Target Information

Target General Infomation
Target ID
T83875
Former ID
TTDS00289
Target Name
Amine oxidase [flavin-containing] A
Gene Name
MAOA
Synonyms
MAO-A; Monoamine oxidase; Monoamine oxidase A; MAOA
Target Type
Successful
Disease Anxiety disorder [ICD9: 300, 311; ICD10: F32, F40-F42]
Alzheimer disease [ICD9: 331; ICD10: G30]
Alcohol use disorders [ICD9: 303; ICD10: F10.2]
Depression [ICD9: 311; ICD10: F30-F39]
Epilepsy [ICD10: G40]
Major depressive episode without melancholia [ICD10: F30-F39]
Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10: F32, F33, M32]
Mood disorder [ICD10: F30-F39]
Neuropathic pain [ICD9: 356.0, 356.8; ICD10: G64, G90.0]
Parkinson's disease; Major depressive disorder [ICD9:332, 296.2, 296.3, 710.0; ICD10: G20, F32, F33, M32]
Vitiligo [ICD9: 709.01; ICD10: L80]
Function
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
BioChemical Class
Oxidoreductases acting on CH-NH2 group of donors
Target Validation
T83875
UniProt ID
P21397
EC Number
EC 1.4.3.4
Sequence
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHV
DYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIA
YLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNI
NVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKL
NHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPM
GAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADR
LAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG
RVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKD
VPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
Drugs and Mode of Action
Drug(s) Clorgyline Drug Info Approved Parkinson's disease; Major depressive disorder [1], [2], [3]
Isocarboxazid Drug Info Approved Depression [4], [5]
Moclobemide Drug Info Approved Depression [6], [7]
Tranylcypromine Drug Info Approved Major depressive episode without melancholia [3]
Psoralen Drug Info Phase 3 Discovery agent [8]
TRYPTAMINE Drug Info Phase 3 Discovery agent [9], [10]
CHF-3381 Drug Info Phase 2 Neuropathic pain [11], [12]
CX157 Drug Info Phase 2 Mood disorder [13]
Ladostigil Drug Info Phase 2 Alzheimer disease [14]
PIPERINE Drug Info Phase 1/2 Vitiligo [15], [16]
Desoxypeganine Drug Info Phase 1 Alcohol use disorders [17]
Befloxatone Drug Info Discontinued in Phase 3 Major depressive disorder [18], [19]
Brofaromine Drug Info Discontinued in Phase 2 Anxiety disorder [20]
CS-722 Drug Info Discontinued in Phase 2 Epilepsy [21]
ESUPRONE Drug Info Discontinued in Phase 2 Major depressive disorder [22]
RS-8359 Drug Info Discontinued in Phase 2 Major depressive disorder [23]
BW-1370U87 Drug Info Discontinued in Phase 1 Major depressive disorder [24]
Bifemelane Drug Info Terminated Alzheimer disease [25]
E-2011 Drug Info Terminated Anxiety disorder [26]
Inhibitor (+/-)-2-(4'-Benzyloxyphenyl)thiomorpholine Drug Info [27]
(+/-)-2-(4'-Butoxyphenyl)thiomorpholin-5-one Drug Info [27]
(+/-)-2-(4'-Butoxyphenyl)thiomorpholine Drug Info [27]
(+/-)-2-(4'-Ethoxyphenyl)thiomorpholin-5-one Drug Info [27]
(+/-)-2-(4'-Ethoxyphenyl)thiomorpholine Drug Info [27]
(+/-)-2-(4'-Methoxyphenyl)thiomorpholin-5-one Drug Info [27]
(+/-)-2-(4'-Methoxyphenyl)thiomorpholine Drug Info [27]
(+/-)-2-(4'-Propoxyphenyl)thiomorpholin-5-one Drug Info [27]
(+/-)-2-(4'-Propoxyphenyl)thiomorpholine Drug Info [27]
(+/-)-2-Phenylthiomorpholin-5-one Drug Info [27]
(+/-)-2-Phenylthiomorpholine Drug Info [27]
(6-Benzyloxy-2-naphthyl)-2-aminopropane Drug Info [28]
(6-Butoxy-2-naphthyl)-2-aminopropane Drug Info [28]
(6-Ethoxy-2-naphthyl)-2-aminopropane Drug Info [28]
(6-Methoxy-2-naphthyl)-2-aminopropane Drug Info [28]
(6-methylthio-2-naphthyl)isopropylamine Drug Info [28]
(6-Propoxy-2-naphthyl)-2-aminopropane Drug Info [28]
(7-Benzyloxy-2-oxo-2H-chromen-4-yl)acetonitrile Drug Info [29]
(E)-5-(3-Chlorostyryl)isatin Drug Info [30]
(E)-5-(3-Fluorostyryl)isatin Drug Info [30]
(E)-5-Styrylisatin Drug Info [30]
(R)-Indan-1-yl-methyl-prop-2-ynyl-amine Drug Info [31]
(R,S)-N-(R-phenylethyl)-1H-pyrrole-2-carboxamide Drug Info [32]
(R/R)BEFLOXATONE Drug Info [33]
(S)-2-amino-1-(4-butylthiophenyl)-propane Drug Info [34]
(S)-2-amino-1-(4-ethylthiophenyl)-propane Drug Info [34]
(S)-2-amino-1-(4-methylthiophenyl)-propane Drug Info [34]
(S)-2-amino-1-(4-propylthiophenyl)-propane Drug Info [34]
1,2,3,4-Tetrahydro-pyrazino[1,2-a]indole Drug Info [35]
1-(1-Naphthyl)-2-aminopropane Drug Info [28]
1-(2-Naphthyl)-2-aminopropane Drug Info [28]
1-(3-(4-chlorobenzyl)quinoxalin-2-yl)hydrazine Drug Info [36]
1-(3-benzyl-6,7-dichloroquinoxalin-2-yl)hydrazine Drug Info [36]
1-(3-benzylquinoxalin-2-yl)hydrazine Drug Info [36]
1-(4-(benzyloxy)phenyl)propan-2-amine Drug Info [28]
1-(4-butoxyphenyl)propan-2-amine Drug Info [28]
1-(4-ethoxyphenyl)propan-2-amine Drug Info [28]
1-(4-propoxyphenyl)propan-2-amine Drug Info [28]
2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indole Drug Info [37]
2-(2-cycloheptylidenehydrazinyl)-4-phenylthiazole Drug Info [38]
2-(2-cyclopentylidenehydrazinyl)-4-phenylthiazole Drug Info [38]
2-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-imidazole Drug Info [39]
2-(3-benzylquinoxalin-2-ylamino)ethanol Drug Info [36]
2-(4,5-dihydro-1H-imidazol-2-yl)quinoline Drug Info [39]
2-(4-methoxyphenyl)-4,5-dihydro-1H-imidazole Drug Info [39]
2-(5-phenyl-furan-2-yl)-4,5-dihydro-1H-imidazole Drug Info [40]
2-(naphthalen-2-yl)-4,5-dihydro-1H-imidazole Drug Info [39]
2-Amino-1-(4-methylthiophenyl)propane Drug Info [28]
2-BFi Drug Info [41]
2-Bromo-N-(2-morpholinoethyl)nicotinamide Drug Info [42]
2-Chloro-N-(2-morpholinoethyl)nicotinamide Drug Info [42]
2-Chloro-N-(3-morpholinopropyl)nicotinamide Drug Info [42]
2-Furan-2-yl-4,5-dihydro-1H-imidazole Drug Info [43]
2-oxo-N-m-tolyl-2H-chromene-3-carboxamide Drug Info [44]
2-oxo-N-p-tolyl-2H-chromene-3-carboxamide Drug Info [44]
2-oxo-N-phenyl-2H-chromene-3-carboxamide Drug Info [44]
2-Phenethyl-4,5-dihydro-1H-imidazole Drug Info [43]
2-Phenoxymethyl-4,5-dihydro-1H-imidazole Drug Info [43]
2-phenyl-5H-indeno[1,2-d]pyrimidine Drug Info [45]
2-phenyl-9H-indeno[2,1-d]pyrimidine Drug Info [45]
2-[7-(Benzyloxy)-2-oxo-2H-chromen-4-yl]acetamide Drug Info [29]
3,4-Benzo-7-(beta-bromoallyloxy)-8-methylcoumarin Drug Info [46]
3,4-Benzo-7-acetonyloxy-8-methoxycoumarin Drug Info [46]
3,4-Benzo-7-acetonyloxy-8-methylcoumarin Drug Info [46]
3,4-Dichloro-N-(2-methyl-1H-indol-5-yl)benzamide Drug Info [47]
3-aminoacetamido-4'-methylfuro[3,2-g]coumarin Drug Info [48]
3-benzyl-N-(2-morpholinoethyl)quinoxalin-2-amine Drug Info [36]
3-Chloro-N-(2-methyl-1H-indol-5-yl)benzamide Drug Info [47]
3-methyl-2(1H)-thioxo-4(3H)-quinazolinone Drug Info [49]
4,8-Dimethyl-7-(2'-oxocyclohexyloxy)coumarin Drug Info [46]
4,9-Dihydro-3H-beta-carboline Drug Info [35]
4-(2-oxo-2H-chromene-3-carboxamido)benzoic acid Drug Info [44]
4-(Aminomethyl)-7-(benzyloxy)-2H-chromen-2-one Drug Info [29]
4-Chloro-N-(2-morpholinoethyl)nicotinamide Drug Info [42]
4-Chloro-N-(3-morpholinopropyl)nicotinamide Drug Info [42]
4-methyl-2H-benzofuro[3,2-g]chromen-2-one Drug Info [48]
4-methyl-7-(2-oxocyclopentyloxy)-2H-chromen-2-one Drug Info [46]
5,6-Dichloro-N-(2-morpholinoethyl)nicotinamide Drug Info [42]
5,6-Dichloro-N-(3-morpholinopropyl)nicotinamide Drug Info [42]
5-Azidomethyl-3-pyrrol-1-yl-oxazolidin-2-one Drug Info [33]
5-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline Drug Info [37]
5-Bromo-4,9-dihydro-3H-beta-carboline Drug Info [37]
5-Hydroxymethyl-3-pyrrol-1-yl-oxazolidin-2-one Drug Info [33]
5-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline Drug Info [37]
5-Methoxy-4,9-dihydro-3H-beta-carboline Drug Info [37]
5-Methoxymethyl-3-pyrrol-1-yl-oxazolidin-2-one Drug Info [33]
6,11-dihydro-5H-benzo[a]carbazole Drug Info [45]
6-amino-9-methoxy-7H-furo[3,2-g]chromen-7-one Drug Info [46]
6-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline Drug Info [37]
6-Bromo-4,9-dihydro-3H-beta-carboline Drug Info [37]
6-Chloro-N-(2-morpholinoethyl)nicotinamide Drug Info [42]
6-Chloro-N-(3-morpholinopropyl)nicotinamide Drug Info [42]
6-Fluoro-N-(2-morpholinoethyl)nicotinamide Drug Info [42]
6-Hydroxy-N-(2-morpholinoethyl)nicotinamide Drug Info [42]
6-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline Drug Info [35]
6-Methoxy-4,9-dihydro-3H-beta-carboline Drug Info [35]
7-(3-chlorobenzyloxy)-4-carboxaldehyde-coumarin Drug Info [50]
7-Acetonyloxy-3,4-cyclohexene-8-methylcoumarin Drug Info [46]
7-Acetonyloxy-3,4-cyclopentene-8-methylcoumarin Drug Info [46]
7-acetonyloxy-3-acetylamino-8-methoxycoumarin Drug Info [48]
7-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline Drug Info [37]
7-Bromo-4,9-dihydro-3H-beta-carboline Drug Info [37]
7-METHOXY-1-METHYL-9H-BETA-CARBOLINE Drug Info [51]
7-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline Drug Info [43]
7-Methoxy-9H-beta-carboline Drug Info [37]
8-(3-Bromobenzyloxy)caffeine Drug Info [52]
8-(3-Chlorobenzyloxy)caffeine Drug Info [52]
8-(3-Fluorobenzyloxy)caffeine Drug Info [52]
8-(3-Methoxybenzyloxy)caffeine Drug Info [52]
8-(3-Methylbenzyloxy)caffeine Drug Info [52]
8-Benzyloxycaffeine Drug Info [52]
8-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline Drug Info [37]
8-Bromo-4,9-dihydro-3H-beta-carboline Drug Info [37]
8-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline Drug Info [37]
8-Methoxy-4,9-dihydro-3H-beta-carboline Drug Info [37]
8-[(3-Trifluoromethyl)benzyloxy]caffeine Drug Info [52]
9-(3-aminopropoxy)-7H-furo[3,2-g]chromen-7-one Drug Info [48]
9-Methyl-2,3,4,9-tetrahydro-1H-beta-carboline Drug Info [37]
Befloxatone Drug Info [53]
Beta-methoxyamphetamine Drug Info [28]
BW-1370U87 Drug Info [54], [3]
C-(1H-Indol-3-yl)-methylamine Drug Info [37]
CGS-19281A Drug Info [35]
CHF-3381 Drug Info [12]
Cis-(+/-)-2-Fluoro-1,2-diphenylcyclopropylamine Drug Info [55]
Cis-2-phenylcyclopropylamine Drug Info [55]
Clorgyline Drug Info [1]
CS-722 Drug Info [56]
CX157 Drug Info [57]
DECYL(DIMETHYL)PHOSPHINE OXIDE Drug Info [51]
ESUPRONE Drug Info [58], [3]
Ethyl 4-(2-oxo-2H-chromene-3-carboxamido)benzoate Drug Info [44]
FA-70 Drug Info [59]
Flavin-Adenine Dinucleotide Drug Info [60]
HARMINE Drug Info [61]
HYDRAZINECARBOXAMIDE Drug Info [62]
IPRONIAZIDE Drug Info [42]
Isocarboxazid Drug Info [63]
Isopsoralen Drug Info [64]
Ladostigil Drug Info [14]
Moclobemide Drug Info [65]
N'-(2-phenylallyl)hydrazine hydrochloride Drug Info [66]
N-((1H-indol-2-yl)methyl)(phenyl)methanamine Drug Info [67]
N-((1H-indol-2-yl)methyl)-2-phenylethanamine Drug Info [67]
N-(1-Methyl-1H-indol-2-ylmethyl)-N-phenylamine Drug Info [67]
N-(1H-Indol-2-ylmethyl)-N-(4-phenylbutyl)amine Drug Info [67]
N-(1H-Indol-2-ylmethyl)-N-methyl-N-phenylamine Drug Info [67]
N-(1H-Indol-2-ylmethyl)-N-phenylamine Drug Info [67]
N-(2-benzyl),N-(1-methylpyrrol-2-ylmethyl)amine Drug Info [32]
N-(2-Methyl-1H-indol-5-yl)cyclohexanecarboxamide Drug Info [47]
N-(2-phenylethyl),N-(pyrrol-2-ylmethyl)amine Drug Info [32]
N-(2-Phenylethyl)-1H-indole-2-carboxamide Drug Info [67]
N-(3-Phenylpropyl)-1H-indole-2-carboxamide Drug Info [67]
N-(3-phenylpropyl)-1H-pyrrole-2-carboxamide Drug Info [32]
N-(4-Ethylphenyl)-2-oxo-2H-chromene-3-carboxamide Drug Info [44]
N-(4-Phenylbutyl)-1H-indole-2-carboxamide Drug Info [67]
N-(4-phenylbutyl)-1H-pyrrole-2-carboxamide Drug Info [32]
N-(benzyl),N-(pyrrol-2-ylmethyl)amine Drug Info [32]
N-(propargyl),N-(pyrrol-2-ylmethyl)amine Drug Info [32]
N-2-phenylethyl-1H-pyrrole-2-carboxamide Drug Info [32]
N-Benzyl,N-methyl-1H-indole-2-carboxamide Drug Info [67]
N-benzyl,N-methyl-1H-pyrrole-2-carboxamide Drug Info [32]
N-Benzyl-(6-butoxy-2-naphthyl)-2-aminopropane Drug Info [28]
N-Benzyl-(6-methoxy-2-naphthyl)-2-aminopropane Drug Info [28]
N-Benzyl-1H-indole-2-carboxamide Drug Info [67]
N-benzyl-1H-pyrrole-2-carboxamide Drug Info [32]
N-Benzyl-N-(1H-indol-2-ylmethyl)-N-methylamine Drug Info [67]
N-methyl,N-(benzyl),N-(pyrrol-2-ylmethyl)amine Drug Info [32]
N-methyl,N-(propargyl),N-(pyrrol-2-ylmethyl)amine Drug Info [32]
N-Methyl,N-phenyl-1H-indole-2-carboxamide Drug Info [67]
N-methyl-N-(prop-2-ynyl)-1H-pyrrole-2-carboxamide Drug Info [32]
N-Phenyl-1-methyl-1H-indole-2-carboxamide Drug Info [67]
N-Phenyl-1H-indole-2-carboxamide Drug Info [67]
N-phenyl-1H-pyrrole-2-carboxamide Drug Info [32]
N-propargyl-1H-pyrrole-2-carboxamide Drug Info [32]
N2-[4-(benzyloxy)benzyl]glycinamide Drug Info [68]
N2-{4-[(3-fluorobenzyl)oxy]benzyl}glycinamide Drug Info [68]
N2-{4-[(4-chlorobenzyl)oxy]benzyl}glycinamide Drug Info [68]
NSC-656158 Drug Info [69]
Phenyl 4-(4,5-dihydro-1H-imidazol-2-yl)benzoate Drug Info [39]
PIPERINE Drug Info [61]
PNU-22394 Drug Info [37]
Psoralen Drug Info [64]
RS-8359 Drug Info [70]
TOLOXATONE Drug Info [71]
TRACIZOLINE Drug Info [43]
Trans-(+/-)-2-Fluoro-1,2-diphenylcyclopropylamine Drug Info [55]
Trans-2-(4-chlorophenyl)-2-fluorocyclopropanamine Drug Info [55]
Trans-2-fluoro-2-(4-fluorophenyl)cyclopropanamine Drug Info [55]
Trans-2-fluoro-2-p-tolylcyclopropanamine Drug Info [55]
Trans-2-fluoro-2-phenylcyclopropylamin Drug Info [55]
Tranylcypromine Drug Info [72], [73]
TRYPTAMINE Drug Info [37]
TRYPTOLINE Drug Info [43]
Antagonist 4-Methoxyamphetamine Drug Info [74]
MMDA Drug Info [60]
Modulator Bifemelane Drug Info [25]
Brofaromine Drug Info [75]
Desoxypeganine Drug Info [17]
E-2011 Drug Info [76]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
BioCyc Pathway Superpathway of tryptophan utilization
Dopamine degradation
Putrescine degradation III
Noradrenaline and adrenaline degradation
Serotonin degradation
Superpathway of melatonin degradation
Melatonin degradation II
KEGG Pathway Glycine, serine and threonine metabolism
Arginine and proline metabolism
Histidine metabolism
Tyrosine metabolism
Phenylalanine metabolism
Tryptophan metabolism
Drug metabolism - cytochrome P450
Metabolic pathways
Serotonergic synapse
Dopaminergic synapse
Cocaine addiction
Amphetamine addiction
Alcoholism
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
5-Hydroxytryptamine degredation
Dopamine receptor mediated signaling pathway
PathWhiz Pathway Histidine Metabolism
Tyrosine Metabolism
Glycine and Serine Metabolism
Reactome Norepinephrine Neurotransmitter Release Cycle
WikiPathways SIDS Susceptibility Pathways
Biogenic Amine Synthesis
Oxidative Stress
Dopamine metabolism
Phase 1 - Functionalization of compounds
Neurotransmitter Release Cycle
Neurotransmitter Clearance In The Synaptic Cleft
Serotonin Transporter Activity
References
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REF 2(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6636).
REF 3Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
REF 4FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 011961.
REF 5(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7204).
REF 6Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
REF 7(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7428).
REF 8ClinicalTrials.gov (NCT01686594) PUVA Maintenance Therapy in Mycosis Fungoides. U.S. National Institutes of Health.
REF 9ClinicalTrials.gov (NCT00227136) Effect of Oral 5-HTP Intake on Urinary 5-HIAA Excretion. U.S. National Institutes of Health.
REF 10(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 125).
REF 11Indantadol, a novel NMDA antagonist and nonselective MAO inhibitor for the potential treatment of neuropathic pain. IDrugs. 2007 Sep;10(9):636-44.
REF 12Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.
REF 13ClinicalTrials.gov (NCT01246908) Efficacy, Safety and Tolerability of CX157 in Treatment Resistant Depression. U.S. National Institutes of Health.
REF 14Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment. Curr Drug Targets. 2012 Apr;13(4):483-94.
REF 15ClinicalTrials.gov (NCT01383694) Effect Of Piperine In Patients With Oropharyngeal Dysphagia. U.S. National Institutes of Health.
REF 16(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2489).
REF 17Phase I clinical trial with desoxypeganine, a new cholinesterase and selective MAO-A inhibitor: tolerance and pharmacokinetics study of escalating single oral doses. Methods Find Exp Clin Pharmacol. 2008 Mar;30(2):141-7.
REF 18(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6637).
REF 19Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001426)
REF 20Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000689)
REF 21Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003060)
REF 22Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005281)
REF 23Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000633)
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REF 254-(O-benzylphenoxy)-N-methylbutylamine (bifemelane) and other 4-(O-benzylphenoxy)-N-methylalkylamines as new inhibitors of type A and B monoamine oxidase. J Neurochem. 1988 Jan;50(1):243-7.
REF 26Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002928)
REF 27Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. Epub 2010 Jan 15.2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors.
REF 28Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. Epub 2009 Feb 8.Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors.
REF 29J Med Chem. 2009 Nov 12;52(21):6685-706.Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B inhibitor.
REF 30Bioorg Med Chem Lett. 2009 May 1;19(9):2509-13. Epub 2009 Mar 14.Inhibition of monoamine oxidase by (E)-styrylisatin analogues.
REF 31J Med Chem. 2002 Nov 21;45(24):5260-79.Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease.
REF 32J Med Chem. 2007 Mar 8;50(5):922-31. Epub 2007 Jan 26.New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.
REF 33J Med Chem. 2002 Mar 14;45(6):1180-3.3-(1H-Pyrrol-1-yl)-2-oxazolidinones as reversible, highly potent, and selective inhibitors of monoamine oxidase type A.
REF 34Bioorg Med Chem. 2007 Aug 1;15(15):5198-206. Epub 2007 May 22.Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives: insights from molecular modeling studies.
REF 35Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5.Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands.
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