Target Information

Target General Infomation
Target ID
T03644
Former ID
TTDI02186
Target Name
Alpha-synuclein
Gene Name
SNCA
Synonyms
NACP; NonA beta component of AD amyloid; NonA4 component of amyloid precursor; SNCA
Target Type
Clinical Trial
Disease Alzheimer disease [ICD9: 331; ICD10: G30]
Parkinson's disease [ICD9: 332; ICD10: G20]
Function
May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
BioChemical Class
Synuclein family
UniProt ID
P37840
Sequence
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK
EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP
DNEAYEMPSEEGYQDYEPEA
Drugs and Mode of Action
Drug(s) Posiphen R-phenserine Drug Info Phase 1 Alzheimer disease [550986]
RG7935 Drug Info Phase 1 Parkinson's disease [549547]
Modulator Posiphen R-phenserine Drug Info [550986], [550987]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Alzheimer&#039
s disease
Parkinson&#039
NetPath Pathway Leptin Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Parkinson disease
Pathway Interaction Database Alpha-synuclein signaling
Reactome Amyloid formation
WikiPathways Ectoderm Differentiation
Parkinsons Disease Pathway
Parkin-Ubiquitin Proteasomal System pathway
Alzheimers Disease
References
Ref 549547Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800040327)
Ref 550986The Anticholinesterase Phenserine and Its Enantiomer Posiphen as 5??ntranslated-Region-Directed Translation Blockers of the Parkinson's Alpha Synuclein Expression. Parkinson's Disease Volume 2012 (2012), Article ID 142372, Page(13).
Ref 544219alpha-Synuclein in Parkinson's Disease. Cold Spring Harb Perspect Med. 2012 February; 2(2): a009399.
Ref 550986The Anticholinesterase Phenserine and Its Enantiomer Posiphen as 5??ntranslated-Region-Directed Translation Blockers of the Parkinson's Alpha Synuclein Expression. Parkinson's Disease Volume 2012 (2012), Article ID 142372, Page(13).
Ref 550987The Anticholinesterase Phenserine and Its Enantiomer Posiphen as 5??ntranslated-Region-Directed Translation Blockers of the Parkinson's Alpha Synuclein Expression. Parkinson's Disease Volume 2012 (2012), Article ID 142372, Page(13).

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