Drug General Information
Drug ID	D01YBD
Former ID	DNC012799
Drug Name	2-(4-Methyl-piperazin-1-yl)-4-phenyl-pyrimidine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[551319]
Structure		Download 2D MOL 3D MOL
Formula	C15H18N4
Canonical SMILES	CN1CCN(CC1)C2=NC=CC(=N2)C3=CC=CC=C3
InChI	1S/C15H18N4/c1-18-9-11-19(12-10-18)15-16-8-7-14(17-15)13-5-3-2-4-6-13/h2-8H,9-12H2,1H3
InChIKey	QHOBPFOGFURKFZ-UHFFFAOYSA-N
PubChem Compound ID	10332554
Target and Pathway
Target(s)	5-hydroxytryptamine 2A receptor	Target Info	Inhibitor	[551319]
	5-hydroxytryptamine 1A receptor	Target Info	Inhibitor	[551319]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
PANTHER Pathway	5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (i) signalling events
WikiPathways	Serotonin Receptor 2 and STAT3 Signaling
	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	SIDS Susceptibility Pathways
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
References
Ref 551319	4-(3-furyl)-2-(4-methylpiperazino)pyrimidines: Potent 5-HT2A receptor antagonists, Bioorg. Med. Chem. Lett. 7(13):1635-1638 (1997).
Ref 551319	4-(3-furyl)-2-(4-methylpiperazino)pyrimidines: Potent 5-HT2A receptor antagonists, Bioorg. Med. Chem. Lett. 7(13):1635-1638 (1997).

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