Drug Information

Drug General Information
Drug ID
D08ORM
Former ID
DNC009070
Drug Name
Ac-VEID-CHO
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543195]
Structure
Download
2D MOL

3D MOL
Formula
C22H36N4O9
InChI
InChI=1S/C22H36N4O9/c1-6-12(4)19(22(35)24-14(10-27)9-17(31)32)26-20(33)15(7-8-16(29)30)25-21(34)18(11(2)3)23-13(5)28/h10-12,14-15,18-19H,6-9H2,1-5H3,(H,23,28)(H,24,35)(H,25,34)(H,26,33)(H,29,30)(H,31,32)/t12-,14-,15-,18-,19-/m0/s1
InChIKey
KYUFGGNCJRWMDN-GOYXDOSHSA-N
PubChem Compound ID
15487887
PubChem Substance ID
80955681, 103632396, 131343484, 134346275, 135631496, 137275725, 162089020, 252166767
Target and Pathway
Target(s) mRNA of human caspase 6 Target Info Inhibitor [530042]
KEGG Pathway Apoptosis
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Direct p53 effectors
p75(NTR)-mediated signaling
C-MYB transcription factor network
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Caspase Cascade in Apoptosis
Reactome Apoptotic cleavage of cellular proteins
Caspase-mediated cleavage of cytoskeletal proteins
WikiPathways Apoptosis Modulation by HSP70
FAS pathway and Stress induction of HSP regulation
Apoptosis
Parkinsons Disease Pathway
Apoptotic execution phase
Apoptosis Modulation and Signaling
References
Ref 543195(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8566).
Ref 530042J Med Chem. 2009 Apr 23;52(8):2188-91.Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.