Target Information

Target General Infomation
Target ID
T78709
Former ID
TTDS00098
Target Name
5-hydroxytryptamine 1A receptor
Gene Name
HTR1A
Synonyms
5-HT-1A; 5-HT1A; 5-HT1A receptor; 5-hydroxytryptamine receptor 1A; G-21; Serotonin receptor; Serotonin receptor 1A; HTR1A
Target Type
Successful
Disease Alzheimer disease [ICD9: 331; ICD10: G30]
Addiction [ICD code not available]
Aggressive non-hodgkin's lymphoma [ICD9: 200, 201, 202, 202.8, 208.9; ICD10: C81, C81-C86, C82-C85, C91-C95]
Anxiety disorder [ICD9: 300, 311; ICD10: F32, F40-F42]
Alzheimer disease; Peripheral sensory neuropathies; Lateral sclerosis [ICD9:331.0, 356.0, 356.8; ICD10: G30, G64, G90.0, G12.2]
Bulimia nervosa; Severe mood disorders [ICD9: 296, 307.51; ICD10: F30-F39, F50.2]
Coronary artery disease [ICD9: 410-414, 429.2; ICD10: I20-I25]
Cervical dystonia; Spasm [ICD9:333.83, 728.85; ICD10: G24.3, R25.2]
Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10: F01-F07, F04, F05, R41.3]
Depression [ICD9: 311; ICD10: F30-F39]
Eating disorder [ICD9: 278, 307.5, 401, 428.0; ICD10: E66, F50, I10-I16, I50]
Female sexual dysfunction [ICD9: 302.7; ICD10: F52]
Generalized anxiety disorder; Social phobia [ICD9: 300, 300.02, 300.23; ICD10: F40-F42, F40.1, F41.1, F93.2]
Generalized anxiety disorder [ICD9: 300, 300.02, 311; ICD10: F32, F40-F42, F41.1]
Hypoactive sexual desire disorder [ICD10: F52.0]
Hypertension [ICD9: 401; ICD10: I10-I16]
Insomnia [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52; ICD10: F51.0, G47.0]
Mood disorder [ICD10: F30-F39]
Migraine [ICD9: 346; ICD10: G43]
Major depressive disorder; Episode; Anxiety [ICD9: 296.2, 296.3, 300; ICD10: F32, F32.2, F32.3, F33, F40-F42]
Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10: F32, F33, M32]
Post-traumatic stress disorder [ICD9: 309.81; ICD10: F43.1]
Pain [ICD9: 338, 356.0, 356.8,780; ICD10: G64, G90.0, R52, G89]
Psychiatric disorder [ICD9: 290-319; ICD10: F01-F99]
Parkinson's disease [ICD9: 332; ICD10: G20]
Psychotic disorders [ICD9: 290-299; ICD10: F20-F29]
Premature ejaculation [ICD9: 302.75; ICD10: F52.4]
Schizoaffective disorder; Schizophrenia [ICD9: 295, 295.70; ICD10: F20, F25]
Schizophrenia [ICD9: 295; ICD10: F20]
Severe mood disorders [ICD9: 296; ICD10: F30-F39]
Urinary incontinence [ICD9: 788.3; ICD10: N39.3, N39.4, R32]
Unspecified [ICD code not available]
Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5- hydroxytryptamine release and in the regulation of dopamine and 5- hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
BioChemical Class
GPCR rhodopsin
Target Validation
T78709
UniProt ID
P08908
Sequence
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT
RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN
SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RQ
Drugs and Mode of Action
Drug(s) Buspirone Drug Info Approved Anxiety disorder [536505], [540478]
Flibanserin Drug Info Approved Mood disorder [532651], [542987]
OPC-34712 Drug Info Approved Major depressive disorder [523551], [542651]
TERTATOLOL Drug Info Approved Hypertension [541537], [551871]
Trazodone Drug Info Approved Depression [536306], [539351]
Treximet Drug Info Approved Migraine [538578]
Urapidil Drug Info Approved Hypertension [551871]
Vilazodone Drug Info Approved Major depressive disorder [531783], [542450]
CM-2395 Drug Info Phase 3 Schizophrenia [551513]
Flibanserin Drug Info Phase 3 Female sexual dysfunction [536493], [542987]
LECOZOTAN HYDROCHLORIDE Drug Info Phase 2/3 Cognitive disorders [521788]
Eltoprazine Drug Info Phase 2 Aggressive non-hodgkin's lymphoma [523309]
Ensaculin hydrochloride Drug Info Phase 2 Parkinson's disease [526403]
Mazapertine succinate Drug Info Phase 2 Psychotic disorders [534644]
MIN-117 Drug Info Phase 2 Major depressive disorder [549451]
MN-305 Drug Info Phase 2 Severe mood disorders [536580]
Neu-P11 Drug Info Phase 2 Insomnia [523722]
OPC-14523 Drug Info Phase 2 Bulimia nervosa; Severe mood disorders [536493]
ORG-13011 Drug Info Phase 2 Psychotic disorders [521409]
RP5063 Drug Info Phase 2 Schizoaffective disorder; Schizophrenia [523723]
S-15535 Drug Info Phase 2 Anxiety disorder [539677], [545119]
S-16924 Drug Info Phase 2 Anxiety disorder [525424], [534704], [539033]
SDZ-MAR-327 Drug Info Phase 2 Psychotic disorders [534772], [536463]
SUN N4057 Drug Info Phase 2 Coronary artery disease [521780]
TGBA01AD Drug Info Phase 2 Severe mood disorders [536580]
TGFK08AA-ER Drug Info Phase 2 Generalized anxiety disorder [550644]
TGFK09SD-ER Drug Info Phase 2 Hypoactive sexual desire disorder [550647]
TGWOOAA Drug Info Phase 2 Generalized anxiety disorder; Social phobia [550646]
Zalospirone Drug Info Phase 2 Anxiety disorder [533189], [541119]
1192U90 Drug Info Phase 1 Psychotic disorders [534252]
AV-965 Drug Info Phase 1 Alzheimer disease [548413]
DSP-1053 Drug Info Phase 1 Major depressive disorder [524195]
GSK-958108 Drug Info Phase 1 Premature ejaculation [522300]
OPC-14523 Drug Info Phase 1 Female sexual dysfunction [536493]
SSR-181507 Drug Info Phase 1 Schizophrenia [536463]
Umespirone Drug Info Phase 1 Anxiety disorder [544712]
CM-2236 Drug Info Preclinical Post-traumatic stress disorder [548834]
PD-158771 Drug Info Preclinical Schizophrenia [536463]
LYSERGIC ACID DIETHYLAMIDE Drug Info Withdrawn from market Addiction [526769], [539053]
Bifeprunox Drug Info Discontinued in Phase 3 Schizophrenia [536463]
BMS-181100 Drug Info Discontinued in Phase 3 Psychotic disorders [542913], [544706]
Flesinoxan Drug Info Discontinued in Phase 3 Anxiety disorder [538607], [544790]
Sunepitron Drug Info Discontinued in Phase 3 Discovery agent [545699]
TIOSPIRONE Drug Info Discontinued in Phase 3 Discovery agent [538617], [544679]
Xaliproden Drug Info Discontinued in Phase 3 Alzheimer disease; Peripheral sensory neuropathies; Lateral sclerosis [544941]
Adatanserin Drug Info Discontinued in Phase 2 Severe mood disorders [536580]
ALNESPIRONE Drug Info Discontinued in Phase 2 Anxiety disorder [544887]
AP-521 Drug Info Discontinued in Phase 2 Anxiety disorder [545798]
DU 125530 Drug Info Discontinued in Phase 2 Mood disorder [547248]
GSK163090 Drug Info Discontinued in Phase 2 Major depressive disorder; Episode; Anxiety [548510]
LESOPITRON DIHYDROCHLORIDE Drug Info Discontinued in Phase 2 Mood disorder [544898]
MAZAPERTINE Drug Info Discontinued in Phase 2 Discovery agent [545274]
PRX-00023 Drug Info Discontinued in Phase 2 Severe mood disorders [536580]
REC-15/3079 Drug Info Discontinued in Phase 2 Urinary incontinence [542421], [546820]
Robalzotan Drug Info Discontinued in Phase 2 Anxiety disorder [542212], [546103]
Sarizotan Drug Info Discontinued in Phase 2 Parkinson's disease [536923]
BINOSPIRONE MESYLATE Drug Info Discontinued in Phase 1 Anxiety disorder [544704]
DU-29894 Drug Info Discontinued in Phase 1 Psychotic disorders [544888]
E2101 Drug Info Discontinued in Phase 1 Cervical dystonia; Spasm [547174]
Ebalzotan Drug Info Discontinued in Phase 1 Anxiety disorder [546211]
Eptapirone Drug Info Discontinued in Phase 1 Anxiety disorder [546879]
GR-127607 Drug Info Discontinued in Phase 1 Migraine [545504]
Nerisopam Drug Info Discontinued in Phase 1 Anxiety disorder [544884]
SLV-313 Drug Info Discontinued in Phase 1 Schizophrenia [536463]
SUN-8399 Drug Info Discontinued in Phase 1 Anxiety disorder [544893]
U-93385 Drug Info Discontinued in Phase 1 Anxiety disorder [545114]
1192U90 Drug Info Terminated Schizophrenia [536463]
A-74283 Drug Info Terminated Hypertension [545136]
A-80426 Drug Info Terminated Discovery agent [546043]
Anpirtoline Drug Info Terminated Pain [528148]
BMY-7378 Drug Info Terminated Discovery agent [543289], [544847]
BTS-79018 Drug Info Terminated Schizophrenia [536463]
CGS-18102A Drug Info Terminated Anxiety disorder [545030]
CP-293019 Drug Info Terminated Discovery agent [543340], [546533]
Du-123015 Drug Info Terminated Anxiety disorder [550366]
Gepirone ER Drug Info Terminated Depression [536580]
HT-90B Drug Info Terminated Anxiety disorder [545512]
Ipsapirone Drug Info Terminated Anxiety disorder [467532], [544710]
LY-293284 Drug Info Terminated Anxiety disorder [539199], [545514]
NAN-190 Drug Info Terminated Discovery agent [542320], [544809]
RWJ-25730 Drug Info Terminated Psychotic disorders [544892]
S-14506 Drug Info Terminated Anxiety disorder [539527], [544866]
SDZ 216-525 Drug Info Terminated Discovery agent [542751], [544906]
SDZ-MAR-327 Drug Info Terminated Schizophrenia [536463]
SLV-307 Drug Info Terminated Parkinson's disease [551583]
WAY 100135 Drug Info Terminated Discovery agent [542821], [545080]
WAY-100635 Drug Info Terminated Eating disorder [542914], [545310]
WB-4101 Drug Info Terminated Discovery agent [468117], [545656]
Sunepitron Drug Info Investigative Unspecified [528210]
Inhibitor (3-Chloro-phenyl)-piperazin-1-yl-methanone Drug Info [533476]
(R)-(-)-10-methyl-11-hydroxyaporphine Drug Info [528876]
(R)-11-Amino-2-methoxyaporphine Drug Info [529541]
(R)-2,11-Diaminoaporphine Drug Info [529541]
1,2,3,4-Tetrahydro-naphthalen-2-ylamine Drug Info [533482]
1,6-bis(4-(3-chlorophenyl)piperazin-1-yl)hexane Drug Info [530927]
1,6-bis(4-(3-methoxyphenyl)piperazin-1-yl)hexane Drug Info [530927]
1,6-bis(4-(pyridin-2-yl)piperazin-1-yl)hexane Drug Info [530927]
1,6-bis(4-m-tolylpiperazin-1-yl)hexane Drug Info [530927]
1,6-bis(4-phenylpiperazin-1-yl)hexane Drug Info [530927]
1-((S)-2-aminopropyl)-1H-indazol-6-ol Drug Info [527952]
1-(2,5-Dimethoxy-4-methyl-phenyl)-piperazine Drug Info [533476]
1-(2,5-Dimethoxy-phenyl)-piperazine Drug Info [533476]
1-(2,5-dimethoxyphenyl)propan-2-amine Drug Info [533498]
1-(2-((3-fluorophenoxy)methyl)phenyl)piperazine Drug Info [530474]
1-(2-(2-chlorophenoxy)pyridin-3-yl)piperazine Drug Info [530596]
1-(2-(2-fluorobenzyloxy)phenyl)piperazine Drug Info [530474]
1-(2-(3-fluorophenoxy)phenyl)piperazine Drug Info [530474]
1-(2-(4-fluorophenoxy)phenyl)piperazine Drug Info [530474]
1-(2-(benzyloxy)phenyl)piperazine Drug Info [530474]
1-(2-(phenoxymethyl)phenyl)piperazine Drug Info [530474]
1-(2-Butoxy-phenyl)-piperazine Drug Info [533134]
1-(2-Chloro-phenyl)-piperazine Drug Info [528039]
1-(2-Ethoxy-phenyl)-piperazine Drug Info [533134]
1-(2-Fluoro-phenyl)-piperazine Drug Info [533134]
1-(2-Isopropoxy-phenyl)-piperazine Drug Info [533134]
1-(2-Methoxy-phenyl)-4-propyl-piperazine Drug Info [533873]
1-(2-Methoxy-phenyl)-piperazine Drug Info [528039]
1-(2-methoxyphenyl)-4-pentylpiperazine Drug Info [531189]
1-(2-phenoxyphenyl)piperazine Drug Info [530474]
1-(3-(pentafluorosulfanyl)phenyl)propan-2-amine Drug Info [529013]
1-(3-Fluoro-phenyl)-piperazine Drug Info [533134]
1-(3-Nitro-phenyl)-piperazine Drug Info [533134]
1-(3-Trifluoromethyl-phenyl)-piperazine Drug Info [533476]
1-(4-Bromo-2,5-dimethoxy-phenyl)-piperazine Drug Info [533476]
1-(7-Methoxy-naphthalen-2-yl)-piperazine Drug Info [534528]
1-(benzyloxy)-2-(2-phenylethyl)benzene Drug Info [528493]
1-(benzyloxy)-2-[2-(3-methoxyphenyl)ethyl]benzene Drug Info [528493]
1-Benzyl-4-chroman-2-ylmethyl-piperazine Drug Info [527368]
1-Butyl-4-(2-methoxy-phenyl)-piperazine Drug Info [533873]
1-Ethyl-4-(2-methoxy-phenyl)-piperazine Drug Info [533873]
1-Methyl-1,3-dihydro-indol-2-one Drug Info [526055]
1-Naphthalen-1-yl-piperazine Drug Info [533482]
1-Naphthalen-2-yl-piperazine Drug Info [533482]
1-Propyl-3-(3-trifluoromethyl-phenyl)-pyrrolidine Drug Info [551334]
1-[(3-methoxybenzyl)oxy]-2-(2-phenylethyl)benzene Drug Info [528493]
2-(2'-methyl-biphenyl-3-yl)-ethylamine Drug Info [528780]
2-(2-Amino-propyl)-5-bromo-4-methoxy-phenol Drug Info [533498]
2-(2-chlorophenoxy)-3-(piperidin-4-yl)pyridine Drug Info [530596]
2-(2-fluorophenoxy)-3-(piperidin-4-yl)pyridine Drug Info [530596]
2-(2-Methoxy-phenyl)-1-methyl-ethylamine Drug Info [533498]
2-(2-methoxyphenoxy)-3-(piperidin-4-yl)pyridine Drug Info [530596]
2-(3-Bromophenylthio)-N,N-dimethylethanamine Drug Info [530699]
2-(3-Methoxy-phenyl)-1-methyl-ethylamine Drug Info [533498]
2-(4-Benzyl-piperidin-1-ylmethyl)-chroman-4-one Drug Info [527368]
2-(4-Bromo-2-methoxy-phenyl)-1-methyl-ethylamine Drug Info [533498]
2-(4-Bromo-phenyl)-1-methyl-ethylamine Drug Info [533498]
2-(4-Methyl-piperazin-1-yl)-4-phenyl-pyrimidine Drug Info [551319]
2-(5-Methoxy-1H-indol-3-yl)-1-methyl-ethylamine Drug Info [526713]
2-(Biphenyl-3-ylthio)-N,N-dimethylethanamine Drug Info [530699]
2-Dipropylamino-1,2,3,4-tetrahydro-anthracen-9-ol Drug Info [551246]
2-phenoxy-3-(piperidin-4-yl)pyridine Drug Info [530596]
2-Piperazin-1-yl-benzonitrile Drug Info [533134]
2-Piperazin-1-yl-phenol Drug Info [533476]
2-{[2-(2-phenylethyl)phenoxy]methyl}pyridine Drug Info [528493]
3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-1H-indole Drug Info [532389]
3-(1-Propyl-pyrrolidin-3-yl)-phenol Drug Info [551334]
3-(2-Amino-propyl)-1H-indol-5-ol Drug Info [526713]
3-(2-Benzylamino-ethoxy)-phenol Drug Info [534787]
3-(3-Methanesulfonyl-phenyl)-1-propyl-pyrrolidine Drug Info [551334]
3-(4-Benzyl-piperidin-1-ylmethyl)-chroman-4-one Drug Info [527368]
3-(4-Benzyl-piperidin-1-ylmethyl)-chromen-4-one Drug Info [527368]
3-(piperidin-4-yl)-2-(o-tolyloxy)pyridine Drug Info [530596]
3-Amino-1-(2-amino-5-methoxy-phenyl)-propan-1-one Drug Info [533476]
3-Butyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-ol Drug Info [526822]
3-Ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-ol Drug Info [526822]
3-Naphthalen-1-yl-1-propyl-pyrrolidine Drug Info [551334]
3-Naphthalen-1-yl-pyrrolidine Drug Info [551334]
3-Phenyl-1-propyl-pyrrolidine Drug Info [551334]
3-{[2-(2-phenylethyl)phenoxy]methyl}pyridine Drug Info [528493]
4-(1H-indol-4-yloxy)-1-(isopropylamino)butan-2-ol Drug Info [529018]
4-(2-(2-fluoro-5-methylphenoxy)phenyl)piperidine Drug Info [530474]
4-(2-(2-fluorobenzyloxy)phenyl)piperidine Drug Info [530474]
4-(2-(3-chlorophenoxy)phenyl)piperidine Drug Info [530474]
4-(2-(3-fluorophenoxy)phenyl)piperidine Drug Info [530474]
4-(2-(4-fluorobenzyloxy)phenyl)piperidine Drug Info [530474]
4-(2-(4-fluorophenoxy)phenyl)piperidine Drug Info [530474]
4-(2-(benzyloxy)-3-fluorophenyl)piperidine Drug Info [530474]
4-(2-(benzyloxy)-6-fluorophenyl)piperidine Drug Info [530474]
4-(2-(benzyloxy)phenyl)piperidine Drug Info [530474]
4-(2-fluoro-6-(2-fluorophenoxy)phenyl)piperidine Drug Info [530596]
4-(2-fluoro-6-(3-fluorophenoxy)phenyl)piperidine Drug Info [530474]
4-(2-fluoro-6-(4-fluorophenoxy)phenyl)piperidine Drug Info [530474]
4-(2-fluoro-6-phenoxyphenyl)piperidine Drug Info [530474]
4-(2-phenoxyphenyl)piperidine Drug Info [530474]
4-(3-fluoro-2-phenoxyphenyl)piperidine Drug Info [530474]
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one Drug Info [531079]
4-Benzyl-1-chroman-2-ylmethyl-piperidine Drug Info [527368]
4-Benzyl-1-chroman-3-ylmethyl-piperidine Drug Info [527368]
5,6-dichloro-3,4-dihydroquinazolin-2-amine Drug Info [529148]
5-chloro-3,4-dihydroquinazolin-2-amine Drug Info [529148]
5-chloro-4-ethyl-3,4-dihydroquinazolin-2-amine Drug Info [529148]
5-chloro-4-methyl-3,4-dihydroquinazolin-2-amine Drug Info [529148]
8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine Drug Info [551246]
8-Methoxy-2-(4-methyl-piperazin-1-yl)-quinoline Drug Info [533482]
8-Methoxy-2-piperazin-1-yl-quinoline Drug Info [533482]
8-methoxy-4-methyl-3,4-dihydroquinazolin-2-amine Drug Info [529148]
8-Methoxy-quinolin-2-ylamine Drug Info [533482]
9-Methoxy-1,2,3,4-tetrahydro-anthracen-2-ylamine Drug Info [551246]
A-80426 Drug Info [527799]
A-987306 Drug Info [529789]
AGROCLAVINE Drug Info [532683]
BMY-7378 Drug Info [534142]
Brolamfetamine Drug Info [533498]
CHLOROPHENYLPIPERAZINE Drug Info [533134]
CP-293019 Drug Info [534783]
ESCHOLTZINE Drug Info [528095]
Etisulergine Drug Info [533501]
JNJ-10392980 Drug Info [529569]
LYSERGIC ACID DIETHYLAMIDE Drug Info [533701]
MAZAPERTINE Drug Info [533800]
MCL-516 Drug Info [529541]
N-(3-(1H-indol-4-yloxy)propyl)cyclohexanamine Drug Info [529018]
N-(3-(1H-indol-4-yloxy)propyl)cyclopentanamine Drug Info [529018]
N-Benzyl-4-(2-diphenyl)-1-piperazinehexanamide Drug Info [529703]
N-methyllaurotetanine Drug Info [528095]
N-[4-(4-Phenyl-piperazin-1-yl)-butyl]-benzamide Drug Info [533428]
PB-28 Drug Info [534094]
PG-01037 Drug Info [528974]
PHENYLPIPERAZINE Drug Info [533482]
QUIPAZINE Drug Info [530451]
SB-271046 Drug Info [529191]
SB-656104 Drug Info [527395]
SEROTONIN Drug Info [530451]
SNAP-8719 Drug Info [527512]
SPIPERONE Drug Info [533936]
Sunepitron Drug Info [528210]
TERTATOLOL Drug Info [551246]
TIOSPIRONE Drug Info [528304]
UH-232 Drug Info [551330]
UH-301 Drug Info [534363]
WAY-466 Drug Info [527381]
WB-4101 Drug Info [533936]
Antagonist (R)-flurocarazolol Drug Info [526124]
(S)-flurocarazolol Drug Info [526124]
(S)-UH-301 Drug Info [538050]
(S)-WAY 100135 Drug Info [538050]
9-OH-risperidone Drug Info [534281]
AV-965 Drug Info [548414]
BINOSPIRONE MESYLATE Drug Info [526194], [551871]
cyamemazine Drug Info [526510]
DSP-1053 Drug Info [533288]
DU 125530 Drug Info [535456]
GR 125,743 Drug Info [534412]
GSK-958108 Drug Info [551853]
GSK163090 Drug Info [550963]
LECOZOTAN HYDROCHLORIDE Drug Info [528845], [551871]
LY433221 Drug Info [536286]
MIN-117 Drug Info [550002]
MPDT Drug Info [525722]
NAN-190 Drug Info [538050]
ORG-13011 Drug Info [525547], [551871]
P-MPPI Drug Info [538050], [538142]
p-[18F]MPPF Drug Info [527909]
PD-158771 Drug Info [536463]
REC-15/3079 Drug Info [526201]
repinotan Drug Info [534575]
Robalzotan Drug Info [535041]
RP5063 Drug Info [549962], [551645]
S-15535 Drug Info [525641], [551871]
SB 272183 Drug Info [526100]
SB 649915 Drug Info [527551]
SB 714786 Drug Info [527551]
SDZ 216-525 Drug Info [538050]
SLV-307 Drug Info [527204]
TGWOOAA Drug Info [550645]
Treximet Drug Info [550963]
Umespirone Drug Info [528329]
WAY 100135 Drug Info [538050]
WAY-100635 Drug Info [535073], [535298], [535456]
Xaliproden Drug Info [549823]
[11C]WAY100635 Drug Info [527424]
[3H]p-MPPF Drug Info [527360]
[3H]robalzotan Drug Info [534771]
[3H]WAY100635 Drug Info [534329]
Agonist 1-naphthylpiperazine Drug Info [534528]
1192U90 Drug Info [536463]
5-CT Drug Info [534412]
7-methoxy-1-naphthylpiperazine Drug Info [534528]
A-74283 Drug Info [534558]
Adatanserin Drug Info [534942], [536580]
ALNESPIRONE Drug Info [534835], [551871]
AP-521 Drug Info [533147], [551871]
BRL-15572 Drug Info [534475]
Buspirone Drug Info [536213]
CM-2236 Drug Info [550867]
CM-2395 Drug Info [548980]
CP 93129 Drug Info [534412]
Dual norepinephrine reuptake inhibitors/5-HT1A partial agonists Drug Info [543357]
Ebalzotan Drug Info [526199]
Eltoprazine Drug Info [551057]
EMDT Drug Info [525722]
Eptapirone Drug Info [527844]
FG-5893 Drug Info [534714]
Flesinoxan Drug Info [525612]
Gepirone ER Drug Info [536580]
GR-127607 Drug Info [545505]
Ipsapirone Drug Info [536988]
L-772,405 Drug Info [525646]
LESOPITRON DIHYDROCHLORIDE Drug Info [533618]
LP-12 Drug Info [528956]
LP-211 Drug Info [529703]
LP-44 Drug Info [528956]
LY 165,163 Drug Info [534714]
LY-293284 Drug Info [533615]
MN-305 Drug Info [536580]
nafadotride Drug Info [534714]
Nerisopam Drug Info [534238]
Neu-P11 Drug Info [551415]
piribedil Drug Info [526443]
S-14671 Drug Info [534606]
SB 216641 Drug Info [534475]
spiroxatrine Drug Info [534714]
SUN N4057 Drug Info [535277]
SUN-8399 Drug Info [533869]
U-93385 Drug Info [533820], [551871]
U92016A Drug Info [533822]
Urapidil Drug Info [538139]
Zalospirone Drug Info [533189]
[3H]8-OH-DPAT Drug Info [525927]
[3H]NLX-112 Drug Info [531129]
[3H]S-15535 Drug Info [534606]
Modulator Anpirtoline Drug Info [528148]
Bifeprunox Drug Info
BMS-181100 Drug Info
CGS-18102A Drug Info [526784]
CGS-19480A Drug Info [550159], [551871]
Du-123015 Drug Info [550367]
DU-29894 Drug Info [533724]
E2101 Drug Info [535482]
EMD 56551 Drug Info
Ensaculin hydrochloride Drug Info [526403]
Flibanserin Drug Info [532651]
HT-90B Drug Info [534198]
Mazapertine succinate Drug Info
NLX-101 Drug Info
NPT-500 Drug Info [543357]
OPC-14523 Drug Info [552279]
OPC-34712 Drug Info
PRX-00023 Drug Info
RWJ-25730 Drug Info
S-14506 Drug Info
S-16924 Drug Info [525424], [534704]
Sarizotan Drug Info
SDZ-MAR-327 Drug Info
SEL-73 Drug Info [543357]
SKL-PSY Drug Info [543357]
SLV-313 Drug Info
SR-59026 Drug Info
SSR-181507 Drug Info
TGBA01AD Drug Info
TGFK08AA-ER Drug Info [525395]
TGFK09SD-ER Drug Info [549115]
Trazodone Drug Info [556264]
Vilazodone Drug Info [531783]
Binder BTS-79018 Drug Info [536463]
Modulator (allosteric modulator) RS-30199 Drug Info [534687]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
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Ref 547174Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013610)
Ref 547248Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014469)
Ref 548413Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025412)
Ref 548510Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026154)
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