Drug Information

Drug General Information
Drug ID
D0GB0P
Former ID
DAP000610
Drug Name
Amrinone
Synonyms
Amcoral; Amrinon; Amrinona; Amrinonum; Cartonic; Cordemcura; Inamrinone; Inocor; Wincoram; Inamrinone lactate; WIN40680; AWD 08-250; Amcoral (TN); Amrinona [INN-Spanish]; Amrinonum [INN-Latin]; Inamrinone (USP); Inocor (TN); Win-40680; Amrinone (JAN/INN); Inamrinone [USAN:BAN:INN]; 3-Amino-5-(4-pyridinyl)-2(1H)-pyridinone; 3-amino-5-pyridin-4-yl-1H-pyridin-2-one; 5-Amino(3,4'-bipyridin)-6(1H)-one; 5-Amino-(3,4'-bipyridin)-6(1H)-one; 5-Amino-(3,4'-bipyridine)-6(1H)-one; 5-amino-3,4'-bipyridin-6(1H)-one
Drug Type
Small molecular drug
Indication Congestive heart failure [ICD9: 428; ICD10:I50] Approved [536361], [551871]
Therapeutic Class
Cardiotonic Agents
Formula
C10H9N3O
Canonical SMILES
C1=CN=CC=C1C2=CNC(=O)C(=C2)N
InChI
1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)
InChIKey
RNLQIBCLLYYYFJ-UHFFFAOYSA-N
CAS Number
CAS 60719-84-8
PubChem Compound ID
3698
PubChem Substance ID
7548659, 7847298, 7978481, 8149898, 8152337, 10321145, 11112811, 11335311, 11360550, 11364244, 11366806, 11369368, 11372151, 11374536, 11377530, 11461522, 11466828, 11467948, 11485875, 11486615, 11489796, 11490771, 11492883, 11495164, 11533005, 12013242, 15322199, 24890741, 26612393, 26679439, 26750001, 26757798, 29222821, 46504647, 47588851, 47588852, 47662121, 47736320, 47736321, 48334342, 48415563, 49698646, 49894593, 56424028, 57321946, 72294019, 76717395, 81093311, 85174435, 85788972
SuperDrug ATC ID
C01CE01
SuperDrug CAS ID
cas=060719848
Target and Pathway
Target(s) CGMP-inhibited 3',5'-cyclic phosphodiesterase Target Info Inhibitor [535488]
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535488Effects of amrinone on hepatic ischemia-reperfusion injury in rats. J Hepatol. 2002 Jul;37(1):31-8.

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