Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T83875 Target Info
Target Name Monoamine oxidase type A (MAO-A)
Synonyms Monoamine oxidase A; Amine oxidase [flavin-containing] A
Target Type Successful Target
Gene Name MAOA
Biochemical Class CH-NH(2) donor oxidoreductase
UniProt ID
AOFA_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
World Intellectual Property Organization (WIPO)
Patent ID WO2013016580
Title Monoamine Oxidase Inhibitors and Methods for Treatment and Diagnosis of Prostate Cancer.
Abstract A mechanism of monoamine oxidases (MAOs) driven epithelium-to-mesenchymal transition (EMT) is disclosed. Also disclosed are methods for treating cancer by inhibiting or suppressing MAOs in cancer cells. Novel MAOs inhibitors, such as small molecules, siRNA, shRNA, antisense oligonucleotides, aptamers, decoys, and pharmaceutical compositions useful for treating cancer by disrupting the workings of MAOs are provided. In particular, a class of conjugates formed by covalently conjugating near infrared dye 783, IR-780, and MHI-148 to a MAO inhibitor, such as clorgyline, with and without encapsulation it in a nanoparticle is provided. Other aspects of the invention include methods for forming the nano-conjugates, method for monitoring treatment progress in a cancer patient by monitoring the changes in MAO activity, methods for screening patients who are at risk of cancer or differentiating different forms of cancer by assaying the level and location of MAO activity.
Applicant(s) University of Southern California
Representative Drug(s) D01ZSO Drug Info N.A. Click to Show More [1]
2 D09QDP Drug Info N.A. [1]
3 D0H0HJ Drug Info N.A. [1]
Patent ID WO2012051374
Title Use of Monoamine Oxidase Inhibitors To Improve Epithelial Biology.
Abstract The invention provides a method for improving hair biology, e.g., hair growth. The method comprises administering to a subject a monoamine oxidase inhibitor and a vasodilator, a zinc salt of a carboxylic acid, a xanthine compound, pyrithione or a salt thereof, saponin, tritapene, crataegolic acid, celastrol, asiatic acid, an inhibitor of 5-alpha-reductase, 1,4-methyl-4-azasteroid, an androgen receptor antagonist, azelaic acid or a derivate thereof, cyclosporin, triiodothyronine, diazoxide, retinoic acid, a prostaglandin analogue, aminexil, carnitine tartrate, apigenin, procapil, or adenosine, in an amount effective to achieve a desired effect. The invention further provides a method of reducing or delaying the appearance of an age-related skin imperfection. The method comprises administering to the subject a composition comprising an MAO inhibitor. A kit for improving hair growth also is provided.
Applicant(s) Procter & Gamble
Representative Drug(s) D01ZSO Drug Info N.A. Click to Show More [1]
2 D09QDP Drug Info N.A. [1]
Patent ID WO2014056070
Title (-)-Deprenyl and Related Compounds for The Treatment of Alopecia.
Abstract The present invention includes methods of preventing or minimizing cancer therapy induced alopecia (hair loss) in a subject, the method including administering to the subject an effective amount of (-)-deprenyl, a related compound, or a salt thereof. The present invention also includes methods of preventing or minimizing additional side effects of cancer therapies other than cancer therapy induced alopecia by the administration of an effective amount of (-)- deprenyl, a related compound, or a salt thereof.
Applicant(s) Brandon University
Patent ID WO2013182625
Title Pharmaceutical formulation with Propargylamine Compound.
Abstract Stable pharmaceutical formulations comprising a propargylamine monoamine oxidase inhibitor compound such as rasagiline or salt thereof, e.g. rasagiline tartrate, mesylate, succinate or hydrochloride. The formulations contain calcium sulphate as inert excipient, preferably in the form of calcium sulphate dihydrate. The formulations may additionally contain a weak acid such as critic acid, which enhances stability further.
Applicant(s) Actavis Group Ptc Ehf
Patent ID WO2013118126
Title Ladostigil Therapy for Immunomodulation.
Abstract Methods for treating individuals suffering from inflammation, specifically systemic inflammation including septic shock and inflammatory conditions affecting the gastrointestinal, myocardial and endocrine systems with ladostigil, are provided.
Applicant(s) Yissum Research Development Company of the Hebrew University of Jerusalem Ltd
Patent ID WO2013070526
Title Methods for The Treatment of Skin Neoplasms.
Abstract Methods of treating skin neoplasms using a monoamine oxidase inhibitor, e.g., a propynylaminoindan (such as rasagiline) are provided. Pharmaceutical compositions and kits comprising monoamine oxidase inhibitors are also provided.
Applicant(s) Teikoku Pharma Usa, Inc
Patent ID WO2012050594
Title Treatment for Cocaine Addiction.
Abstract A novel pharmaceutical composition is provided for the control of stimulant effects, in particular treatment of cocaine addiction, or further to treatment of both cocaine and alcohol dependency, including simultaneous therapeutic dose application or a single dose of a combined therapeutically effective composition of disulfiram and selegiline compounds or pharmaceutically acceptable non-toxic salt thereof.
Applicant(s) Tonix Pharmaceuticals, Inc
Patent ID WO085437
Title Combinations for The Treatment of Dementia, and The Enhancement of Cognitive Function.
Applicant(s) The Wwk Trust & Jd Med Services
United States Patent and Trademark Office (USPTO)
Patent ID US20140186280
Title Neuroprotective and Neurorestorative Iron Chelators and Monoamine Oxidase Inhibitors and Uses Thereof.
Applicant(s) Varinel, Inc
Representative Drug(s) D03EHC Drug Info IC50(rat) = 200 nM Click to Show More [1]
2 D03VGN Drug Info IC50 = 250 to 300 nM [1]
Patent ID US20120329800
Title Treatment of Muscular Dystrophies and Associated Conditions By Administration of Monoamine Oxidase Inhibitors.
Applicant(s) University of Padua
Patent ID US20100324147
Title Trans-2-Arylcyclopropylamine Derivatives As Inhibitors of Lysine-Specific Demethylase 1, Monoamine Oxidase A and B, and Their Preparation and Use for The Treatment of Cancer.
Applicant(s) Duke University, Usa
Patent ID US0320742
Title Combinations Comprising 3-Phenyl-Sulfonyl-8-Piperazin-1-Yl-Quinoline.
Applicant(s) Axovant Sciences Ltd
Patent ID US0290201
Title Treatment of Muscular Distrophies and Associated Conditions By Administration of Monoamine Oxidase Inhibitors.
Applicant(s) Universit Degli Studi Di Padova, Italy
Patent ID US0182018
Title Treatment of Dopaminergic Disorders.
Applicant(s) Northwestern University
Patent ID US0143902
Title Combination of Morphinan Compounds and Antidepressant for The Treatment of Pseudobulbar Affect, Neurological Diseases, Intractable and Chronic Pain and Brain Injury.
Applicant(s) Concert Pharmaceuticals, Inc
Patent ID US0067187
Title Methods for Treating or Preventing Migraines.
Applicant(s) Validus Pharmaceuticals Llc
Patent ID US0038550
Title Methods and Compositions for Treating Conditions Associated with Memory Loss.
Patent ID US0029371
Title Mao Inhibitors and Their Conjugates As Therapeutics for The Treatment of Brain Cancer.
China National Intellectual Property Administration (CNIPA)
Patent ID CN2014103638011
Title Application of Artoxanthochromane To Monoamine Oxidase (Mao) Inhibitor.
Applicant(s) Changzhou Kelixin Medical Devices Co Ltd
Representative Drug(s) D03QMA Drug Info IC50 = 54 nM [1]
Patent ID CN2014103479634
Title Application ofLycojaconicumin A for Preparing Monoamine Oxidase (Mao) Inhibitor Drugs.
Applicant(s) Nanjing Guangkangxie Biolog. Medical Technology Co Ltd
Representative Drug(s) D0M0EP Drug Info IC50 = 35 nM [1]
Patent ID CN2013103463101
Title Application of Kadcoccitones A In Preparing Monoamine Oxidase (Mao) Inhibitor.
Applicant(s) Nanjing Zhengliang Med. Tech. Co
Representative Drug(s) D0G3TH Drug Info IC50 = 35 nM [1]
Patent ID CN2013103463079
Title Application of Lycojaconicumin C In Monoamine Oxidase Inhibitor Medicine.
Applicant(s) Nanjing Guangkangxie Biolog. Medical Technology Co Ltd
Representative Drug(s) D0H7HH Drug Info IC50 = 46 nM [1]
Patent ID CN2013103463036
Title Application of Lycojaconicumin B In Monoamine Oxidase Inhibitor Medicine.
Applicant(s) Nanjing Guangkangxie Biolog. Medical Technology Co Ltd
Representative Drug(s) D0E7OQ Drug Info IC50 = 41 nM [1]
Patent ID CN2013103446096
Title Application of Incarviatone A In Monoamine Oxidase Inhibitor Drug.
Applicant(s) Nanjing Zhengliang Med. Tech. Co
Representative Drug(s) D0LZ2M Drug Info IC50 = 29 nM [1]
Patent ID CN2013103251602
Title Application of Myriberine A In Preparation of Monoamine Oxidase (Mao) Inhibitor.
Applicant(s) Nanjing Zhengliang Med. Tech. Co
Representative Drug(s) D0I9CK Drug Info IC50 = 29 nM [1]
Patent ID CN105534964
Title Application of Substituted Aryl Amides, or Nitrogen-Containing Heterocyclic Compounds In Manufacture of Monoamine Oxidase Inhibitor.
Applicant(s) University Zhejiang Technology
Representative Drug(s) D01OGR Drug Info IC50 = 37950 nM [2]
Patent ID CN105503840
Title Tacrine-Coumarin Derivative Containing Triazole and Application of Derivative.
Applicant(s) University Guangdong Technology
Representative Drug(s) D0T9JB Drug Info IC50 > 100000 nM [2]
Patent ID CN105017195
Title 4-Hydroxycoumarin-3-Schiff Base Derivate and Use Thereof for Curing AlzheimerS Disease.
Applicant(s) University China Pharma
Representative Drug(s) D05RJG Drug Info IC50 = 673 nM [2]
Patent ID CN2014103520185
Title Application of Compound In Preparing Monoamine Oxidase Mao Inhibitor.
Representative Drug(s) D07MEE Drug Info IC50 = 45 nM [1]
Patent ID CN2014103520155
Title Application of Neonectrolide A In Preparing Mao (Monoamine Oxidase) Inhibitor.
Patent ID CN2013103463010
Title Application of Fluevirosines A In Monoamine Oxidase Inhibitor.
Representative Drug(s) D0KW7O Drug Info IC50 = 39 nM [1]
Patent ID CN2013103462983
Title Application of Spirooliganones B In Preparation of Monoamine Oxidase (Mao) Inhibitor.
Representative Drug(s) D0I5DV Drug Info IC50 = 42 nM [1]
Patent ID CN2013103393675
Title Application of Aphanamgrandiol A In Preparing Monoamine Oxidase (Mao) Inhibitor.
Patent ID CN2013103393643
Title Application of Sarcaboside A To Monoamine Oxidase Inhibitor.
Representative Drug(s) D05GWJ Drug Info IC50 = 39 nM [1]
Patent ID CN2013103356652
Title Application of Chukrasone A In Preparing Mao (Monoamine Oxidase) Inhibitor Medicines.
Representative Drug(s) D0K3UV Drug Info IC50 = 31 nM [1]
Patent ID CN2013103356601
Title Application of Chukrasone B In Preparing Mao (Monoamine Oxidase) Inhibitor Medicines.
Patent ID CN2013103356544
Title Application of Sarcaboside B In Monoamine Oxidase Inhibitor Drug.
Representative Drug(s) D05MYL Drug Info IC50 = 31 nM [1]
Patent ID CN2013103285012
Title Application of Aspeverin To The Preparation of Inhibitors of Monoamine Oxidase (Mao).
Representative Drug(s) D08HOV Drug Info IC50 = 39 nM [1]
Patent ID CN2013103120674
Title Application of Erymgiolide A In Preparing Mao (Monoamine Oxidase) Inhibitor.
Representative Drug(s) D0N1CG Drug Info IC50 = 31 nM [1]
Patent ID CN2013103120673
Title Application of Aphanamixoid A To Preparation of Monoamine Oxidase (Mao) Inhibitor.
Representative Drug(s) D0TX9E Drug Info IC50 = 32 nM [1]
Patent ID CN2013102988397
Title Application of Houttuynoid A for Preparing Mao (Monoamine Oxidase) Inhibitor Medicine.
Representative Drug(s) D0P1PC Drug Info IC50 = 32 nM [1]
Patent ID CN2013102885830
Title Application of Gypensapogenin B To Preparation of Mao (Monoamine Oxidase) Inhibitor.
Representative Drug(s) D0R2YC Drug Info IC50 = 39 nM [1]
Patent ID CN2013102885825
Title Application of Gypensapogenin A In Monoamine Oxidase (Mao) Inhibitor.
Representative Drug(s) D03YOU Drug Info IC50 = 31 nM [1]
Patent ID CN105153195
Title Tricyclo-Pyrazole [1,5-D] [1,4] Benzo Oxazepine-One Derivatives and Preparation Method and Application Thereof.
Representative Drug(s) D0AH9P Drug Info IC50 = 26900 nM [2]
Korean Intellectual Property Office (KIPO)
Patent ID KR20120089882
Title Composition Comprising The Extract of Loranthus Yadoriki Sieb. Having Monoamine Oxidase-Inhibiting Activity.
Applicant(s) Nat Arboretum Korea Forest Service
Intellectual Property Office of United Kingdom (IPOUK)
Patent ID GB25327444
Title A Chocolate Composition Comprising A Monoamine Oxidase Inhibitor.
References  Top
REF 1 Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110.
REF 2 MAO inhibitors and their wider applications: a patent review.Expert Opin Ther Pat. 2018 Mar;28(3):211-226.
REF 3 LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80.

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