Drug Information

Drug General Information
Drug ID
D01WJZ
Former ID
DNC012338
Drug Name
MAZAPERTINE
Drug Type
Small molecular drug
Indication Discovery agent Discontinued in Phase 2 [545274]
Structure
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2D MOL

3D MOL
Formula
C26H35N3O2
Canonical SMILES
CC(C)OC1=CC=CC=C1N2CCN(CC2)CC3=CC=CC(=C3)C(=O)N4CCCCC4
InChI
1S/C26H35N3O2/c1-21(2)31-25-12-5-4-11-24(25)28-17-15-27(16-18-28)20-22-9-8-10-23(19-22)26(30)29-13-6-3-7-14-29/h4-5,8-12,19,21H,3,6-7,13-18,20H2,1-2H3
InChIKey
ZKZFPRUSWCYSGT-UHFFFAOYSA-N
PubChem Compound ID
60820
Target and Pathway
Target(s) Alpha-1D adrenergic receptor Target Info Inhibitor [533800]
5-hydroxytryptamine 1A receptor Target Info Inhibitor [533800]
5-hydroxytryptamine 2A receptor Target Info Inhibitor [533800]
Alpha-2B adrenergic receptor Target Info Inhibitor [533800]
D(2) dopamine receptor Target Info Inhibitor [533800]
Alpha-2A adrenergic receptor Target Info Inhibitor [533800]
Alpha-1B adrenergic receptor Target Info Inhibitor [533800]
D(3) dopamine receptor Target Info Inhibitor [533800]
Alpha-1A adrenergic receptor Target Info Inhibitor [533800]
Alpha-2C adrenergic receptor Target Info Inhibitor [533800]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretionhsa04024:cAMP signaling pathway
Serotonergic synapsehsa04020:Calcium signaling pathway
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04015:Rap1 signaling pathway
cAMP signaling pathway
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholismhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Salivary secretionhsa04080:Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04020:Calcium signaling pathway
AMPK signaling pathway
Salivary secretionhsa04022:cGMP-PKG signaling pathway
NetPath Pathway IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Pathway Interaction Database LPA receptor mediated events
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling eventsR-HSA-390696:Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
G alpha (i) signalling events
G alpha (z) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling eventsR-HSA-390696:Adrenoceptors
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (z) signalling events
Surfactant metabolismR-HSA-390696:Adrenoceptors
G alpha (12/13) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
Surfactant metabolism
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
GPCRs, OtherWP58:Monoamine GPCRs
Platelet Aggregation (Plug Formation)
GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
Nicotine Activity on Dopaminergic NeuronsWP58:Monoamine GPCRs
Integration of energy metabolism
GPCR downstream signalingWP58:Monoamine GPCRs
Vitamin D Receptor Pathway
AMPK SignalingWP58:Monoamine GPCRs
Nicotine Activity on Dopaminergic Neurons
Endothelin Pathways
References
Ref 545274Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002662)
Ref 533800J Med Chem. 1994 Apr 15;37(8):1060-2.A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects.

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