Drug Information

Drug General Information
Drug ID
D0U1MN
Former ID
DNC011842
Drug Name
1-Ethyl-4-(2-methoxy-phenyl)-piperazine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533873]
Structure
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2D MOL

3D MOL
Formula
C13H20N2O
Canonical SMILES
CCN1CCN(CC1)C2=CC=CC=C2OC
InChI
1S/C13H20N2O/c1-3-14-8-10-15(11-9-14)12-6-4-5-7-13(12)16-2/h4-7H,3,8-11H2,1-2H3
InChIKey
VLKJSRWSKNCNBI-UHFFFAOYSA-N
PubChem Compound ID
10376185
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Inhibitor [533873]
5-hydroxytryptamine 2A receptor Target Info Inhibitor [533873]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04020:Calcium signaling pathway
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
GPCRs, Other
References
Ref 533873J Med Chem. 1994 Aug 19;37(17):2754-60.Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
Ref 533873J Med Chem. 1994 Aug 19;37(17):2754-60.Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.

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