Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D0R9CH
|
|||
Former ID |
DNC007526
|
|||
Drug Name |
ZK-810388
|
|||
Synonyms |
3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[4,5-dihydro-1,3-oxazol-2-yl(methyl)amino]methyl}thiophene-2-carboxamide; 3-chloro-N-[4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl]-4-[[4,5-dihydro-1,3-oxazol-2-yl(methyl)amino]methyl]thiophene-2-carboxamide; AC1MOUJH; 1mq6; ZK-810388; Thiophene-Anthranilamide, 13a; CHEMBL173994; BDBM17111; ZK810388; ZK 810388; N-[2-(5-Chloro-2-pyridinylcarbamoyl)-4-chloro-6-methoxyphenyl]-3-chloro-4-(methyl 2-oxazoline-2-ylaminomethyl)thioph
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
|||
Formula |
C23H20Cl3N5O4S
|
|||
Canonical SMILES |
CN(CC1=CSC(=C1Cl)C(=O)NC2=C(C=C(C=C2OC)Cl)C(=O)NC3=NC=C(C=C3)Cl)C4=NCCO4
|
|||
InChI |
1S/C23H20Cl3N5O4S/c1-31(23-27-5-6-35-23)10-12-11-36-20(18(12)26)22(33)30-19-15(7-14(25)8-16(19)34-2)21(32)29-17-4-3-13(24)9-28-17/h3-4,7-9,11H,5-6,10H2,1-2H3,(H,30,33)(H,28,29,32)
|
|||
InChIKey |
FBXIHZSULWMHJY-UHFFFAOYSA-N
|
|||
PubChem Compound ID |
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Coagulation factor Xa (F10) | Target Info | Inhibitor | [1] |
Plasma kallikrein (KLKB1) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Complement and coagulation cascades | |||
NetPath Pathway | AndrogenReceptor Signaling Pathway | |||
Panther Pathway | Blood coagulation | |||
Pathwhiz Pathway | Coagulation | |||
Pathway Interaction Database | Beta2 integrin cell surface interactions | |||
Reactome | Intrinsic Pathway of Fibrin Clot Formation | |||
Activation of Matrix Metalloproteinases | ||||
Extrinsic Pathway of Fibrin Clot Formation | ||||
Common Pathway of Fibrin Clot Formation | ||||
Gamma-carboxylation of protein precursors | ||||
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus | ||||
Removal of aminoterminal propeptides from gamma-carboxylated proteins | ||||
WikiPathways | Complement and Coagulation Cascades | |||
Human Complement System | ||||
Blood Clotting Cascade | ||||
Formation of Fibrin Clot (Clotting Cascade) | ||||
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
References | Top | |||
---|---|---|---|---|
REF 1 | Thiophene-anthranilamides as highly potent and orally available factor Xa inhibitors. J Med Chem. 2007 Jun 28;50(13):2967-80. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.