Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T25956 Target Info
Target Name Histone acetyltransferase p300 (EP300)
Synonyms p300 HAT; Protein propionyltransferase p300; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1Aassociated protein p300; E1A-associated protein p300
Target Type Clinical trial Target
Gene Name EP300
Biochemical Class Acyltransferase
UniProt ID
EP300_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 4 Acid anhydride hydrolases +
Interacting Target Name ATP-dependent RNA helicase DDX5 (DDX5) Clinical trial Target Interacting Protein Info
UniProt ID
DDX5_HUMAN 
Synonyms RNA helicase p68; Probable ATP-dependent RNA helicase DDX5; HLR1; HELR; G17P1; DEAD box protein 5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [2]
Interacting Protein Name Probable ATP-dependent RNA helicase DDX17 (DDX17) Interacting Protein Interacting Protein Info
UniProt ID
DDX17_HUMAN 
Synonyms P72; RH70
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Biochemical Activity [2]
Interacting Protein Name ATP-dependent RNA helicase DDX24 (DDX24) Interacting Protein Interacting Protein Info
UniProt ID
DDX24_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [5]
Interacting Protein Name DNA repair protein RAD50 (RAD50) Interacting Protein Interacting Protein Info
UniProt ID
RAD50_HUMAN 
Synonyms NBSLD; RAD502; hRad50
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Reconstituted Complex [6]
Acyltransferases [+] 3 Acyltransferases +
Interacting Target Name Histone acetyltransferase KAT2B (KAT2B) Literature-reported Target Interacting Protein Info
UniProt ID
KAT2B_HUMAN 
Synonyms Spermidine acetyltransferase KAT2B; PCAF; P300/CBP-associated factor; P/CAF; Lysine acetyltransferase 2B; Histone acetyltransferase PCAF; Histone acetylase PCAF
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [9]
4 Biochemical Activity [10]
5 Biochemical Activity [11]
6 Biochemical Activity [12]
7 Reconstituted Complex [8]
Interacting Protein Name Breast cancer type 1 susceptibility protein (BRCA1) Interacting Protein Interacting Protein Info
UniProt ID
BRCA1_HUMAN 
Synonyms BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Affinity Capture-Western [14]
3 Affinity Capture-Western [15]
4 Reconstituted Complex [13]
Interacting Target Name Nuclear receptor coactivator 3 (NCOA3) Literature-reported Target Interacting Protein Info
UniProt ID
NCOA3_HUMAN 
Synonyms TRAM-1; TRAM1; Thyroid hormone receptor activator molecule 1; Steroid receptor coactivator protein 3; SRC-3; Receptor-associated coactivator 3; RAC-3; RAC3; PCIP; NCoA-3; Class E basic helix-loop-helix protein 42; CBP-interacting protein; bHLHe42; Amplified in breast cancer-1 protein; Amplified in breast cancer 1 protein; AIB1 (SRC-3); AIB-1; AIB1; ACTR
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Affinity Capture-Western [17]
3 Biochemical Activity [18]
Carbon-nitrogen hydrolases [+] 4 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Affinity Capture-Western [20]
3 Biochemical Activity [21]
4 Reconstituted Complex [22]
Interacting Target Name Histone deacetylase 6 (HDAC6) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC6_HUMAN 
Synonyms KIAA0901; JM21; HD6
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [23]
2 Affinity Capture-Western [24]
3 Biochemical Activity [21]
4 Reconstituted Complex [25]
Interacting Target Name Histone deacetylase 3 (HDAC3) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC3_HUMAN 
Synonyms SMAP45; RPD3-2; RPD32; HD3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [26]
2 Affinity Capture-Western [27]
3 Reconstituted Complex [28]
Interacting Target Name NAD-dependent deacetylase sirtuin-2 (SIRT2) Patented-recorded Target Interacting Protein Info
UniProt ID
SIR2_HUMAN 
Synonyms SIR2-like protein 2; SIR2like protein 2; SIR2L2; SIR2L; Regulatory protein SIR2 homolog 2; NAD-dependent protein deacetylase sirtuin-2; NADdependent protein deacetylase sirtuin2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Biochemical Activity [29]
Cell cycle related proteins [+] 1 Cell cycle related proteins +
Interacting Target Name G1/S-specific cyclin-D1 (CCND1) Clinical trial Target Interacting Protein Info
UniProt ID
CCND1_HUMAN 
Synonyms PRAD1 oncogene; PRAD1; Cyclin D1; BCL-1 oncogene; BCL-1; BCL1; B-cell lymphoma 1 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [30]
2 Reconstituted Complex [31]
Cell division cycle proteins [+] 1 Cell division cycle proteins +
Interacting Protein Name Retinoblastoma-associated protein (RB1) Interacting Protein Interacting Protein Info
UniProt ID
RB_HUMAN 
Synonyms OSRC; PPP1R130; RB; p105.Rb; pRb; pp110
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [32]
2 Biochemical Activity [33]
Ester hydrolases [+] 2 Ester hydrolases +
Interacting Target Name AP endonuclease 1 (APEX1) Clinical trial Target Interacting Protein Info
UniProt ID
APEX1_HUMAN 
Synonyms REF-1 protein; Apurinic/apyrimidinic endonuclease/redox factor-1; APEX1; APEX nuclease; APEN; APE/ref-1; AP endonuclease 1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Biochemical Activity [35]
3 Biochemical Activity [36]
4 Reconstituted Complex [34]
5 Reconstituted Complex [6]
Interacting Protein Name Flap endonuclease 1 (FEN1) Interacting Protein Interacting Protein Info
UniProt ID
FEN1_HUMAN 
Synonyms FEN.1; MF1; RAD2
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [37]
2 Affinity Capture-Western [38]
3 Biochemical Activity [37]
4 Biochemical Activity [39]
5 Reconstituted Complex [37]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Lipopolysaccharide-associated protein 1 (HSPA8) Literature-reported Target Interacting Protein Info
UniProt ID
HSP7C_HUMAN 
Synonyms LPS-associated protein 1; LAP-1; HSPA10; HSP73; HSC70; Heat shock protein 73; Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [40]
2 Affinity Capture-Western [41]
Histones [+] 4 Histones +
Interacting Protein Name Histone H3.1 (H31) Interacting Protein Interacting Protein Info
UniProt ID
H31_HUMAN 
Synonyms H3/A; H3FA
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-Western [41]
2 Biochemical Activity [42]
3 Biochemical Activity [43]
4 Biochemical Activity [30]
5 Biochemical Activity [44]
6 Biochemical Activity [45]
7 Biochemical Activity [46]
8 Biochemical Activity [47]
9 Biochemical Activity [48]
10 Biochemical Activity [49]
11 Biochemical Activity [50]
12 Biochemical Activity [51]
13 Biochemical Activity [52]
14 Biochemical Activity [53]
15 Biochemical Activity [54]
16 Biochemical Activity [55]
17 Biochemical Activity [56]
18 Biochemical Activity [57]
19 Biochemical Activity [58]
20 Biochemical Activity [59]
Interacting Protein Name Histone H4 (H4) Interacting Protein Interacting Protein Info
UniProt ID
H4_HUMAN 
Synonyms H4FA
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-Western [41]
2 Biochemical Activity [51]
3 Biochemical Activity [60]
4 Biochemical Activity [43]
5 Biochemical Activity [30]
6 Biochemical Activity [48]
7 Biochemical Activity [49]
8 Biochemical Activity [50]
9 Biochemical Activity [52]
10 Biochemical Activity [53]
11 Biochemical Activity [54]
12 Biochemical Activity [56]
13 Biochemical Activity [57]
14 Biochemical Activity [59]
15 Biochemical Activity [61]
16 Biochemical Activity [62]
17 Biochemical Activity [63]
18 Biochemical Activity [64]
19 Biochemical Activity [65]
20 Biochemical Activity [66]
Interacting Protein Name Histone H2A type 1-B/E (H2AFM/A) Interacting Protein Interacting Protein Info
UniProt ID
H2A1B_HUMAN 
Synonyms H2A/m; H2AFM
Evidence Score (E-score) 8 Experimental Evidences +
1 Biochemical Activity [51]
2 Biochemical Activity [30]
3 Biochemical Activity [49]
4 Biochemical Activity [50]
5 Biochemical Activity [52]
6 Biochemical Activity [53]
7 Biochemical Activity [54]
8 Reconstituted Complex [47]
Interacting Protein Name Histone H2B type 1-B (HIST1H2BB) Interacting Protein Interacting Protein Info
UniProt ID
H2B1B_HUMAN 
Synonyms H2B.1; H2B/f; H2BFF
Evidence Score (E-score) 8 Experimental Evidences +
1 Biochemical Activity [51]
2 Biochemical Activity [30]
3 Biochemical Activity [49]
4 Biochemical Activity [50]
5 Biochemical Activity [52]
6 Biochemical Activity [53]
7 Biochemical Activity [54]
8 Reconstituted Complex [47]
Kinases [+] 2 Kinases +
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [67]
2 Affinity Capture-Western [68]
3 Biochemical Activity [69]
4 Reconstituted Complex [70]
Interacting Target Name Stress-activated protein kinase 2a (p38 alpha) Clinical trial Target Interacting Protein Info
UniProt ID
MK14_HUMAN 
Synonyms SAPK2A; P38 Mitogen-activatedprotein kinase alpha; P38 mitogen activatedprotein kinase; MXI2; Mitogen-activated protein kinase p38 alpha; Mitogen-activated protein kinase 14; MAX-interacting protein 2; MAPK 14; MAP kinase p38alpha; MAP kinase p38 alpha; MAP kinase MXI2; MAP kinase 14; Cytokine suppressive anti-inflammatory drug-binding protein; Cytokine suppressive anti-inflammatory drug binding protein; CSPB1; CSBP2; CSBP1; CSBP; CSAID-binding protein; CSAID binding protein; CRK1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [71]
2 Biochemical Activity [72]
Nuclear hormone receptors [+] 6 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-Western [73]
2 Affinity Capture-Western [74]
3 Affinity Capture-Western [75]
4 Affinity Capture-Western [76]
5 Affinity Capture-Western [77]
6 Biochemical Activity [78]
7 Biochemical Activity [79]
8 Biochemical Activity [80]
9 Biochemical Activity [48]
10 Reconstituted Complex [81]
Interacting Target Name Peroxisome proliferator-activated receptor gamma (PPAR-gamma) Successful Target Interacting Protein Info
UniProt ID
PPARG_HUMAN 
Synonyms Transcription factor PPAR gamma receptor; PPAR-gamma; PPARgamma; Peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3; NR1C3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [82]
2 Affinity Capture-Western [15]
3 Reconstituted Complex [81]
4 Reconstituted Complex [83]
Interacting Target Name Androgen receptor (AR) Successful Target Interacting Protein Info
UniProt ID
ANDR_HUMAN 
Synonyms Testosterone receptor; Nuclear receptor subfamily 3 group C member 4; NR3C4; Dihydrotestosterone receptor; DHTR; Androgen receptor
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [84]
2 Biochemical Activity [85]
Interacting Target Name Estrogen receptor beta (ESR2) Successful Target Interacting Protein Info
UniProt ID
ESR2_HUMAN 
Synonyms Oestrogen receptor beta; Nuclear receptor subfamily 3 group A member 2; NR3A2; ESTRB; ER-beta; Erbeta; Beta-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [86]
2 Fluorescence Resonance Energy Transfer [87]
Interacting Target Name Peroxisome proliferator-activated receptor alpha (PPARA) Successful Target Interacting Protein Info
UniProt ID
PPARA_HUMAN 
Synonyms PPAR-alpha; PPARalpha; PPAR; Peroxisome proliferater-activated receptor alpha; Nuclear receptor subfamily 1 group C member 1; NR1C1
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [88]
2 Yeast two hybrid [89]
Interacting Target Name Peroxisome proliferator-activated receptor delta (PPARD) Clinical trial Target Interacting Protein Info
UniProt ID
PPARD_HUMAN 
Synonyms PPAR-delta; PPARdelta; PPAR-beta; PPARB; Peroxisomeproliferator-activated receptor beta; Peroxisomeproliferator activated receptor beta/delta; Peroxisome proliferator-activated receptor beta; Nuclear receptor subfamily 1 group C member 2; Nuclear hormone receptor 1; NUCI; NUC1; NR1C2
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [90]
2 Yeast two hybrid [91]
One-carbon transferases [+] 2 One-carbon transferases +
Interacting Target Name Histone-arginine methyltransferase CARM1 (CARM1) Literature-reported Target Interacting Protein Info
UniProt ID
CARM1_HUMAN 
Synonyms Protein arginine N-methyltransferase 4; PRMT4; Histonearginine methyltransferase CARM1; Coactivator-associated arginine methyltransferase 1; Coactivatorassociated arginine methyltransferase 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [92]
2 Affinity Capture-Western [43]
3 Reconstituted Complex [93]
Interacting Target Name Protein arginine methyltransferase 1 (PRMT1) Clinical trial Target Interacting Protein Info
UniProt ID
ANM1_HUMAN 
Synonyms Protein arginine N-methyltransferase 1; IR1B4; Interferon receptor 1-bound protein 4; HRMT1L2; HMT2; Histone-arginine N-methyltransferase PRMT1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [92]
2 Biochemical Activity [94]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-Luminescence [95]
2 Affinity Capture-Western [95]
3 Affinity Capture-Western [96]
4 Affinity Capture-Western [97]
5 Affinity Capture-Western [5]
6 Affinity Capture-Western [20]
7 Affinity Capture-Western [98]
8 Affinity Capture-Western [99]
9 Affinity Capture-Western [100]
10 Affinity Capture-Western [101]
11 Affinity Capture-Western [102]
12 Affinity Capture-Western [103]
13 Affinity Capture-Western [104]
14 Affinity Capture-Western [105]
15 Affinity Capture-Western [106]
16 Affinity Capture-Western [107]
17 Affinity Capture-Western [108]
18 Affinity Capture-Western [109]
19 Affinity Capture-Western [110]
20 Affinity Capture-Western [111]
Transcription regulators [+] 47 Transcription regulators +
Interacting Target Name Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Interacting Protein Info
UniProt ID
HIF1A_HUMAN 
Synonyms Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-Western [112]
2 Affinity Capture-Western [113]
3 Affinity Capture-Western [114]
4 Affinity Capture-Western [115]
5 Affinity Capture-Western [116]
6 Affinity Capture-Western [98]
7 Affinity Capture-Western [117]
8 Affinity Capture-Western [118]
9 Affinity Capture-Western [119]
10 Affinity Capture-Western [120]
11 Affinity Capture-Western [121]
12 Affinity Capture-Western [122]
13 Affinity Capture-Western [123]
14 Affinity Capture-Western [124]
15 Affinity Capture-Western [125]
16 Affinity Capture-Western [126]
17 Affinity Capture-Western [127]
18 Biochemical Activity [128]
19 Co-crystal Structure [129]
20 Fluorescence Resonance Energy Transfer [130]
Interacting Protein Name Transcription factor p65 (RELA) Interacting Protein Interacting Protein Info
UniProt ID
TF65_HUMAN 
Synonyms NFKB3; p65
Evidence Score (E-score) 17 Experimental Evidences +
1 Affinity Capture-Western [131]
2 Affinity Capture-Western [92]
3 Affinity Capture-Western [67]
4 Affinity Capture-Western [120]
5 Affinity Capture-Western [71]
6 Affinity Capture-Western [132]
7 Affinity Capture-Western [133]
8 Affinity Capture-Western [134]
9 Affinity Capture-Western [135]
10 Affinity Capture-Western [136]
11 Affinity Capture-Western [137]
12 Affinity Capture-Western [138]
13 Biochemical Activity [10]
14 Biochemical Activity [138]
15 Reconstituted Complex [131]
16 Reconstituted Complex [132]
17 Yeast two hybrid [131]
Interacting Target Name Mothers against decapentaplegic homolog 3 (SMAD3) Successful Target Interacting Protein Info
UniProt ID
SMAD3_HUMAN 
Synonyms TGF-beta response effector Smad3; Smad3; SMAD family member 3; SMAD 3; Mothers against DPP homolog 3; MMad3; MADH3; Mad3; MAD homolog 3; JV15-2; HSMAD3; HMAD-3
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-Western [139]
2 Affinity Capture-Western [140]
3 Affinity Capture-Western [141]
4 Affinity Capture-Western [142]
5 Affinity Capture-Western [143]
6 Affinity Capture-Western [144]
7 Affinity Capture-Western [145]
8 Affinity Capture-Western [146]
9 Affinity Capture-Western [147]
10 Affinity Capture-Western [148]
11 Reconstituted Complex [143]
12 Yeast two hybrid [140]
Interacting Target Name Transcription factor Sp1 (SP1) Clinical trial Target Interacting Protein Info
UniProt ID
SP1_HUMAN 
Synonyms TSFP1
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-Western [149]
2 Affinity Capture-Western [150]
3 Affinity Capture-Western [151]
4 Affinity Capture-Western [152]
5 Affinity Capture-Western [153]
6 Affinity Capture-Western [154]
7 Biochemical Activity [155]
8 Biochemical Activity [156]
9 Co-localization [151]
10 Co-localization [152]
11 Co-localization [154]
12 Reconstituted Complex [156]
Interacting Target Name Transcription factor AP-1 (JUN) Discontinued Target Interacting Protein Info
UniProt ID
JUN_HUMAN 
Synonyms V-jun avian sarcoma virus 17 oncogene homolog; Transcription factor AP-1; Proto-oncogene c-jun; P39; C-jun proto-oncogene; AP-1 transcription factor; AP1; Activator protein-1; Activator protein 1
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-Western [157]
2 Affinity Capture-Western [158]
3 Affinity Capture-Western [159]
4 Affinity Capture-Western [160]
5 Biochemical Activity [161]
6 Biochemical Activity [162]
7 Co-crystal Structure [163]
8 Co-fractionation [163]
9 Co-localization [164]
10 Reconstituted Complex [163]
Interacting Target Name Signal transducer and activator of transcription 3 (STAT3) Successful Target Interacting Protein Info
UniProt ID
STAT3_HUMAN 
Synonyms Transcription factor STAT3; Stat3; Signal transducer and activator of transcription 3; APRF; Acute-phase response factor
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-Western [165]
2 Affinity Capture-Western [166]
3 Affinity Capture-Western [167]
4 Affinity Capture-Western [168]
5 Affinity Capture-Western [169]
6 Affinity Capture-Western [170]
7 Affinity Capture-Western [171]
8 Biochemical Activity [166]
9 Biochemical Activity [172]
Interacting Target Name Cyclic AMP-responsive element-binding protein (CREB1) Literature-reported Target Interacting Protein Info
UniProt ID
CREB1_HUMAN 
Synonyms Cyclic AMP-responsive element-binding protein 1; Cyclic AMP responseelement-binding protein; CREB-1; CREB; cAMP-responsive element-binding protein 1; CAMP-response element binding protein
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Affinity Capture-Western [173]
3 Affinity Capture-Western [15]
4 Affinity Capture-Western [174]
5 Co-localization [174]
6 Far Western [175]
7 Reconstituted Complex [176]
8 Reconstituted Complex [175]
Interacting Protein Name Cbp/p300-interacting transactivator 2 (CITED2) Interacting Protein Interacting Protein Info
UniProt ID
CITE2_HUMAN 
Synonyms ASD8; MRG.1; MRG1; P35SRJ; VSD2
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [177]
2 Affinity Capture-Western [178]
3 Reconstituted Complex [179]
4 Reconstituted Complex [180]
5 Reconstituted Complex [181]
6 Yeast two hybrid [180]
7 Yeast two hybrid [178]
Interacting Protein Name Tumor protein 63 (TP63) Interacting Protein Interacting Protein Info
UniProt ID
P63_HUMAN 
Synonyms AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; RHS; SHFM4; TP53CP; TP53L; TP73L; p40; p51; p53CP; p63; p73H; p73L
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [182]
2 Affinity Capture-Western [183]
3 Affinity Capture-Western [184]
4 Biochemical Activity [184]
5 Biochemical Activity [183]
6 Reconstituted Complex [183]
Interacting Protein Name Transcriptional repressor protein YY1 (YY1) Interacting Protein Interacting Protein Info
UniProt ID
TYY1_HUMAN 
Synonyms DELTA; INO80S; NF.E1; UCRBP; YIN.YANG.1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [185]
2 Affinity Capture-Western [186]
3 Affinity Capture-Western [26]
4 Affinity Capture-Western [27]
5 Biochemical Activity [187]
6 Reconstituted Complex [185]
Interacting Target Name DNA-binding factor KBF1 (p105) Clinical trial Target Interacting Protein Info
UniProt ID
NFKB1_HUMAN 
Synonyms Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; Nuclear factor of kappa light polypeptide gene enhancer in Bcells 1; Nuclear factor NFkappaB p50 subunit; Nuclear factor NF-kappa-B p105 subunit; Nuclear factor NFkappaB p105 subunit; EBP-1; EBP1; DNA-binding factor KBF1; DNAbinding factor KBF1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [188]
2 Affinity Capture-Western [189]
3 Affinity Capture-Western [132]
4 Biochemical Activity [190]
5 Reconstituted Complex [132]
Interacting Target Name Forkhead box protein O1A (FOXO1) Literature-reported Target Interacting Protein Info
UniProt ID
FOXO1_HUMAN 
Synonyms FOXO1A; Forkhead in rhabdomyosarcoma; Forkhead box protein O1A; Forkhead box protein O1; FKHR
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [191]
2 Affinity Capture-Western [192]
3 Biochemical Activity [193]
4 Biochemical Activity [191]
5 Biochemical Activity [194]
Interacting Target Name Early growth response protein 1 (EGR-1) Clinical trial Target Interacting Protein Info
UniProt ID
EGR1_HUMAN 
Synonyms ZNF225; Zinc finger protein Krox-24; Zinc finger protein Krox24; Zinc finger protein 225; Transcription factor Zif268; Transcription factor ETR103; NGFI-A; NGFIA; Nerve growth factor-induced protein A; Nerve growth factorinduced protein A; KROX24; AT225
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [195]
2 Reconstituted Complex [195]
3 Reconstituted Complex [196]
4 Yeast two hybrid [195]
Interacting Target Name CCAAT/enhancer binding protein beta (CEBPB) Literature-reported Target Interacting Protein Info
UniProt ID
CEBPB_HUMAN 
Synonyms Transcription factor CCAAT/enhancer-binding protein beta; Transcription factor 5; TCF-5; TCF5; PP9092; Nuclear factor NF-IL6; Liver-enriched inhibitory protein; Liver activator protein; LIP; LAP; CCAAT/enhancer-binding protein beta; C/EBP beta
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [197]
2 Affinity Capture-Western [198]
3 Co-localization [164]
4 Reconstituted Complex [197]
Interacting Target Name Signal transducer and activator of transcription 6 (STAT6) Literature-reported Target Interacting Protein Info
UniProt ID
STAT6_HUMAN 
Synonyms IL-4 Stat
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [199]
2 Affinity Capture-Western [200]
3 Co-localization [199]
4 Co-localization [200]
Interacting Protein Name Transcriptional activator Myb (MYB) Interacting Protein Interacting Protein Info
UniProt ID
MYB_HUMAN 
Synonyms Transcriptional activator Myb; Proto-oncogene c-Myb
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [201]
2 Affinity Capture-Western [202]
3 Biochemical Activity [203]
4 Reconstituted Complex [204]
Interacting Protein Name Nuclear transcription factor Y subunit beta (NFYB) Interacting Protein Interacting Protein Info
UniProt ID
NFYB_HUMAN 
Synonyms CBF.A; CBF.B; HAP3; NF.YB
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [205]
2 Affinity Capture-Western [206]
3 Biochemical Activity [207]
4 Reconstituted Complex [206]
Interacting Protein Name Tumor protein p73 (TP73) Interacting Protein Interacting Protein Info
UniProt ID
P73_HUMAN 
Synonyms P73
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [208]
2 Biochemical Activity [209]
3 Co-purification [208]
4 Reconstituted Complex [208]
Interacting Protein Name Mothers against decapentaplegic homolog 4 (SMAD4) Interacting Protein Interacting Protein Info
UniProt ID
SMAD4_HUMAN 
Synonyms DPC4; JIP; MADH4; MYHRS
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [210]
2 Affinity Capture-Western [211]
3 Protein-peptide [99]
4 Reconstituted Complex [143]
Interacting Protein Name Mothers against decapentaplegic homolog 2 (SMAD2) Interacting Protein Interacting Protein Info
UniProt ID
SMAD2_HUMAN 
Synonyms JV18; JV18.1; MADH2; MADR2; hMAD.2; hSMAD2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [212]
2 Affinity Capture-Western [65]
3 Affinity Capture-Western [141]
4 Yeast two hybrid [213]
Interacting Protein Name Signal transducer and activator of transcription 5A (STA5A) Interacting Protein Interacting Protein Info
UniProt ID
STA5A_HUMAN 
Synonyms MGF; STAT5
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [214]
2 Affinity Capture-Western [171]
3 Reconstituted Complex [214]
4 Yeast two hybrid [214]
Interacting Target Name Hepatocyte nuclear factor 1-alpha (HNF1A) Clinical trial Target Interacting Protein Info
UniProt ID
HNF1A_HUMAN 
Synonyms Transcription factor-1; Transcription factor 1; TCF-1; TCF1; Liver-specific transcription factor LF-B1; Liver specific transcription factor LF-B1; LFB1; HNF-1-alpha; HNF-1A; HNF-1 alpha
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [215]
2 Affinity Capture-Western [216]
3 Reconstituted Complex [215]
Interacting Target Name Notch-1 receptor (NOTCH1) Clinical trial Target Interacting Protein Info
UniProt ID
NOTC1_HUMAN 
Synonyms Translocation-associated notch protein TAN-1; Translocationassociated notch protein TAN1; TAN1; Notch 1 intracellular domain; Notch 1; NICD; Neurogenic locus notch homolog protein 1; hN1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [74]
2 Biochemical Activity [217]
3 Yeast two hybrid [217]
Interacting Target Name Kruppel like factor 4 (KLF4) Clinical trial Target Interacting Protein Info
UniProt ID
KLF4_HUMAN 
Synonyms Krueppel-like factor 4; Krueppellike factor 4; Gut-enriched krueppel-like factor; Gutenriched krueppellike factor; GKLF; EZF; Epithelial zinc finger protein EZF
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [218]
2 Co-localization [219]
3 Reconstituted Complex [220]
Interacting Target Name Proto-oncogene c-Myc (MYC) Literature-reported Target Interacting Protein Info
UniProt ID
MYC_HUMAN 
Synonyms Transcription factor p64; Proto-oncogene c-Myc; Myc proto-oncogene protein; C-myc oncogene; C-myc; Class E basic helix-loop-helix protein 39; bHLHe39
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [57]
2 Biochemical Activity [221]
3 Biochemical Activity [57]
Interacting Target Name Interferon regulatory factor 3 (IRF3) Literature-reported Target Interacting Protein Info
UniProt ID
IRF3_HUMAN 
Synonyms IRF-3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [222]
2 Biochemical Activity [223]
3 Reconstituted Complex [224]
Interacting Target Name AP-2 transcription factor (TFAP2A) Literature-reported Target Interacting Protein Info
UniProt ID
AP2A_HUMAN 
Synonyms Transcription factor AP-2-alpha; TFAP2; AP2TF; AP2-alpha; AP-2; Activator protein 2; Activating enhancer-binding protein 2-alpha
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [178]
2 Affinity Capture-Western [225]
3 Yeast two hybrid [178]
Interacting Protein Name Cbp/p300-interacting transactivator 1 (CITED1) Interacting Protein Interacting Protein Info
UniProt ID
CITE1_HUMAN 
Synonyms MSG1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [226]
2 Affinity Capture-Western [227]
3 Reconstituted Complex [226]
Interacting Protein Name ETS translocation variant 1 (ETV1) Interacting Protein Interacting Protein Info
UniProt ID
ETV1_HUMAN 
Synonyms ER81
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [228]
2 Biochemical Activity [228]
3 Biochemical Activity [229]
Interacting Protein Name Forkhead box protein P3 (FOXP3) Interacting Protein Interacting Protein Info
UniProt ID
FOXP3_HUMAN 
Synonyms AIID; DIETER; IPEX; PIDX; XPID
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [230]
2 Affinity Capture-Western [231]
3 Biochemical Activity [230]
Interacting Protein Name Transcription factor jun-B (JUNB) Interacting Protein Interacting Protein Info
UniProt ID
JUNB_HUMAN 
Synonyms AP.1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [232]
2 Biochemical Activity [161]
3 Reconstituted Complex [232]
Interacting Protein Name Krueppel-like factor 2 (KLF2) Interacting Protein Interacting Protein Info
UniProt ID
KLF2_HUMAN 
Synonyms LKLF
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [233]
2 Co-localization [219]
3 Reconstituted Complex [233]
Interacting Protein Name Myoblast determination protein 1 (MYOD1) Interacting Protein Interacting Protein Info
UniProt ID
MYOD1_HUMAN 
Synonyms MYF3; MYOD; PUM; bHLHc1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [234]
2 Reconstituted Complex [235]
3 Reconstituted Complex [176]
Interacting Protein Name Zinc finger and BTB domain-containing protein 16 (ZBTB16) Interacting Protein Interacting Protein Info
UniProt ID
ZBT16_HUMAN 
Synonyms PLZF; ZNF145
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [236]
2 Affinity Capture-Western [237]
3 Biochemical Activity [236]
Interacting Protein Name Zinc finger E-box-binding homeobox 1 (ZEB1) Interacting Protein Interacting Protein Info
UniProt ID
ZEB1_HUMAN 
Synonyms AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3; TCF8; ZFHEP; ZFHX1A
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Affinity Capture-Western [145]
3 Biochemical Activity [145]
Interacting Target Name Aryl hydrocarbon receptor (AHR) Successful Target Interacting Protein Info
UniProt ID
AHR_HUMAN 
Synonyms Class E basic helix-loop-helix protein 76; Class E basic helixloophelix protein 76; bHLHe76; AhR; Ah receptor
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-purification [238]
2 Yeast two hybrid [213]
Interacting Target Name Hypoxia-inducible factor 2 alpha (HIF-2A) Successful Target Interacting Protein Info
UniProt ID
EPAS1_HUMAN 
Synonyms PASD2; PAS domain-containing protein 2; MOP2; Member of PAS protein 2; Hypoxia-inducible factor 2-alpha; HLF; HIF-2-alpha; HIF2-alpha; HIF2A; HIF-1-alpha-like factor; EPAS-1; Endothelial PAS domain-containing protein 1; Class E basic helix-loop-helix protein 73; bHLHe73; Basic-helix-loop-helix-PAS protein MOP2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [239]
2 Affinity Capture-Western [240]
Interacting Target Name Signal transducer and activator of transcription 1 (STAT1) Patented-recorded Target Interacting Protein Info
UniProt ID
STAT1_HUMAN 
Synonyms Transcription factor ISGF-3 components p91/p84; STAT-1; Signal transducers and activators of transcription factor; Signal transducer and activator of transcription 1-alpha/beta; P91
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [241]
2 Co-localization [171]
Interacting Target Name Activating transcription factor 4 (ATF-4) Literature-reported Target Interacting Protein Info
UniProt ID
ATF4_HUMAN 
Synonyms TXREB; Tax-responsive enhancer element-binding protein 67; Taxresponsive enhancer elementbinding protein 67; TaxREB67; DNA-binding protein TAXREB67; DNAbinding protein TAXREB67; Cyclic AMP-responsive element-binding protein 2; Cyclic AMPresponsive elementbinding protein 2; Cyclic AMP-dependent transcription factor ATF-4; Cyclic AMPdependent transcription factor ATF4; CREB-2; CREB2; cAMP-responsive element-binding protein 2; cAMPresponsive elementbinding protein 2; cAMP-dependent transcription factor ATF-4; cAMPdependent transcription factor ATF4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [242]
2 Co-localization [164]
Interacting Target Name Protein C-ets-1 (ETS1) Literature-reported Target Interacting Protein Info
UniProt ID
ETS1_HUMAN 
Synonyms P54; EWSR2
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-peptide [243]
2 Reconstituted Complex [244]
Interacting Target Name Sterol regulatory element binding protein-1 (SREBF1) Literature-reported Target Interacting Protein Info
UniProt ID
SRBP1_HUMAN 
Synonyms Sterol regulatory element-binding transcription factor 1; Sterol regulatory element-binding protein 1; SREBP-1; SREBP1; SREBP 1; Class D basic helix-loop-helix protein 1; bHLHd1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [245]
2 Biochemical Activity [246]
Interacting Target Name Interferon regulatory factor 1 (IRF1) Literature-reported Target Interacting Protein Info
UniProt ID
IRF1_HUMAN 
Synonyms IRF-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [188]
2 Reconstituted Complex [247]
Interacting Target Name Proto-oncogene c-Rel (REL) Literature-reported Target Interacting Protein Info
UniProt ID
REL_HUMAN 
Synonyms C-Rel
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [248]
2 Reconstituted Complex [248]
Interacting Protein Name Neurogenic differentiation factor 1 (NEUROD1) Interacting Protein Interacting Protein Info
UniProt ID
NDF1_HUMAN 
Synonyms BETA2; BHF.1; MODY6; NEUROD; bHLHa3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [249]
2 Reconstituted Complex [250]
Interacting Protein Name NFAT transcription complex cytosolic component (NFATC1) Interacting Protein Interacting Protein Info
UniProt ID
NFAC1_HUMAN 
Synonyms NF.ATC; NFAT2; NFATc
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [251]
2 Biochemical Activity [11]
Interacting Protein Name T-cell acute lymphocytic leukemia protein 1 (TAL1) Interacting Protein Interacting Protein Info
UniProt ID
TAL1_HUMAN 
Synonyms SCL; TCL5; bHLHa17; tal.1
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [252]
2 Reconstituted Complex [253]
Interacting Protein Name Nuclear receptor coactivator 2 (NCOA2) Interacting Protein Interacting Protein Info
UniProt ID
NCOA2_HUMAN 
Synonyms GRIP1; KAT13C; NCoA.2; SRC2; TIF2; bHLHe75
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [18]
2 Yeast two hybrid [254]
Ubiquitin related proteins [+] 2 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [100]
2 Biochemical Activity [255]
3 Biochemical Activity [256]
4 Co-fractionation [257]
5 Reconstituted Complex [257]
6 Reconstituted Complex [181]
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [24]
2 Biochemical Activity [47]
Other proteins [+] 7 Other proteins +
Interacting Target Name Beta-catenin (CTNNB1) Successful Target Interacting Protein Info
UniProt ID
CTNB1_HUMAN 
Synonyms Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Luminescence [258]
2 Affinity Capture-Western [258]
3 Affinity Capture-Western [259]
4 Affinity Capture-Western [260]
5 Affinity Capture-Western [261]
6 Biochemical Activity [262]
7 Reconstituted Complex [258]
8 Reconstituted Complex [263]
Interacting Target Name Proliferating cell nuclear antigen (PCNA) Clinical trial Target Interacting Protein Info
UniProt ID
PCNA_HUMAN 
Synonyms Cyclin
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [264]
2 Affinity Capture-Western [265]
3 Affinity Capture-Western [266]
4 Affinity Capture-Western [267]
5 Biochemical Activity [267]
6 Reconstituted Complex [264]
7 Reconstituted Complex [265]
8 Reconstituted Complex [266]
Interacting Target Name Poly [ADP-ribose] polymerase 1 (PARP1) Successful Target Interacting Protein Info
UniProt ID
PARP1_HUMAN 
Synonyms Protein poly-ADP-ribosyltransferase PARP1; PPOL; Poly[ADP-ribose] synthetase-1; Poly[ADP-ribose] synthase 1; Poly(ADP-ribose)polymerase-1; PARP-1; NAD(+)Poly [ADP-ribose] polymerase-1 ADP-ribosyltransferase-1; NAD(+) ADP-ribosyltransferase-1; NAD(+) ADP-ribosyltransferase 1; DNA ADP-ribosyltransferase PARP1; ARTD1; ADPRT 1; ADPRT; ADP-ribosyltransferase diphtheria toxin-like 1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [268]
2 Affinity Capture-Western [92]
3 Affinity Capture-Western [159]
4 Affinity Capture-Western [132]
5 Biochemical Activity [269]
6 Reconstituted Complex [132]
Interacting Protein Name Glutamate receptor-interacting protein 1 (GRIP1) Interacting Protein Interacting Protein Info
UniProt ID
GRIP1_HUMAN 
Synonyms GRIP
Evidence Score (E-score) 3 Experimental Evidences +
1 Reconstituted Complex [93]
2 Reconstituted Complex [270]
3 Yeast two hybrid [93]
Interacting Protein Name Nibrin (NBN) Interacting Protein Interacting Protein Info
UniProt ID
NBN_HUMAN 
Synonyms AT.V1; AT.V2; ATV; NBS; NBS1; P95
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [271]
3 Yeast two hybrid [271]
Interacting Target Name S-phase kinase-associated protein 2 (SKP2) Literature-reported Target Interacting Protein Info
UniProt ID
SKP2_HUMAN 
Synonyms Skp2; P45skp2; FBXL1; F-box/LRR-repeat protein 1; F-box protein Skp2; Cyclin-A/CDK2-associated protein p45; Cyclin A/CDK2-associated protein p45; Cyclin A/CDK2-associated p45
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [272]
2 Reconstituted Complex [273]
Interacting Protein Name Nucleosome assembly protein 1-like 1 (NAP1L1) Interacting Protein Interacting Protein Info
UniProt ID
NP1L1_HUMAN 
Synonyms NAP1; NAP1L; NRP
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [274]
2 Yeast two hybrid [275]
References  Top
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REF 2 Pleiotropic effects of p300-mediated acetylation on p68 and p72 RNA helicase. J Biol Chem. 2010 Oct 1;285(40):30443-52.
REF 3 Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF. J Cell Biochem. 2007 Aug 1;101(5):1252-65.
REF 4 Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes. Mol Endocrinol. 2005 Oct;19(10):2451-65.
REF 5 Negative regulation of the p300-p53 interplay by DDX24. Oncogene. 2016 Jan 28;35(4):528-36.
REF 6 A multiprotein complex necessary for both transcription and DNA replication at the -globin locus. EMBO J. 2010 Oct 6;29(19):3260-71.
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REF 11 RANKL induces NFATc1 acetylation and stability via histone acetyltransferases during osteoclast differentiation. Biochem J. 2011 Jun 1;436(2):253-62.
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REF 30 Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism. J Biol Chem. 2005 Aug 19;280(33):29728-42.
REF 31 Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD. J Biol Chem. 2002 Mar 15;277(11):8847-53.
REF 32 p300 is required for orderly G1/S transition in human cancer cells. Oncogene. 2007 Jan 4;26(1):21-9.
REF 33 Acetylation control of the retinoblastoma tumour-suppressor protein. Nat Cell Biol. 2001 Jul;3(7):667-74.
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REF 36 SIRT1 deacetylates APE1 and regulates cellular base excision repair. Nucleic Acids Res. 2010 Jan;38(3):832-45.
REF 37 Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300. Mol Cell. 2001 Jun;7(6):1221-31.
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REF 40 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
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REF 43 Structural and Functional Impacts of ER Coactivator Sequential Recruitment. Mol Cell. 2017 Sep 7;67(5):733-743.e4.
REF 44 mTORC1 Phosphorylates Acetyltransferase p300 to Regulate Autophagy and Lipogenesis. Mol Cell. 2017 Oct 19;68(2):323-335.e6.
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REF 46 SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53. Cell. 2013 Jul 18;154(2):297-310.
REF 47 Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation. Nat Struct Mol Biol. 2013 Sep;20(9):1040-6.
REF 48 A novel estrogen receptor alpha-associated protein alters receptor-deoxyribonucleic acid interactions and represses receptor-mediated transcription. Mol Endocrinol. 2004 Nov;18(11):2649-59.
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REF 52 AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues. J Biol Chem. 2004 Apr 9;279(15):15630-8.
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REF 58 Crosstalk between CARM1 methylation and CBP acetylation on histone H3. Curr Biol. 2002 Dec 23;12(24):2090-7.
REF 59 Functional analysis of the p300 acetyltransferase domain: the PHD finger of p300 but not of CBP is dispensable for enzymatic activity. Nucleic Acids Res. 2001 Nov 1;29(21):4462-71.
REF 60 6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site. Eur J Med Chem. 2012 Jan;47(1):337-44.
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REF 62 Roles of coactivators in hypoxic induction of the erythropoietin gene. PLoS One. 2010 Apr 2;5(4):e10002.
REF 63 HIV-1 Tat interactions with p300 and PCAF transcriptional coactivators inhibit histone acetylation and neurotrophin signaling through CREB. J Biol Chem. 2005 Mar 11;280(10):9390-9.
REF 64 Sox9 and p300 cooperatively regulate chromatin-mediated transcription. J Biol Chem. 2005 Oct 21;280(42):35203-8.
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REF 68 Beta-HPV 5 and 8 E6 promote p300 degradation by blocking AKT/p300 association. PLoS Pathog. 2011 Aug;7(8):e1002211.
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REF 70 Role of Akt/protein kinase B in the activity of transcriptional coactivator p300. Cell Mol Life Sci. 2004 Jul;61(13):1675-83.
REF 71 MAPK p38 regulates transcriptional activity of NF-kappaB in primary human astrocytes via acetylation of p65. J Immunol. 2007 Nov 15;179(10):7101-9.
REF 72 Acetylation of a conserved lysine residue in the ATP binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes. Mol Cell Biol. 2011 Jun;31(11):2349-63.
REF 73 p300 Modulates the BRCA1 inhibition of estrogen receptor activity. Cancer Res. 2002 Jan 1;62(1):141-51.
REF 74 Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells. Oncogene. 2010 Jan 14;29(2):201-13.
REF 75 Cyclic changes in the expression of steroid receptor coactivators and corepressors in the normal human endometrium. J Clin Endocrinol Metab. 2003 Feb;88(2):871-8.
REF 76 Trichostatin A enhances acetylation as well as protein stability of ERalpha through induction of p300 protein. Breast Cancer Res. 2010;12(2):R22.
REF 77 SnoN oncoprotein enhances estrogen receptor- transcriptional activity. Cell Signal. 2012 Apr;24(4):922-30.
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