Target Information
Target General Infomation | |||||
---|---|---|---|---|---|
Target ID |
T09092
|
||||
Former ID |
TTDR00138
|
||||
Target Name |
Interleukin-10
|
||||
Gene Name |
IL10
|
||||
Synonyms |
CSIF; Cytokine synthesis inhibitory factor; IL-10; IL10
|
||||
Target Type |
Clinical Trial
|
||||
Disease | Endometriosis [ICD9: 617; ICD10: N80] | ||||
Inflammatory bowel disease; Psoriasis; Rheumatoid arthritis [ICD9: 555, 556, 696, 710-719, 714; ICD10: K50, K51, L40, M00-M25, M05-M06] | |||||
Solid tumours [ICD9: 140-199, 210-229; ICD10: C00-D48] | |||||
Scar tissue [ICD10: L00-L99] | |||||
Function |
Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.
|
||||
BioChemical Class |
Cytokine: interleukin
|
||||
UniProt ID | |||||
Sequence |
MHSSALLCCLVLLTGVRASPGQGTQSENSCTHFPGNLPNMLRDLRDAFSRVKTFFQMKDQ
LDNLLLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENQDPDIKAHVNSLGENLKTLR LRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGIYKAMSEFDIFINYIEAYMTMKIRN |
||||
Drugs and Mode of Action | |||||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
KEGG Pathway | Cytokine-cytokine receptor interaction | ||||
FoxO signaling pathway | |||||
Jak-STAT signaling pathway | |||||
T cell receptor signaling pathway | |||||
Intestinal immune network for IgA production | |||||
Pertussis | |||||
Leishmaniasis | |||||
Chagas disease (American trypanosomiasis) | |||||
African trypanosomiasis | |||||
Malaria | |||||
Toxoplasmosis | |||||
Amoebiasis | |||||
Staphylococcus aureus infection | |||||
Tuberculosis | |||||
Epstein-Barr virus infection | |||||
Asthma | |||||
Autoimmune thyroid disease | |||||
Inflammatory bowel disease (IBD) | |||||
Systemic lupus erythematosus | |||||
Allograft rejection | |||||
NetPath Pathway | TCR Signaling Pathway | ||||
BCR Signaling Pathway | |||||
IL2 Signaling Pathway | |||||
IL4 Signaling Pathway | |||||
PANTHER Pathway | Interleukin signaling pathway | ||||
Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | ||||
IL4-mediated signaling events | |||||
AP-1 transcription factor network | |||||
WikiPathways | SIDS Susceptibility Pathways | ||||
Cytokines and Inflammatory Response | |||||
Allograft Rejection | |||||
References | |||||
Ref 522798 | ClinicalTrials.gov (NCT00984646) Investigation Into the Scar Reduction Potential of Prevascar (Interleukin-10). U.S. National Institutes of Health. | ||||
Ref 530407 | Preclinical characterization of DEKAVIL (F8-IL10), a novel clinical-stage immunocytokine which inhibits the progression of collagen-induced arthritis. Arthritis Res Ther. 2009;11(5):R142. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.