Protein-Protein Interaction Details
| Protein General Information | Top | ||||
|---|---|---|---|---|---|
| Full Name | DNA damage-binding protein 1 (DDB1) | ||||
| UniProt ID | DDB1_HUMAN | ||||
| Gene Name | DDB1 | ||||
| Gene ID | 1642 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Histone deacetylase 1 (HDAC1) | Target Info | PPI Info | [1] | |
| Interacting Literature-reported Target(s) | E3 ubiquitin-protein ligase COP1 (RFWD2) | Target Info | PPI Info | [2] | |
| Melanoma differentiation-associated protein 6 (CDKN1A) | Target Info | PPI Info | [5] | ||
| Interacting Clinical trial Target(s) | Checkpoint kinase-1 (CHK1) | Target Info | PPI Info | [3] | |
| Interacting Patented-recorded Target(s) | Dual-specificity tyrosine-phosphorylation regulated kinase 2 (DYRK2) | Target Info | PPI Info | [4] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | CRL4B interacts with and coordinates the SIN3A-HDAC complex to repress CDKN1A and drive cell cycle progression. J Cell Sci. 2014 Nov 1;127(Pt 21):4679-91. | ||||
| REF 2 | An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. J Cell Sci. 2009 Apr 1;122(Pt 7):1035-44. | ||||
| REF 3 | DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress. Cancer Res. 2009 Mar 15;69(6):2630-7. | ||||
| REF 4 | Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. Nat Cell Biol. 2009 Apr;11(4):409-19. | ||||
| REF 5 | PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Genes Dev. 2008 Sep 15;22(18):2496-506. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.