53-responsive intronic promoter is contained within the human mdm2 gene. Nucleic Acids Res. 1995 Jul 25;23(14):2584-92. | ||||
| REF 2 | Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity. Nat Struct Mol Biol. 2017 Jul;24(7):578-587. | ||||
| REF 3 | Negative regulation of bcl-2 expression by p53 in hematopoietic cells. Oncogene. 2001 Jan 11;20(2):240-51. | ||||
| REF 4 | p53 regulates caveolin gene transcription, cell cholesterol, and growth by a novel mechanism. Biochemistry. 2000 Feb 29;39(8):1966-72. | ||||
| REF 5 | Wild-type human p53 transactivates the human proliferating cell nuclear antigen promoter. Mol Cell Biol. 1995 Dec;15(12):6785-93. | ||||
| REF 6 | Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53. Genes Dev. 1998 Jul 15;12(14):2102-7. | ||||
| REF 7 | Regulation of PTEN transcription by p53. Mol Cell. 2001 Aug;8(2):317-25. | ||||
| REF 8 | Induction of the growth inhibitor IGF-binding protein 3 by p53. Nature. 1995 Oct 19;377(6550):646-9. | ||||
| REF 9 | p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding. Cancer Res. 2003 Oct 15;63(20):6579-82. | ||||
| REF 10 | Apoptotic threshold is lowered by p53 transactivation of caspase-6. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9492-7. | ||||
| REF 11 | Transcriptional activation by p53 of the human type IV collagenase (gelatinase A or matrix metalloproteinase 2) promoter. Mol Cell Biol. 1997 Nov;17(11):6330-8. | ||||
| REF 12 | Transcriptional regulation of the c-H-ras1 gene by the P53 protein is implicated in the development of human endometrial and ovarian tumours. Oncogene. 1998 Jun 11;16(23):3013-7. | ||||
| REF 13 | Transcriptional activation of the human stress-inducible transcriptional repressor ATF3 gene promoter by p53. Biochem Biophys Res Commun. 2002 Oct 11;297(5):1302-10. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.