Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T61544 Target Info
Target Name Transcription factor Sp1 (SP1)
Synonyms TSFP1
Target Type Clinical trial Target
Gene Name SP1
UniProt ID
SP1_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Target Name Mitotic growth and transcription activator (BAF190A) Literature-reported Target Interacting Protein Info
UniProt ID
SMCA4_HUMAN 
Synonyms Transcription activator BRG1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; SNF2L4; SNF2-beta; SNF2B; Protein BRG-1; Protein brahma homolog 1; BRG1-associated factor 190A; BRG1; ATP-dependent helicase SMARCA4
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Reconstituted Complex [3]
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 13 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Affinity Capture-Western [5]
3 Affinity Capture-Western [6]
4 Affinity Capture-Western [7]
5 Affinity Capture-Western [8]
6 Affinity Capture-Western [9]
7 Biochemical Activity [6]
8 Co-localization [10]
9 Reconstituted Complex [6]
10 Reconstituted Complex [8]
11 Reconstituted Complex [11]
12 Yeast two hybrid [10]
13 Yeast two hybrid [9]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Affinity Capture-Western [13]
3 Affinity Capture-Western [14]
4 Affinity Capture-Western [15]
5 Affinity Capture-Western [6]
6 Affinity Capture-Western [16]
7 Affinity Capture-Western [17]
8 Affinity Capture-Western [4]
9 Affinity Capture-Western [7]
10 Affinity Capture-Western [18]
11 Affinity Capture-Western [19]
12 Affinity Capture-Western [20]
13 Affinity Capture-Western [21]
14 Affinity Capture-Western [22]
15 Affinity Capture-Western [23]
16 Affinity Capture-Western [24]
17 Affinity Capture-Western [25]
18 Affinity Capture-Western [26]
19 Affinity Capture-Western [27]
20 Reconstituted Complex [28]
Cell cycle related proteins [+] 1 Cell cycle related proteins +
Interacting Target Name Cyclin A2 (CCNA2) Literature-reported Target Interacting Protein Info
UniProt ID
CCNA2_HUMAN 
Synonyms Cyclin-A2; Cyclin-A; Cyclin A; CCNA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [29]
2 Reconstituted Complex [30]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [31]
2 Affinity Capture-Western [32]
3 Reconstituted Complex [31]
Kinases [+] 3 Kinases +
Interacting Target Name Cyclin-dependent kinase 1 (CDK1) Clinical trial Target Interacting Protein Info
UniProt ID
CDK1_HUMAN 
Synonyms P34CDC2; P34 protein kinase; CDKN1; CDC28A; CDC2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [33]
2 Affinity Capture-Western [34]
3 Biochemical Activity [33]
4 Co-localization [33]
Interacting Target Name Protein kinase C delta (PRKCD) Clinical trial Target Interacting Protein Info
UniProt ID
KPCD_HUMAN 
Synonyms Tyrosine-protein kinase PRKCD; SDK1; Protein kinase C delta type catalytic subunit; Protein kinase C delta type; Protein Kinase C delta; PKC-delta; nPKC-delta
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [35]
2 Affinity Capture-Western [36]
3 Affinity Capture-Western [37]
4 Protein-peptide [36]
Interacting Target Name Protein kinase C zeta (PRKCZ) Patented-recorded Target Interacting Protein Info
UniProt ID
KPCZ_HUMAN 
Synonyms Protein kinase C zeta type; PKC2; NPKC-zeta
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [38]
2 Biochemical Activity [39]
Membrane-bounded channels [+] 1 Membrane-bounded channels +
Interacting Target Name G2/mitotic-specific cyclin B1 (CCNB1) Patented-recorded Target Interacting Protein Info
UniProt ID
CCNB1_HUMAN 
Synonyms G2/mitotic-specific cyclin-B1; Cyclin B1; CCNB
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [33]
2 Affinity Capture-Western [34]
3 Co-localization [33]
Nuclear hormone receptors [+] 4 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-Western [40]
2 Affinity Capture-Western [13]
3 Affinity Capture-Western [41]
4 Affinity Capture-Western [42]
5 Co-localization [43]
6 Co-localization [44]
7 Reconstituted Complex [45]
8 Reconstituted Complex [46]
9 Reconstituted Complex [47]
10 Reconstituted Complex [48]
Interacting Target Name Retinoic acid receptor alpha (RARA) Clinical trial Target Interacting Protein Info
UniProt ID
RARA_HUMAN 
Synonyms RAR-alpha; RAR alpha; Nuclear receptor subfamily 1 group B member 1; NR1B1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [49]
2 Co-localization [50]
3 Reconstituted Complex [50]
Interacting Target Name Peroxisome proliferator-activated receptor gamma (PPAR-gamma) Successful Target Interacting Protein Info
UniProt ID
PPARG_HUMAN 
Synonyms Transcription factor PPAR gamma receptor; PPAR-gamma; PPARgamma; Peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3; NR1C3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [51]
2 Reconstituted Complex [52]
Interacting Target Name Hepatocyte nuclear factor 4-alpha (HNF4A) Literature-reported Target Interacting Protein Info
UniProt ID
HNF4A_HUMAN 
Synonyms Transcription factor HNF-4; Transcription factor 14; TCF-14; TCF14; Nuclear receptor subfamily 2 group A member 1; NR2A1; HNF-4-alpha; HNF4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [53]
2 Reconstituted Complex [54]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [28]
2 Affinity Capture-Western [55]
3 Affinity Capture-Western [56]
4 Affinity Capture-Western [57]
5 Affinity Capture-Western [58]
6 Co-localization [59]
7 Reconstituted Complex [28]
8 Reconstituted Complex [60]
Transcription regulators [+] 21 Transcription regulators +
Interacting Protein Name Transcription factor Sp3 (SP3) Interacting Protein Interacting Protein Info
UniProt ID
SP3_HUMAN 
Synonyms SPR2
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [61]
2 Affinity Capture-Western [15]
3 Affinity Capture-Western [7]
4 Affinity Capture-Western [62]
5 Reconstituted Complex [63]
6 Reconstituted Complex [64]
7 Reconstituted Complex [62]
8 Reconstituted Complex [65]
Interacting Target Name Mothers against decapentaplegic homolog 3 (SMAD3) Successful Target Interacting Protein Info
UniProt ID
SMAD3_HUMAN 
Synonyms TGF-beta response effector Smad3; Smad3; SMAD family member 3; SMAD 3; Mothers against DPP homolog 3; MMad3; MADH3; Mad3; MAD homolog 3; JV15-2; HSMAD3; HMAD-3
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Luminescence [66]
2 Affinity Capture-Western [67]
3 Affinity Capture-Western [68]
4 Affinity Capture-Western [69]
5 Reconstituted Complex [68]
6 Yeast two hybrid [68]
Interacting Target Name Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Interacting Protein Info
UniProt ID
HIF1A_HUMAN 
Synonyms Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Luminescence [66]
2 Affinity Capture-Western [70]
3 Co-localization [71]
4 Reconstituted Complex [70]
5 Reconstituted Complex [71]
Interacting Protein Name POU class 2 homeobox 1 (POU2F1) Interacting Protein Interacting Protein Info
UniProt ID
PO2F1_HUMAN 
Synonyms OCT1; OTF1; oct.1B
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [72]
2 Reconstituted Complex [73]
3 Reconstituted Complex [72]
4 Reconstituted Complex [74]
5 Yeast two hybrid [73]
Interacting Target Name Proto-oncogene c-Myc (MYC) Literature-reported Target Interacting Protein Info
UniProt ID
MYC_HUMAN 
Synonyms Transcription factor p64; Proto-oncogene c-Myc; Myc proto-oncogene protein; C-myc oncogene; C-myc; Class E basic helix-loop-helix protein 39; bHLHe39
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [75]
2 Affinity Capture-Western [76]
3 Affinity Capture-Western [71]
4 Reconstituted Complex [71]
Interacting Protein Name Transcription factor p65 (RELA) Interacting Protein Interacting Protein Info
UniProt ID
TF65_HUMAN 
Synonyms NFKB3; p65
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [77]
2 Affinity Capture-Western [78]
3 Affinity Capture-Western [79]
4 Reconstituted Complex [80]
Interacting Protein Name Nuclear transcription factor Y subunit alpha (NFYA) Interacting Protein Interacting Protein Info
UniProt ID
NFYA_HUMAN 
Synonyms CBF.A; CBF.B; HAP2; NF.YA
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [81]
2 Reconstituted Complex [81]
3 Reconstituted Complex [82]
4 Yeast two hybrid [81]
Interacting Protein Name Mothers against decapentaplegic homolog 2 (SMAD2) Interacting Protein Interacting Protein Info
UniProt ID
SMAD2_HUMAN 
Synonyms JV18; JV18.1; MADH2; MADR2; hMAD.2; hSMAD2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [68]
2 Affinity Capture-Western [69]
3 Reconstituted Complex [68]
4 Yeast two hybrid [68]
Interacting Target Name Kruppel like factor 4 (KLF4) Clinical trial Target Interacting Protein Info
UniProt ID
KLF4_HUMAN 
Synonyms Krueppel-like factor 4; Krueppellike factor 4; Gut-enriched krueppel-like factor; Gutenriched krueppellike factor; GKLF; EZF; Epithelial zinc finger protein EZF
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [83]
2 Co-localization [83]
3 Reconstituted Complex [84]
Interacting Target Name Transcription factor AP-1 (JUN) Discontinued Target Interacting Protein Info
UniProt ID
JUN_HUMAN 
Synonyms V-jun avian sarcoma virus 17 oncogene homolog; Transcription factor AP-1; Proto-oncogene c-jun; P39; C-jun proto-oncogene; AP-1 transcription factor; AP1; Activator protein-1; Activator protein 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Affinity Capture-Western [85]
3 Reconstituted Complex [86]
Interacting Protein Name Activating transcription factor 7-interacting protein 1 (ATF7IP) Interacting Protein Interacting Protein Info
UniProt ID
MCAF1_HUMAN 
Synonyms AM; ATF.IP; MCAF; MCAF1; p621
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [87]
2 Reconstituted Complex [87]
3 Reconstituted Complex [88]
Interacting Protein Name Mothers against decapentaplegic homolog 4 (SMAD4) Interacting Protein Interacting Protein Info
UniProt ID
SMAD4_HUMAN 
Synonyms DPC4; JIP; MADH4; MYHRS
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [89]
2 Reconstituted Complex [68]
3 Yeast two hybrid [68]
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [33]
2 Affinity Capture-Western [90]
Interacting Target Name E2F transcription factor 1 (E2F1) Clinical trial Target Interacting Protein Info
UniProt ID
E2F1_HUMAN 
Synonyms Transcription factor E2F1; Retinoblastoma-binding protein 3; Retinoblastoma-associated protein 1; RBBP-3; RBBP3; RBAP-1; pRB-binding protein E2F-1; PBR3; E2F-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [91]
2 Reconstituted Complex [91]
Interacting Target Name High mobility group protein HMG-I/Y (HMGA1) Literature-reported Target Interacting Protein Info
UniProt ID
HMGA1_HUMAN 
Synonyms HMGIY; HMG-I(Y); High mobility group protein R; High mobility group protein HMG-I/HMG-Y; High mobility group protein A1; High mobility group AT-hook protein 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [92]
2 Reconstituted Complex [92]
Interacting Target Name Sterol regulatory element binding protein-1 (SREBF1) Literature-reported Target Interacting Protein Info
UniProt ID
SRBP1_HUMAN 
Synonyms Sterol regulatory element-binding transcription factor 1; Sterol regulatory element-binding protein 1; SREBP-1; SREBP1; SREBP 1; Class D basic helix-loop-helix protein 1; bHLHd1
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-purification [93]
2 Reconstituted Complex [94]
Interacting Target Name AP-2 transcription factor (TFAP2A) Literature-reported Target Interacting Protein Info
UniProt ID
AP2A_HUMAN 
Synonyms Transcription factor AP-2-alpha; TFAP2; AP2TF; AP2-alpha; AP-2; Activator protein 2; Activating enhancer-binding protein 2-alpha
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [95]
2 Reconstituted Complex [48]
Interacting Target Name Transcriptional repressor CTCFL (CTCFL) Literature-reported Target Interacting Protein Info
UniProt ID
CTCFL_HUMAN 
Synonyms Zinc finger protein CTCF-T; Transcriptional repressor CTCFL; CTCF-like protein; CTCF paralog; CT27; CCCTC-binding factor; Cancer/testis antigen 27; Brother of the regulator of imprinted sites; BORIS
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [96]
2 Reconstituted Complex [97]
Interacting Protein Name Transcription factor GATA-6 (GATA6) Interacting Protein Interacting Protein Info
UniProt ID
GATA6_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [98]
2 Reconstituted Complex [99]
Interacting Protein Name Activated RNA polymerase II transcriptional coactivator p15 (SUB1) Interacting Protein Interacting Protein Info
UniProt ID
TCP4_HUMAN 
Synonyms P15; PC4; p14
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [62]
2 Reconstituted Complex [100]
Interacting Protein Name TATA-box-binding protein (TBP) Interacting Protein Interacting Protein Info
UniProt ID
TBP_HUMAN 
Synonyms GTF2D; GTF2D1; HDL4; SCA17; TFIID
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [97]
2 Yeast two hybrid [101]
Other proteins [+] 1 Other proteins +
Interacting Target Name Beta-catenin (CTNNB1) Successful Target Interacting Protein Info
UniProt ID
CTNB1_HUMAN 
Synonyms Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [102]
2 Reconstituted Complex [102]
References  Top
REF 1 Maximal induction of a subset of interferon target genes requires the chromatin-remodeling activity of the BAF complex. Mol Cell Biol. 2002 Sep;22(18):6471-9.
REF 2 Modulation of extracellular matrix/adhesion molecule expression by BRG1 is associated with increased melanoma invasiveness. Mol Cancer. 2010 Oct 22;9:280.
REF 3 Functional selectivity of recombinant mammalian SWI/SNF subunits. Genes Dev. 2000 Oct 1;14(19):2441-51.
REF 4 Loss of NECL1, a novel tumor suppressor, can be restored in glioma by HDAC inhibitor-Trichostatin A through Sp1 binding site. Glia. 2009 Jul;57(9):989-99.
REF 5 The cellular senescence of leukemia-initiating cells from acute lymphoblastic leukemia is postponed by -Arrestin1 binding with P300-Sp1 to regulate hTERT transcription. Cell Death Dis. 2017 Apr 20;8(4):e2756.
REF 6 Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription. Mol Cell Biol. 2006 Mar;26(5):1770-85.
REF 7 Butyrate, a histone deacetylase inhibitor, activates the human IGF binding protein-3 promoter in breast cancer cells: molecular mechanism involves an Sp1/Sp3 multiprotein complex. Endocrinology. 2001 Sep;142(9):3817-27.
REF 8 ERK2-mediated C-terminal serine phosphorylation of p300 is vital to the regulation of epidermal growth factor-induced keratin 16 gene expression. J Biol Chem. 2007 Sep 14;282(37):27215-28.
REF 9 Sp1, acetylated histone-3 and p300 regulate TRAIL transcription: mechanisms of PDGF-BB-mediated VSMC proliferation and migration. J Cell Biochem. 2012 Aug;113(8):2597-606.
REF 10 P300 plays a role in p16(INK4a) expression and cell cycle arrest. Oncogene. 2008 Mar 20;27(13):1894-904.
REF 11 Activator-dependent transcription from chromatin in vitro involving targeted histone acetylation by p300. Mol Cell. 2000 Sep;6(3):551-61.
REF 12 Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter. J Biol Chem. 2003 Sep 19;278(38):36496-504.
REF 13 ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cyc... J Biol Chem. 2005 Feb 4;280(5):3185-96.
REF 14 The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2. J Biol Chem. 2002 Sep 27;277(39):35783-6.
REF 15 Trichostatin A, a histone deacetylase inhibitor, activates the IGFBP-3 promoter by upregulating Sp1 activity in hepatoma cells: alteration of the Sp1/Sp3/HDAC1 multiprotein complex. Biochem Biophys Res Commun. 2002 Aug 30;296(4):1005-12.
REF 16 Competitive inhibition of histone deacetylase activity by trichostatin A and butyrate. Biochem Cell Biol. 2007 Dec;85(6):751-8.
REF 17 Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex. J Biol Chem. 2002 Sep 6;277(36):33431-8.
REF 18 Constitutive expression of the Id-1 promoter in human metastatic breast cancer cells is linked with the loss of NF-1/Rb/HDAC-1 transcription repressor complex. Oncogene. 2002 Mar 14;21(12):1812-22.
REF 19 HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism. Oncogene. 2009 Jan 15;28(2):243-56.
REF 20 Histone deacetylase-1 represses transcription by interacting with zinc-fingers and interfering with the DNA binding activity of Sp1. Cell Physiol Biochem. 2005;16(1-3):23-30.
REF 21 Role of histone deacetylation in cell-specific expression of endothelial nitric-oxide synthase. J Biol Chem. 2005 Apr 22;280(16):16467-75.
REF 22 Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas. Mol Cell Biol. 2005 Mar;25(5):1608-19.
REF 23 The repressor element silencing transcription factor (REST)-mediated transcriptional repression requires the inhibition of Sp1. J Biol Chem. 2005 Jan 7;280(1):401-7.
REF 24 Restoration of transforming growth factor-beta signaling through receptor RI induction by histone deacetylase activity inhibition in breast cancer cells. J Biol Chem. 2004 Jul 30;279(31):32620-5.
REF 25 The interaction with Sp1 and reduction in the activity of histone deacetylase 1 are critical for the constitutive gene expression of IL-1 alpha in human melanoma cells. J Leukoc Biol. 2008 Jan;83(1):190-9.
REF 26 Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular accumulation of long-chain methotrexate polyglutamates in childhood acute lymphoblastic leukemia: implications for combination therapy. Leukemia. 2010 Mar;24(3):552-62.
REF 27 Epigenetic regulation of phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 gene expression in prostate cancer cells. J Biol Chem. 2011 Jul 22;286(29):25813-22.
REF 28 The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene. Mol Cell Biol. 2003 Apr;23(8):2669-79.
REF 29 Modulation of Sp1 activity by a cyclin A/CDK complex. J Mol Biol. 2001 Feb 16;306(2):201-12.
REF 30 Cyclin A-CDK phosphorylates Sp1 and enhances Sp1-mediated transcription. EMBO J. 2001 Oct 15;20(20):5737-47.
REF 31 Hsp90alpha recruited by Sp1 is important for transcription of 12(S)-lipoxygenase in A431 cells. J Biol Chem. 2005 Oct 28;280(43):36283-92.
REF 32 Heat shock protein 90 is important for Sp1 stability during mitosis. J Mol Biol. 2009 Apr 17;387(5):1106-19.
REF 33 Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells. Oncogene. 2012 Nov 22;31(47):4946-59.
REF 34 Pin1-mediated Sp1 phosphorylation by CDK1 increases Sp1 stability and decreases its DNA-binding activity during mitosis. Nucleic Acids Res. 2014 Dec 16;42(22):13573-87.
REF 35 Transcriptional regulation of neutral sphingomyelinase 2 in all-trans retinoic acid-treated human breast cancer J Biochem. 2012 Jun;151(6):599-610.
REF 36 Interplay between PKC and Sp1 on histone deacetylase inhibitor-mediated Epstein-Barr virus reactivation. J Virol. 2011 Mar;85(5):2373-85.
REF 37 Epidermal growth factor-dependent cyclooxygenase-2 induction in gliomas requires protein kinase C-delta. Oncogene. 2009 Mar 19;28(11):1410-20.
REF 38 Phosphatidylinositol 3-kinase/protein kinase Czeta-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated derepression [corrected] of transcription of the luteinizing hormone receptor gene. Mol Cell Biol. 2006 Sep;26(18):6748-61.
REF 39 Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1. Circ Res. 2008 Feb 29;102(4):e38-51.
REF 40 A novel estradiol/estrogen receptor alpha-dependent transcriptional mechanism controls expression of the human prolactin receptor. J Biol Chem. 2006 Jul 7;281(27):18825-36.
REF 41 17beta-estradiol induces IL-1alpha gene expression in rheumatoid fibroblast-like synovial cells through estrogen receptor alpha (ERalpha) and augmentation of transcriptional activity of Sp1 by dissociating histone deacetylase 2 from ERalpha. J Immunol. 2007 Mar 1;178(5):3059-66.
REF 42 Estrogen regulates KiSS1 gene expression through estrogen receptor alpha and SP protein complexes. Endocrinology. 2007 Oct;148(10):4821-8.
REF 43 Selective activation of trophoblast-specific PLAC1 in breast cancer by CCAAT/enhancer-binding protein beta (C/EBPbeta) isoform 2. J Biol Chem. 2009 Oct 16;284(42):28607-15.
REF 44 Differential intranuclear organization of transcription factors Sp1 and Sp3. Mol Biol Cell. 2005 Sep;16(9):4073-83.
REF 45 Receptor-interacting protein 140 differentially regulates estrogen receptor-related receptor transactivation depending on target genes. Mol Endocrinol. 2006 May;20(5):1035-47.
REF 46 Differential regulation of the human progesterone receptor gene through an estrogen response element half site and Sp1 sites. J Steroid Biochem Mol Biol. 2004 Feb;88(2):113-22.
REF 47 Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements. J Biol Chem. 2000 Feb 25;275(8):5379-87.
REF 48 Molecular basis of estrogen-induced cyclooxygenase type 1 upregulation in endothelial cells. Circ Res. 2005 Mar 18;96(5):518-25.
REF 49 Retinoic acid (RA) regulates 17beta-hydroxysteroid dehydrogenase type 2 expression in endometrium: interaction of RA receptors with specificity protein (SP) 1/SP3 for estradiol metabolism. J Clin Endocrinol Metab. 2008 May;93(5):1915-23.
REF 50 Retinoic acid activates monoamine oxidase B promoter in human neuronal cells. J Biol Chem. 2009 Jun 19;284(25):16723-35.
REF 51 Transcription of human resistin gene involves an interaction of Sp1 with peroxisome proliferator-activating receptor gamma (PPARgamma). PLoS One. 2010 Mar 29;5(3):e9912.
REF 52 The insulin receptor: a new anticancer target for peroxisome proliferator-activated receptor-gamma (PPARgamma) and thiazolidinedione-PPARgamma agonists. Endocr Relat Cancer. 2008 Mar;15(1):325-35.
REF 53 Transcriptional regulation of human eosinophil RNase2 by the liver-enriched hepatocyte nuclear factor 4. J Cell Biochem. 2009 Feb 1;106(2):317-26.
REF 54 Negative autoregulation of HNF-4alpha gene expression by HNF-4alpha1. Biochem J. 2005 May 15;388(Pt 1):325-32.
REF 55 Tumor suppressor p53 represses transcription of RECQ4 helicase. Oncogene. 2005 Mar 3;24(10):1738-48.
REF 56 Cooperative actions of HIV-1 Vpr and p53 modulate viral gene transcription. J Biol Chem. 1998 Aug 7;273(32):20052-7.
REF 57 p53 is a NF-Y- and p21-independent, Sp1-dependent repressor of cyclin B1 transcription. FEBS Lett. 2005 Feb 14;579(5):1001-7.
REF 58 p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1. Endocrinology. 1998 Mar;139(3):1101-7.
REF 59 DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter. Mol Cell. 2004 Dec 3;16(5):725-36.
REF 60 p53-Mediated down-regulation of the human DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) via interaction with Sp1 transcription factor. Anticancer Res. 2009 Oct;29(10):3741-50.
REF 61 Sp1 family of transcription factors regulates the human alpha2 (XI) collagen gene (COL11A2) in Saos-2 osteoblastic cells. J Bone Miner Res. 2006 May;21(5):661-73.
REF 62 The identification of trans-acting factors that regulate the expression of GDF5 via the osteoarthritis susceptibility SNP rs143383. PLoS Genet. 2013 Jun;9(6):e1003557.
REF 63 Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium. Implications for the mechanisms of aortic aneurysm and heart failure. J Biol Chem. 2000 Aug 11;275(32):24583-9.
REF 64 ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3alpha gene expression in Caco-2 human colonic epithelial cells. J Biol Chem. 2003 Jan 10;278(2):875-84.
REF 65 Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal human prostate epithelial cells. Oncogene. 2004 Sep 9;23(41):6942-53.
REF 66 Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways. J Biol Chem. 2002 Nov 15;277(46):43799-808.
REF 67 Identification of a critical Sp1 site within the endoglin promoter and its involvement in the transforming growth factor-beta stimulation. J Biol Chem. 2001 Sep 14;276(37):34486-94.
REF 68 Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta. J Biol Chem. 2000 Sep 22;275(38):29244-56.
REF 69 Histone deacetylase inhibitors upregulate MMP11 gene expression through Sp1/Smad complexes in human colon adenocarcinoma cells. Biochim Biophys Acta. 2012 Feb;1823(2):570-81.
REF 70 The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression. EMBO J. 2006 Oct 18;25(20):4784-94.
REF 71 HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression. Mol Cell. 2005 Mar 18;17(6):793-803.
REF 72 O-GlcNAc modification of Sp1 inhibits the functional interaction between Sp1 and Oct1. FEBS Lett. 2009 Feb 4;583(3):512-20.
REF 73 The transcription factors Sp1 and Oct-1 interact physically to regulate human U2 snRNA gene expression. Nucleic Acids Res. 1996 Jun 1;24(11):1981-6.
REF 74 A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening. Mol Cell Biochem. 2000 Jul;210(1-2):131-42.
REF 75 Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3. Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4510-5.
REF 76 HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell. 2007 Apr;11(4):335-47.
REF 77 NF-kappaB induced by IL-1beta inhibits elastin transcription and myofibroblast phenotype. Am J Physiol Cell Physiol. 2002 Jul;283(1):C58-65.
REF 78 Endothelin-1 induces glut1 transcription through enhanced interaction between Sp1 and NF-kappaB transcription factors. Cell Signal. 2008 Apr;20(4):771-8.
REF 79 NF-kappaB activation limits airway branching through inhibition of Sp1-mediated fibroblast growth factor-10 expression. J Immunol. 2010 Oct 15;185(8):4896-903.
REF 80 Interaction of the v-Rel oncoprotein with cellular transcription factor Sp1. J Virol. 1994 Nov;68(11):7131-8.
REF 81 Interaction between the two ubiquitously expressed transcription factors NF-Y and Sp1. Gene. 1999 Jun 24;234(1):61-9.
REF 82 Transcriptional activation of E2F1 gene expression by 17beta-estradiol in MCF-7 cells is regulated by NF-Y-Sp1/estrogen receptor interactions. Mol Endocrinol. 1999 Aug;13(8):1373-87.
REF 83 TGF-1 downregulates AT1 receptor expression via PKC--mediated Sp1 dissociation from KLF4 and Smad-mediated PPAR- association with KLF4. Arterioscler Thromb Vasc Biol. 2012 Apr;32(4):1015-23.
REF 84 The gut-enriched Krpel-like factor suppresses the activity of the CYP1A1 promoter in an Sp1-dependent fashion. J Biol Chem. 1998 Jul 10;273(28):17917-25.
REF 85 PP2B-mediated dephosphorylation of c-Jun C terminus regulates phorbol ester-induced c-Jun/Sp1 interaction in A431 cells. Mol Biol Cell. 2007 Mar;18(3):1118-27.
REF 86 c-Jun transactivates the promoter of the human p21(WAF1/Cip1) gene by acting as a superactivator of the ubiquitous transcription factor Sp1. J Biol Chem. 1999 Oct 8;274(41):29572-81.
REF 87 MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity. J Biol Chem. 2009 Feb 20;284(8):5165-74.
REF 88 Activation of Sp1-mediated transcription by Rta of Epstein-Barr virus via an interaction with MCAF1. Nucleic Acids Res. 2005 Nov 28;33(20):6528-39.
REF 89 Growth-dependent repression of human adenine nucleotide translocator-2 (ANT2) transcription: evidence for the participation of Smad and Sp family proteins in the NF1-dependent repressor complex. Biochem J. 2008 May 15;412(1):123-30.
REF 90 Transcriptional coactivator CBP upregulates hTERT expression and tumor growth and predicts poor prognosis in human lung cancers. Oncotarget. 2014 Oct 15;5(19):9349-61.
REF 91 Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction. Mol Cell Biol. 1996 Apr;16(4):1668-75.
REF 92 A nucleoprotein complex containing Sp1, C/EBP beta, and HMGI-Y controls human insulin receptor gene transcription. Mol Cell Biol. 2003 Apr;23(8):2720-32.
REF 93 Composite co-activator ARC mediates chromatin-directed transcriptional activation. Nature. 1999 Apr 29;398(6730):828-32.
REF 94 Co-stimulation of promoter for low density lipoprotein receptor gene by sterol regulatory element-binding protein and Sp1 is specifically disrupted by the yin yang 1 protein. J Biol Chem. 1999 May 7;274(19):13025-32.
REF 95 Modulation of IFN- receptor 1 expression by AP-2 influences IFN- sensitivity of cancer cells. Am J Pathol. 2012 Feb;180(2):661-71.
REF 96 Dynamic transcriptional regulatory complexes including BORIS, CTCF and Sp1 modulate NY-ESO-1 expression in lung cancer cells. Oncogene. 2007 Jun 28;26(30):4394-403.
REF 97 Differential regulation of MAGE-A1 promoter activity by BORIS and Sp1, both interacting with the TATA binding protein. BMC Cancer. 2014 Nov 3;14:796.
REF 98 GATA6 promotes colon cancer cell invasion by regulating urokinase plasminogen activator gene expression. Neoplasia. 2010 Nov;12(11):856-65.
REF 99 GATA-4 and GATA-6 modulate tissue-specific transcription of the human gene for P450c17 by direct interaction with Sp1. Mol Endocrinol. 2004 May;18(5):1144-57.
REF 100 A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2. Mol Cell. 1998 Dec;2(6):751-9.
REF 101 Interaction of Sp1 transcription factor with HIV-1 Tat protein: looking for cellular partners. FEBS Lett. 2003 May 22;543(1-3):61-5.
REF 102 Regulation of Transcription Factor SP1 by the -Catenin Destruction Complex Modulates Wnt Response. Mol Cell Biol. 2018 Oct 29;38(22). pii: e00188-18.

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