Drug Information | Therapeutic Target Database

Drug General Information

Drug ID

D0S7IE

Former ID

DNC006663

Drug Name

N-(4-amino-5-cyano-6-phenylpyridin-2-yl)acetamide

Synonyms

N-(4-amino-5-cyano-6-phenylpyridin-2-yl)acetamide; Kinome_3019; CHEMBL210032; SCHEMBL1145340; BDBM15968; Aminopyridine-Based Inhibitor 24

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Drug Type

Small molecular drug

Indication

Discovery agent [ICD-11: N.A.]

Investigative

[1]

Structure

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2D MOL

Formula

C14H12N4O

Canonical SMILES

CC(=O)NC1=NC(=C(C(=C1)N)C#N)C2=CC=CC=C2

InChI

1S/C14H12N4O/c1-9(19)17-13-7-12(16)11(8-15)14(18-13)10-5-3-2-4-6-10/h2-7H,1H3,(H3,16,17,18,19)

InChIKey

GTMGQYXCPKUZAD-UHFFFAOYSA-N

PubChem Compound ID

11658882

Target and Pathway

Target(s)

Cyclin-dependent kinase 2 (CDK2)

Target Info

Inhibitor

[1]

IKKA messenger RNA (IKKA mRNA)

Target Info

Inhibitor

[1]

JNK2 messenger RNA (JNK2 mRNA)

Target Info

Inhibitor

[1]

Stress-activated protein kinase JNK1 (JNK1)

Target Info

Inhibitor

[1]

Stress-activated protein kinase JNK3 (JNK3)

Target Info

Inhibitor

[1]

KEGG Pathway

MAPK signaling pathway

ErbB signaling pathway

Ras signaling pathway

cAMP signaling pathway

FoxO signaling pathway

Sphingolipid signaling pathway

Protein processing in endoplasmic reticulum

Wnt signaling pathway

Osteoclast differentiation

Focal adhesion

Toll-like receptor signaling pathway

NOD-like receptor signaling pathway

RIG-I-like receptor signaling pathway

T cell receptor signaling pathway

Fc epsilon RI signaling pathway

TNF signaling pathway

Neurotrophin signaling pathway

Retrograde endocannabinoid signaling

Dopaminergic synapse

Inflammatory mediator regulation of TRP channels

Insulin signaling pathway

GnRH signaling pathway

Progesterone-mediated oocyte maturation

Prolactin signaling pathway

Adipocytokine signaling pathway

Type II diabetes mellitus

Non-alcoholic fatty liver disease (NAFLD)

Epithelial cell signaling in Helicobacter pylori infection

Shigellosis

Salmonella infection

Pertussis

Chagas disease (American trypanosomiasis)

Toxoplasmosis

Tuberculosis

Hepatitis C

Hepatitis B

Influenza A

Herpes simplex infection

Epstein-Barr virus infection

Pathways in cancer

Colorectal cancer

Pancreatic cancer

Choline metabolism in cancer

Cell cycle

Oocyte meiosis

p53 signaling pathway

PI3K-Akt signaling pathway

Measles

Viral carcinogenesis

Prostate cancer

Small cell lung cancer

HTLV-I infection

Chemokine signaling pathway

NF-kappa B signaling pathway

Apoptosis

Cytosolic DNA-sensing pathway

B cell receptor signaling pathway

Chronic myeloid leukemia

Acute myeloid leukemia

NetPath Pathway

TCR Signaling Pathway

IL5 Signaling Pathway

TNFalpha Signaling Pathway

FSH Signaling Pathway

Panther Pathway

Alzheimer disease-amyloid secretase pathway

Apoptosis signaling pathway

B cell activation

FAS signaling pathway

Huntington disease

Integrin signalling pathway

Interferon-gamma signaling pathway

Oxidative stress response

Parkinson disease

TGF-beta signaling pathway

T cell activation

Toll receptor signaling pathway

Ras Pathway

CCKR signaling map ST

p53 pathway

p53 pathway feedback loops 2

EGF receptor signaling pathway

FGF signaling pathway

Angiogenesis

PDGF signaling pathway

Inflammation mediated by chemokine and cytokine signaling pathway

Interleukin signaling pathway

Pathwhiz Pathway

Intracellular Signalling Through Adenosine Receptor A2a and Adenosine

Intracellular Signalling Through Adenosine Receptor A2b and Adenosine

Fc Epsilon Receptor I Signaling in Mast Cells

Pathway Interaction Database

Noncanonical Wnt signaling pathway

CD40/CD40L signaling

CDC42 signaling events

FAS (CD95) signaling pathway

Role of Calcineurin-dependent NFAT signaling in lymphocytes

Glucocorticoid receptor regulatory network

IL2-mediated signaling events

Rapid glucocorticoid signaling

FoxO family signaling

p75(NTR)-mediated signaling

ErbB1 downstream signaling

ATF-2 transcription factor network

ErbB2/ErbB3 signaling events

PDGFR-beta signaling pathway

Nephrin/Neph1 signaling in the kidney podocyte

p53 pathway

Downstream signaling in na&#xef

RAC1 signaling pathway

Regulation of retinoblastoma protein

Signaling events mediated by focal adhesion kinase

Glypican 3 network

IL12 signaling mediated by STAT4

Regulation of nuclear SMAD2/3 signaling

Signaling events mediated by PRL

p73 transcription factor network

E2F transcription factor network

ATR signaling pathway

mTOR signaling pathway

FOXM1 transcription factor network

BARD1 signaling events

Fc-epsilon receptor I signaling in mast cells

Endothelins

BCR signaling pathway

RhoA signaling pathway

Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

Osteopontin-mediated events

Reelin signaling pathway

TRAIL signaling pathway

Signaling events regulated by Ret tyrosine kinase

Angiopoietin receptor Tie2-mediated signaling

IL1-mediated signaling events

Ceramide signaling pathway

Regulation of Androgen receptor activity

JNK signaling in the CD4+ TCR pathway

HIV-1 Nef: Negative effector of Fas and TNF-alpha

Retinoic acid receptors-mediated signaling

Signaling events mediated by Stem cell factor receptor (c-Kit)

EPO signaling pathway

Syndecan-2-mediated signaling events

Ephrin B reverse signaling

N-cadherin signaling events

S1P2 pathway

TCR signaling in na&#xef

Canonical NF-kappaB pathway

Alternative NF-kappaB pathway

TCR signaling in na&#xef

TNF receptor signaling pathway

Validated nuclear estrogen receptor alpha network

Class I PI3K signaling events mediated by Akt

Validated transcriptional targets of TAp63 isoforms

Endogenous TLR signaling

Reactome

Oxidative Stress Induced Senescence

FCERI mediated MAPK activation

JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1

Activation of the AP-1 family of transcription factors

G0 and Early G1

Activation of ATR in response to replication stress

Regulation of APC/C activators between G1/S and early anaphase

SCF(Skp2)-mediated degradation of p27/p21

Senescence-Associated Secretory Phenotype (SASP)

DNA Damage/Telomere Stress Induced Senescence

Processing of DNA double-strand break ends

G2 Phase

Orc1 removal from chromatin

Cyclin E associated events during G1/S transition

Cyclin A/B1 associated events during G2/M transition

p53-Dependent G1 DNA Damage Response

Cyclin A:Cdk2-associated events at S phase entry

Meiotic recombination

Factors involved in megakaryocyte development and platelet production

NRAGE signals death through JNK

NRIF signals cell death from the nucleus

DSCAM interactions

Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Activation of NF-kappaB in B cells

NOD1/2 Signaling Pathway

RIP-mediated NFkB activation via ZBP1

AKT phosphorylates targets in the cytosol

FCERI mediated NF-kB activation

TAK1 activates NFkB by phosphorylation and activation of IKKs complex

Interleukin-1 signaling

Regulation of TNFR1 signaling

TNFR1-induced NFkappaB signaling pathway

IKBKB deficiency causes SCID

IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)

IkBA variant leads to EDA-ID

Dectin-1 mediated noncanonical NF-kB signaling

CLEC7A (Dectin-1) signaling

Constitutive Signaling by AKT1 E17K in Cancer

NIK-->noncanonical NF-kB signaling

MAP3K8 (TPL2)-dependent MAPK1/3 activation

TRAF6 mediated NF-kB activation

NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10

IRAK1 recruits IKK complex

IKK complex recruitment mediated by RIP1

IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

WikiPathways

Toll-like receptor signaling pathway

DNA Damage Response (only ATM dependent)

TCR Signaling Pathway

TGF Beta Signaling Pathway

Insulin Signaling

EGF/EGFR Signaling Pathway

Wnt Signaling Pathway

Wnt Signaling Pathway and Pluripotency

TGF beta Signaling Pathway

Wnt Signaling Pathway Netpath

Nanoparticle-mediated activation of receptor signaling

Structural Pathway of Interleukin 1 (IL-1)

JAK/STAT

ATM Signaling Pathway

BDNF signaling pathway

Integrated Pancreatic Cancer Pathway

Oncostatin M Signaling Pathway

Corticotropin-releasing hormone

AGE/RAGE pathway

TNF alpha Signaling Pathway

B Cell Receptor Signaling Pathway

TSLP Signaling Pathway

TWEAK Signaling Pathway

RANKL/RANK Signaling Pathway

IL-1 signaling pathway

Regulation of toll-like receptor signaling pathway

DNA Damage Response

ID signaling pathway

DNA Replication

G1 to S cell cycle control

M/G1 Transition

S Phase

Meiotic Recombination

Aryl Hydrocarbon Receptor

Retinoblastoma (RB) in Cancer

Spinal Cord Injury

Prostate Cancer

Signaling Pathways in Glioblastoma

TSH signaling pathway

Integrated Breast Cancer Pathway

Integrated Cancer pathway

Synthesis of DNA

Regulation of DNA replication

Mitotic G2-G2/M phases

Mitotic G1-G1/S phases

Factors involved in megakaryocyte development and platelet production

Cell Cycle

APC/C-mediated degradation of cell cycle proteins

Cell Cycle Checkpoints

miRNA Regulation of DNA Damage Response

G13 Signaling Pathway

MAPK Cascade

Oxidative Stress

Apoptosis Modulation by HSP70

MAPK Signaling Pathway

Apoptosis

Integrin-mediated Cell Adhesion

ErbB Signaling Pathway

FAS pathway and Stress induction of HSP regulation

Signaling of Hepatocyte Growth Factor Receptor

Kit receptor signaling pathway

Transcriptional activation by NRF2

NLR Proteins

IL-3 Signaling Pathway

Cardiac Hypertrophic Response

EBV LMP1 signaling

PDGF Pathway

Nanoparticle triggered regulated necrosis

Leptin signaling pathway

Signalling by NGF

Intrinsic Pathway for Apoptosis

DSCAM interactions

Apoptosis Modulation and Signaling

Type II diabetes mellitus

MicroRNAs in cardiomyocyte hypertrophy

Physiological and Pathological Hypertrophy of the Heart

Osteoclast Signaling

References

REF 1

Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80.

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