Drug Information

Drug General Information
Drug ID
D0R2ZN
Former ID
DNC011368
Drug Name
GNF-PF-826
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531262]
Structure
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2D MOL

3D MOL
Formula
C20H14N2O4S2
Canonical SMILES
C1=CC=C2C(=C1)C(=NS(=O)(=O)C3=CC=CS3)C=C(C2=O)NC4=CC=C(<br />C=C4)O
InChI
1S/C20H14N2O4S2/c23-14-9-7-13(8-10-14)21-18-12-17(15-4-1-2-5-16(15)20(18)24)22-28(25,26)19-6-3-11-27-19/h1-12,21,23H
InChIKey
YXKCWSSSTBYFQS-UHFFFAOYSA-N
PubChem Compound ID
2391700
Target and Pathway
Target(s) Sphingosine 1-phosphate receptor 1 Target Info Inhibitor [531262]
Nuclear receptor coactivator 3 Target Info Inhibitor [531262]
KEGG Pathway FoxO signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interactionhsa04919:Thyroid hormone signaling pathway
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
IL2 Signaling PathwayNetPath_16:IL4 Signaling Pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
S1P3 pathway
S1P1 pathway
Sphingosine 1-phosphate (S1P) pathway
PDGFR-beta signaling pathwayerb_genomic_pathway:Validated nuclear estrogen receptor beta network
Validated nuclear estrogen receptor alpha network
Retinoic acid receptors-mediated signaling
FOXA1 transcription factor network
Reactome G alpha (i) signalling events
Lysosphingolipid and LPA receptorsR-HSA-1989781:PPARA activates gene expression
Transcriptional regulation of white adipocyte differentiation
MAPK6/MAPK4 signaling
WikiPathways Signal Transduction of S1P Receptor
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP710:DNA Damage Response (only ATM dependent)
EGF/EGFR Signaling Pathway
Nuclear Receptors Meta-Pathway
Pregnane X Receptor pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Transcriptional Regulation of White Adipocyte Differentiation
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
Integrated Breast Cancer Pathway
Androgen receptor signaling pathway
References
Ref 531262Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).
Ref 531262Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).

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