miRNA General Information
miRNA Mature ID hsa-miR-139-5p
miRNA Stemloop AC MI0000261
miRNA Stemloop ID hsa-mir-139
Sequence ucuacagugcacgugucuccagu
TTD Target(s) Regulated by This miRNA Insulin-like growth factor I receptor (IGF1R) Successful Target Target Info [1]
PI3-kinase alpha (PIK3CA) Successful Target Target Info [2]
Proto-oncogene c-Met (MET) Successful Target Target Info [3]
Apoptosis regulator Bcl-2 (BCL-2) Successful Target Target Info [4]
C-X-C chemokine receptor type 4 (CXCR4) Successful Target Target Info [5]
Phosphodiesterase 4D (PDE4D) Successful Target Target Info [6]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) Clinical trial Target Target Info [7]
Rho-associated protein kinase 2 (ROCK2) Successful Target Target Info [8]
DNA-binding factor KBF1 (p105) Clinical trial Target Target Info [2]
Notch-1 receptor (NOTCH1) Clinical trial Target Target Info [9]
Transcription factor AP-1 (JUN) Discontinued Target Target Info [10]
Matrix metalloproteinase-11 (MMP-11) Literature-reported Target Target Info [11]
Mitotic growth and transcription activator (BAF190A) Literature-reported Target Target Info [12]
GTPase HRas (HRAS) Literature-reported Target Target Info [2]
Liver receptor homolog-1 (NR5A2) Literature-reported Target Target Info [13]
Proto-oncogene c-Fos (c-Fos) Literature-reported Target Target Info [14]
Protein(s) Regulated by This miRNA Actin, alpha cardiac muscle 1 Regulated Protein [15]
Adhesion G protein-coupled receptor L4 Regulated Protein [16]
Mitochondrial Rho GTPase 1 Regulated Protein [2]
Protein FAM162A Regulated Protein [18]
Protein Mis18-beta Regulated Protein [19]
Proto-oncogene Wnt-1 Regulated Protein [20]
Ras-related protein Rap-1b Regulated Protein [8]
Tumor protein D52 Regulated Protein [22]
Zinc fingers and homeoboxes protein 2 Regulated Protein [2]
References
REF 1 MiR-139 inhibits invasion and metastasis of colorectal cancer by targeting the type I insulin-like growth factor receptor. Biochem Pharmacol. 2012 Aug 1;84(3):320-30.
REF 2 miR-139-5p is a regulator of metastatic pathways in breast cancer. RNA. 2013 Dec;19(12):1767-80.
REF 3 Hsa-miR-139-5p inhibits proliferation and causes apoptosis associated with down-regulation of c-Met. Oncotarget. 2015 Nov 24;6(37):39756-92.
REF 4 miR-139-5p Inhibits the Epithelial-Mesenchymal Transition and Enhances the Chemotherapeutic Sensitivity of Colorectal Cancer Cells by Downregulating BCL2. Sci Rep. 2016 May 31;6:27157.
REF 5 HER2 interacts with CD44 to up-regulate CXCR4 via epigenetic silencing of microRNA-139 in gastric cancer cells. Gastroenterology. 2011 Dec;141(6):2076-2087.e6.
REF 6 Inactivation of oncogenic cAMP-specific phosphodiesterase 4D by miR-139-5p in response to p53 activation. Elife. 2016 Jul 7;5. pii: e15978.
REF 7 MiR-139 inhibits Mcl-1 expression and potentiates TMZ-induced apoptosis in glioma. CNS Neurosci Ther. 2013 Jul;19(7):477-83.
REF 8 Post-transcriptional regulation of the tumor suppressor miR-139-5p and a network of miR-139-5p-mediated mRNA interactions in colorectal cancer. FEBS J. 2014 Aug;281(16):3609-24.
REF 9 microRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer. Mol Cancer. 2014 May 26;13:124.
REF 10 Involvement of aberrant miR-139/Jun feedback loop in human gastric cancer. Biochim Biophys Acta. 2015 Feb;1853(2):481-8.
REF 11 Dual tumor-suppressors miR-139-5p and miR-139-3p targeting matrix metalloprotease 11 in bladder cancer. Cancer Sci. 2016 Sep;107(9):1233-42.
REF 12 MicroRNA-139-5p regulates proliferation of hematopoietic progenitors and is repressed during BCR-ABL-mediated leukemogenesis. Blood. 2016 Oct 27;128(17):2117-2129.
REF 13 Tumor-suppressive function of miR-139-5p in esophageal squamous cell carcinoma. PLoS One. 2013 Oct 18;8(10):e77068.
REF 14 Derepression of c-Fos caused by microRNA-139 down-regulation contributes to the metastasis of human hepatocellular carcinoma. Cell Biochem Funct. 2013 Jun;31(4):319-24.
REF 15 A gain-of-function ACTC1 3'UTR mutation that introduces a miR-139-5p target site may be associated with a dominant familial atrial septal defect.Sci Rep. 2016 May 3;6:25404.
REF 16 MicroRNA-139-5p acts as a tumor suppressor by targeting ELTD1 and regulating cell cycle in glioblastoma multiforme.Biochem Biophys Res Commun. 2015 Nov 13;467(2):204-10.
REF 17 miR-139-5p is a regulator of metastatic pathways in breast cancer. RNA. 2013 Dec;19(12):1767-80.
REF 18 MiR-139-5p inhibits HGTD-P and regulates neuronal apoptosis induced by hypoxia-ischemia in neonatal rats.Neurobiol Dis. 2014 Mar;63:184-93.
REF 19 Loss of the Opa interacting protein 5 inhibits breast cancer proliferation through miR-139-5p/NOTCH1 pathway.Gene. 2017 Mar 1;603:1-8.
REF 20 MicroRNA-139-5p regulates C2C12 cell myogenesis through blocking Wnt/-catenin signaling pathway.Biochem Cell Biol. 2015 Feb;93(1):8-15.
REF 21 Post-transcriptional regulation of the tumor suppressor miR-139-5p and a network of miR-139-5p-mediated mRNA interactions in colorectal cancer. FEBS J. 2014 Aug;281(16):3609-24.
REF 22 miR-139-5p regulates proliferation, apoptosis, and cell cycle of uterine leiomyoma cells by targeting TPD52. Onco Targets Ther. 2016 Oct 11;9:6151-6160.

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