Target Validation Information
TTD ID T35640
Target Name Integrin alpha-L (ITGAL)
Type of Target
Successful
Drug Potency against Target A-286982 Drug Info IC50 = 44 nM [2]
BMS-587101 Drug Info IC50 = 150 nM [1]
References
REF 1 Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-(... J Med Chem. 2010 May 13;53(9):3814-30.
REF 2 Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5269-73.

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