Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Cathepsin K --- MEP | {1-[4-(2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-3-oxo-azepane-1-carbonyl]-3-methyl-butyl}-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | CHEMBL563471 | Drug Info |
| Cathepsin K --- MEP | (S)-N-(3-(3-(1,3,4-oxadiazol-2-yl)phenyl)-1-(cyanomethylamino)-1-oxopropan-2-yl)benzamide | Drug Info |
| Cathepsin K --- MEP | N-(3-methyl-1-(4-(trifluoromethoxy)phenylamino)butan-2-yl)-4-morpholino-4-oxo-2-phenethylbutanamide | Drug Info |
| Cathepsin K --- MEP | 6-(4-chlorobenzyl)-7-neopentyl-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | Drug Info |
| Cathepsin K --- MEP | Naphthalene-1-carboxylic acid{3-methyl-1-[(S)-(S)-3-oxo-1-(pyridine-2-sulfonyl)-azepan-4-ylcarbamoyl]-butyl}-amide | Drug Info |
| Cathepsin K --- MEP | N-((S)-1-((2R,3R)-3-(benzyloxy)-1-(5-fluoroindolin-1-yl)butan-2-ylamino)-4-cyclohexyl-1-oxobutan-2-yl)-3-methoxybenzamide | Drug Info |
| Cathepsin K --- MEP | 6-[4-(4-Acetyl-piperazin-1-yl)-phenoxymethyl]-7-(2-cyclopentyl-ethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | Drug Info |
| Cathepsin K --- MEP | 5-Chloro-benzofuran-2-carboxylic acid {(S)-2-cyclohexyl-1-[2-(4-methoxy-phenylamino)-ethylcarbamoyl]-ethyl}-amide | Drug Info |
| Cathepsin K --- MEP | 2-[3-(1H-Indol-6-yl)-phenyl]-4-methyl-pentanoic acid cyanomethyl-amide | Drug Info |
| Cathepsin K --- MEP | N-[1-(2S-Ethyl-4-oxo-tetrahydro-furan-3S-ylcarbamoyl)-2S-(1-methyl-cyclopentyl)-ethyl]-4-(2-fluoro-benzenesulfonylamino)-benzamide | Drug Info |
| Cathepsin K --- MEP | {(S)-1-[2-(4-Cyclohexyloxy-phenylamino)-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | ((S)-3-Methyl-1-{2-[4-(tetrahydro-pyran-4-yloxy)-phenylamino]-ethylcarbamoyl}-butyl)-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | N-((S)-4-cyclohexyl-1-((2R,3R)-1-(5-fluoroindolin-1-yl)-3-hydroxybutan-2-ylamino)-1-oxobutan-2-yl)-3-methoxybenzamide | Drug Info |
| Cathepsin K --- MEP | 2-Cyano-4-[(spiro[2.5]oct-6-ylmethyl)-amino]-pyrimidine-5-carboxylic acid (4-benzyl-1-methyl-piperidin-4-yl)-amide | Drug Info |
| Cathepsin K --- MEP | 2-cyano-4-(2,2-dimethyl-propylamino)-pyrimidine-5-carboxylic acid {2-[3-(4-methyl-piperazin-1-yl)-phenyl]-ethyl}-amide | Drug Info |
| Cathepsin K --- MEP | [1-(3-Methoxy-1-methyl-2-oxo-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | N-{(S)-1-[2-(4-Methoxy-phenylamino)-ethylcarbamoyl]-2-phenyl-ethyl}-3-methyl-benzamide | Drug Info |
| Cathepsin K --- MEP | (S)-3-methyl-N-(4-methyl-1-oxo-1-(2-(4-(trifluoromethoxy)phenylamino)ethylamino)pentan-2-yl)benzamide | Drug Info |
| Cathepsin K --- MEP | 1-benzylcyclopentyl(S)-1,2-dioxo-1-((R)-1-phenylethylamino)heptan-3-ylcarbamate | Drug Info |
| Cathepsin K --- MEP | 4-(2-Cyano-benzenesulfonylamino)-N-[1-(2S-ethyl-4-oxo-tetrahydro-furan-3S-ylcarbamoyl)-2S-(1-methyl-cyclopentyl)-ethyl]-benzamide | Drug Info |
| Cathepsin K --- MEP | (S)-N-((R)-2-(benzyloxy)-1-cyanoethyl)-4-methyl-2-(2-(2-methyl-1H-imidazol-1-yl)acetamido)pentanamide | Drug Info |
| Cathepsin K --- MEP | 5-(3-(4-(4-methylpiperazin-1-yl)phenyl)prop-1-ynyl)-4-(neopentylamino)pyrimidine-2-carbonitrile | Drug Info |
| Cathepsin K --- MEP | 7-(2-cyclohexylethyl)-6-((pyridin-2-yloxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | Drug Info |
| Cathepsin K --- MEP | [(S)-5-[(Morpholine-4-carbonyl)-amino]-1-((R)-1-phenyl-ethylaminooxalyl)-pentyl]-carbamic acid 1-(4-fluoro-benzyl)-cyclobutylmethyl ester | Drug Info |
| Cathepsin K --- MEP | 4-Methyl-2-(4'-morpholin-2-yl-biphenyl-3-yl)-pentanoic acid cyanomethyl-amide | Drug Info |
| Cathepsin K --- MEP | 4-Methyl-2-(3-pyridin-4-yl-phenyl)-pentanoic acid cyanomethyl-(2,2,2-trifluoro-acetoxy)-amide | Drug Info |
| Cathepsin K --- MEP | (S)-3-tert-butyl-N-(1-(cyanomethylamino)-3-(3-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-1-oxopropan-2-yl)-1-methyl-1H-pyrazole-5-carboxamide | Drug Info |
| Cathepsin K --- MEP | N-((S)-4-methyl-1-((4S,7R)-7-methyl-3-oxo-1-picolinoylazepan-4-ylamino)-1-oxopentan-2-yl)furan-2-carboxamide | Drug Info |
| Cathepsin K --- MEP | N-((S)-1-((4S,7R)-7-methyl-3-oxo-1-(pyridin-2-ylsulfonyl)azepan-4-ylamino)-3-(4-methylcyclohexyl)-1-oxopropan-2-yl)furan-2-carboxamide | Drug Info |
| Cathepsin K --- MEP | 9-Cyclopentyl-6-(2-{4-[2-(2-methoxy-ethylamino)-ethoxy]-benzyloxy}-phenylamino)-9H-purine-2-carbonitrile | Drug Info |
| Cathepsin K --- MEP | N-{4-[5-(2-Thienyl)-1,2,4-oxadiazol-3-yl]benzoyl}-leucyl-glycine-nitrile | Drug Info |
| Cathepsin K --- MEP | N-((S)-1-((4S,7R)-7-methyl-3-oxo-1-(pyridin-2-ylsulfonyl)azepan-4-ylamino)-3-(1-methylcyclohexyl)-1-oxopropan-2-yl)furan-2-carboxamide | Drug Info |
| Cathepsin K --- MEP | [1-(3-Methoxy-1-methyl-2-oxo-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | 2-(cyclohexylmethyl)-4-morpholino-4-oxo-N-(1-(4-(trifluoromethoxy)phenylamino)propan-2-yl)butanamide | Drug Info |
| Cathepsin K --- MEP | 2-cyano-4-cyclohexylamino-pyrimidine-5-carboxylic acid [2-(3-methoxyphenyl)-ethyl]-amide | Drug Info |
| Cathepsin K --- MEP | 2-cyano-4-(2,2-dimethyl-propylamino)-pyrimidine-5-carboxylic acid [2-(3-methoxy-phenyl)-ethyl]-amide | Drug Info |
| Cathepsin K --- MEP | N-(tert-butoxycarbonyl)-phenylalanyl-glycine-nitrile | Drug Info |
| Cathepsin K --- MEP | N-[1-(2S-Ethyl-4-oxo-tetrahydro-furan-3S-ylcarbamoyl)-2S-(1-methyl-cyclopentyl)-ethyl]-3-fluoro-4-methanesulfonylamino-benzamide | Drug Info |
| Cathepsin K --- MEP | N-((S)-1-((2S,3S)-2-ethyl-4-oxotetrahydrofuran-3-ylamino)-4,4-dimethyl-1-oxopentan-2-yl)thiophene-3-carboxamide | Drug Info |
| Cathepsin K --- MEP | N-Cyanomethyl-2-[4'-(4-methyl-piperazin-1-yl)-biphenyl-3-yl]-3-phenyl-propionamide | Drug Info |
| Cathepsin K --- MEP | N-((S)-1-((R)-2-(benzyloxy)-1-cyanoethylamino)-4-methyl-1-oxopentan-2-yl)-1H-indole-2-carboxamide | Drug Info |
| Cathepsin K --- MEP | 6-(4-chlorobenzyl)-7-(2-cyclohexylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | Drug Info |
| Cathepsin K --- MEP | (S)-N-(cyanomethyl)-4-methyl-2-((S)-2,2,2-trifluoro-1-phenylethylamino)pentanamide | Drug Info |
| Cathepsin K --- MEP | [(S)-1-((2S,3S)-2-Isobutoxy-4-oxo-azetidin-3-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | 4-Benzenesulfonylamino-N-[1-(2S-ethyl-4-oxo-tetrahydro-furan-3S-ylcarbamoyl)-2S-(1-methyl-cyclopentyl)-ethyl]-3-methyl-benzamide | Drug Info |
| Cathepsin K --- MEP | 2-cyano-4-cyclohexylamino-pyrimidine-5-carboxylic acid [2-(4-methoxyphenyl)-ethyl]-amide | Drug Info |
| Cathepsin K --- MEP | (S)-N-((R)-2-(benzyloxy)-1-cyanoethyl)-4-methyl-2-(2-(4-(pyridin-4-yl)piperazin-1-yl)acetamido)pentanamide | Drug Info |
| Cathepsin K --- MEP | ((R)-1-Formyl-pentyl)-carbamic acid tert-butyl ester | Drug Info |
| Cathepsin K --- MEP | (S)-benzyl 1-(2-(4-methoxyphenylamino)ethylamino)-4-methyl-1-oxopentan-2-ylcarbamate | Drug Info |
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