Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | AP-2 transcription factor (TFAP2A) | Literature-reported | Target Info | ||
| UniProt ID | AP2A_HUMAN | ||||
| Gene Name | TFAP2A | ||||
| Gene ID | 7020 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Clinical trial Target(s) | Cellular tumor antigen p53 (TP53) | Target Info | PPI Info | [1] | |
| Nucleophosmin (NPM1) | Target Info | PPI Info | [2] | ||
| Transcription factor Sp1 (SP1) | Target Info | PPI Info | [3] | ||
| Histone acetyltransferase p300 (EP300) | Target Info | PPI Info | [4] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Tumor suppressor activity of AP2alpha mediated through a direct interaction with p53. J Biol Chem. 2002 Nov 22;277(47):45028-33. | ||||
| REF 2 | Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation. EMBO Rep. 2007 Apr;8(4):394-400. | ||||
| REF 3 | Modulation of IFN- receptor 1 expression by AP-2 influences IFN- sensitivity of cancer cells. Am J Pathol. 2012 Feb;180(2):661-71. | ||||
| REF 4 | Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2. J Biol Chem. 2003 May 2;278(18):16021-9. | ||||
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