Drug Information

Drug General Information
Drug ID
D00SEC
Former ID
DIB018805
Drug Name
aloisine
Synonyms
IN1538; RP106
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541209]
Structure
Download
2D MOL
Formula
C17H19N3O
InChI
InChI=1S/C17H19N3O/c1-3-4-5-14-15(12-6-8-13(21-2)9-7-12)20-17-16(14)18-10-11-19-17/h6-11H,3-5H2,1-2H3,(H,19,20)
InChIKey
WVMANZPBOBRWCB-UHFFFAOYSA-N
PubChem Compound ID
3641059
PubChem Substance ID
4963298, 9824244, 11108155, 16146302, 26758199, 37836728, 48095584, 51172427, 53800978, 57356450, 71750028, 85787192, 99302622, 103278247, 112073773, 162253865, 163122568, 163688629, 164835226, 175607455, 178102546, 179230463, 184600767, 196376753, 204380521, 208265184, 226458815, 244125054, 252451179
Target and Pathway
Target(s) Zap70 tyrosine kinase Target Info Inhibitor [531779]
Focal adhesion kinase-2 Target Info Inhibitor [531779]
Cell division protein kinase 2 Target Info Inhibitor [531779]
KEGG Pathway Ras signaling pathway
NF-kappa B signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
Primary immunodeficiencyhsa04020:Calcium signaling pathway
Chemokine signaling pathway
Leukocyte transendothelial migration
GnRH signaling pathway
Hepatitis Bhsa04068:FoxO signaling pathway
Cell cycle
Oocyte meiosis
p53 signaling pathway
PI3K-Akt signaling pathway
Progesterone-mediated oocyte maturation
Hepatitis B
Measles
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Prostate cancer
Small cell lung cancer
NetPath Pathway TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
PANTHER Pathway T cell activationP00031:Inflammation mediated by chemokine and cytokine signaling pathway
Integrin signalling pathway
CCKR signaling map STP00059:p53 pathway
p53 pathway feedback loops 2
Pathway Interaction Database TCR signaling in na&#xef
TCR signaling in na&#xef
Class I PI3K signaling eventsendothelinpathway:Endothelins
LPA receptor mediated events
Coregulation of Androgen receptor activity
Osteopontin-mediated events
IL2-mediated signaling events
CXCR4-mediated signaling events
Integrins in angiogenesis
Signaling events mediated by VEGFR1 and VEGFR2
Alpha-synuclein signaling
FGF signaling pathway
Alpha4 beta1 integrin signaling eventssmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by PRL
p73 transcription factor network
E2F transcription factor network
ATR signaling pathway
mTOR signaling pathway
FoxO family signaling
FOXM1 transcription factor network
BARD1 signaling events
p53 pathway
Regulation of retinoblastoma protein
Reactome Translocation of ZAP-70 to Immunological synapse
Generation of second messenger moleculesR-HSA-391160:Signal regulatory protein (SIRP) family interactions
VEGFA-VEGFR2 Pathway
Interleukin-2 signalingR-HSA-1538133:G0 and Early G1
Activation of ATR in response to replication stress
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Processing of DNA double-strand break ends
G2 Phase
Orc1 removal from chromatin
Cyclin E associated events during G1/S transition
Cyclin A/B1 associated events during G2/M transition
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Meiotic recombination
Factors involved in megakaryocyte development and platelet production
WikiPathways TCR Signaling Pathway
Interferon type I signaling pathways
Inflammatory Response Pathway
JAK/STAT
T-Cell Receptor and Co-stimulatory Signaling
TCR signalingWP69:TCR Signaling Pathway
IL-2 Signaling Pathway
Signaling of Hepatocyte Growth Factor Receptor
Apoptosis-related network due to altered Notch3 in ovarian cancer
Interleukin-2 signaling
Nifedipine Activity
BDNF signaling pathway
Oncostatin M Signaling Pathway
Prostate Cancer
IL-7 Signaling Pathway
Signal regulatory protein (SIRP) family interactionsWP707:DNA Damage Response
ID signaling pathway
DNA Replication
G1 to S cell cycle control
M/G1 Transition
S Phase
Meiotic Recombination
Aryl Hydrocarbon Receptor
ATM Signaling Pathway
Retinoblastoma (RB) in Cancer
Spinal Cord Injury
Integrated Pancreatic Cancer Pathway
Signaling Pathways in Glioblastoma
TSH signaling pathway
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Synthesis of DNA
Regulation of DNA replication
Mitotic G2-G2/M phases
Mitotic G1-G1/S phases
Factors involved in megakaryocyte development and platelet production
Cell Cycle
APC/C-mediated degradation of cell cycle proteins
Cell Cycle Checkpoints
miRNA Regulation of DNA Damage Response
References
Ref 541209(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5923).
Ref 531779Identification of binding specificity-determining features in protein families. J Med Chem. 2012 Mar 8;55(5):1926-39.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.