Target Information
Target General Infomation | |||||
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Target ID |
T28265
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Former ID |
TTDS00285
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Target Name |
Alpha-1-antitrypsin
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Gene Name |
SERPINA1
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Synonyms |
Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Alpha1-proteinase; PRO0684/PRO2209; SERPINA1
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Target Type |
Successful
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Disease | Alpha-1 antitrypsin deficiency [ICD9: 273.4; ICD10: E88.0] | ||||
Chronic obstructive pulmonary disease; Cystic fibrosis [ICD9: 277.0, 460-519, 490-492, 494-496, 709.2; ICD10: E84, J00-J99, J40-J44, J47, L90.5] | |||||
Emphysema [ICD9: 492; ICD10: J43] | |||||
Unspecified [ICD code not available] | |||||
Function |
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin.
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BioChemical Class |
Serpin family
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UniProt ID | |||||
Sequence |
MPSSVSWGILLLAGLCCLVPVSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFS
LYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGF QELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQ INDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTV KVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFL ENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKA VLTIDEKGTEAAGAMFLEAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPTQK |
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Drugs and Mode of Action | |||||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
KEGG Pathway | Complement and coagulation cascades | ||||
NetPath Pathway | IL6 Signaling Pathway | ||||
PANTHER Pathway | Blood coagulation | ||||
Pathway Interaction Database | p73 transcription factor network | ||||
FOXA1 transcription factor network | |||||
Reactome | Platelet degranulation | ||||
COPII (Coat Protein 2) Mediated Vesicle Transport | |||||
Cargo concentration in the ER | |||||
WikiPathways | Complement and Coagulation Cascades | ||||
NRF2 pathway | |||||
Nuclear Receptors Meta-Pathway | |||||
References |
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