Target Interacting Protein Information
Target General Information | Top | ||||
---|---|---|---|---|---|
Target ID | T68547 | Target Info | |||
Target Name | Histone deacetylase 1 (HDAC1) | ||||
Synonyms | RPD3L1; HD1 | ||||
Target Type | Successful Target | ||||
Gene Name | HDAC1 | ||||
Biochemical Class | Carbon-nitrogen hydrolase | ||||
UniProt ID |
Target Interacting Proteins | Top | ||||
---|---|---|---|---|---|
Acid anhydride hydrolases | [+] 3 Acid anhydride hydrolases | + | |||
Interacting Protein Name | Chromodomain-helicase-DNA-binding protein 4 (CHD4) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CHD.4; Mi.2b; Mi2.BETA | ||||
Evidence Score (E-score) | 17 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [3] | |||
4 | Affinity Capture-MS | [4] | |||
5 | Affinity Capture-MS | [5] | |||
6 | Affinity Capture-MS | [6] | |||
7 | Affinity Capture-MS | [7] | |||
8 | Affinity Capture-MS | [8] | |||
9 | Affinity Capture-MS | [9] | |||
10 | Affinity Capture-Western | [10] | |||
11 | Affinity Capture-Western | [11] | |||
12 | Affinity Capture-Western | [6] | |||
13 | Affinity Capture-Western | [7] | |||
14 | Affinity Capture-Western | [9] | |||
15 | Affinity Capture-Western | [12] | |||
16 | Affinity Capture-Western | [13] | |||
17 | Reconstituted Complex | [9] | |||
Interacting Protein Name | Chromodomain-helicase-DNA-binding protein 3 (CHD3) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Mi.2a; Mi2.ALPHA; ZFH | ||||
Evidence Score (E-score) | 8 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [4] | |||
4 | Affinity Capture-MS | [5] | |||
5 | Affinity Capture-MS | [6] | |||
6 | Affinity Capture-Western | [10] | |||
7 | Affinity Capture-Western | [6] | |||
8 | Affinity Capture-Western | [14] | |||
Interacting Protein Name | Lymphoid-specific helicase (HELLS) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | LSH; PASG; SMARCA6 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [15] | |||
2 | Affinity Capture-Western | [16] | |||
3 | Co-localization | [15] | |||
Acyltransferases | [+] 2 Acyltransferases | + | |||
Interacting Target Name | Histone acetyltransferase p300 (EP300) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [17] | |||
2 | Affinity Capture-Western | [18] | |||
3 | Biochemical Activity | [19] | |||
4 | Reconstituted Complex | [18] | |||
Interacting Target Name | Transcription intermediary factor 1-beta (TRIM28) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Tripartite motif-containing protein 28; TIF1-beta; TIF1B; RNF96; RING-type E3 ubiquitin transferase TIF1-beta; RING finger protein 96; Nuclear corepressor KAP-1; KRIP-1; KRAB-interacting protein 1; KRAB-associated protein 1; KAP-1; KAP1; E3 SUMO-protein ligase TRIM28 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [20] | |||
2 | Affinity Capture-Western | [21] | |||
3 | Co-fractionation | [22] | |||
Beta-transducin repeats | [+] 4 Beta-transducin repeats | + | |||
Interacting Protein Name | Histone-binding protein RBBP4 (RBBP4) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | NURF55; RBAP48; lin.53 | ||||
Evidence Score (E-score) | 20 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [3] | |||
4 | Affinity Capture-MS | [4] | |||
5 | Affinity Capture-MS | [5] | |||
6 | Affinity Capture-MS | [6] | |||
7 | Affinity Capture-MS | [8] | |||
8 | Affinity Capture-MS | [9] | |||
9 | Affinity Capture-Western | [23] | |||
10 | Affinity Capture-Western | [24] | |||
11 | Affinity Capture-Western | [25] | |||
12 | Affinity Capture-Western | [26] | |||
13 | Affinity Capture-Western | [11] | |||
14 | Affinity Capture-Western | [6] | |||
15 | Affinity Capture-Western | [7] | |||
16 | Affinity Capture-Western | [9] | |||
17 | Affinity Capture-Western | [12] | |||
18 | Affinity Capture-Western | [27] | |||
19 | Affinity Capture-Western | [28] | |||
20 | Affinity Capture-Western | [29] | |||
Interacting Protein Name | Histone-binding protein RBBP7 (RBBP7) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | RbAp46 | ||||
Evidence Score (E-score) | 14 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [3] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [4] | |||
4 | Affinity Capture-MS | [6] | |||
5 | Affinity Capture-MS | [8] | |||
6 | Affinity Capture-MS | [9] | |||
7 | Affinity Capture-Western | [30] | |||
8 | Affinity Capture-Western | [24] | |||
9 | Affinity Capture-Western | [7] | |||
10 | Affinity Capture-Western | [9] | |||
11 | Affinity Capture-Western | [31] | |||
12 | Affinity Capture-Western | [32] | |||
13 | Co-fractionation | [33] | |||
14 | Co-purification | [34] | |||
Interacting Target Name | Embryonic ectoderm development protein (EED) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | WD protein associating with integrin cytoplasmic tails 1; WAIT-1; hEED; Embryonic ectoderm development protein | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [2] | |||
2 | Affinity Capture-Western | [35] | |||
Interacting Target Name | WD repeat-containing protein 5 (WDR5) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | BMP2-induced 3-kb gene protein; BIG3 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-Western | [36] | |||
Carbon-nitrogen hydrolases | [+] 2 Carbon-nitrogen hydrolases | + | |||
Interacting Target Name | Histone deacetylase 2 (HDAC2) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | HD2 | ||||
Evidence Score (E-score) | 20 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [3] | |||
4 | Affinity Capture-MS | [4] | |||
5 | Affinity Capture-MS | [6] | |||
6 | Affinity Capture-MS | [7] | |||
7 | Affinity Capture-MS | [9] | |||
8 | Affinity Capture-Western | [24] | |||
9 | Affinity Capture-Western | [37] | |||
10 | Affinity Capture-Western | [11] | |||
11 | Affinity Capture-Western | [38] | |||
12 | Affinity Capture-Western | [35] | |||
13 | Affinity Capture-Western | [6] | |||
14 | Affinity Capture-Western | [7] | |||
15 | Affinity Capture-Western | [8] | |||
16 | Affinity Capture-Western | [9] | |||
17 | Affinity Capture-Western | [39] | |||
18 | Affinity Capture-Western | [40] | |||
19 | Affinity Capture-Western | [41] | |||
20 | Affinity Capture-Western | [42] | |||
Interacting Target Name | Histone deacetylase 9 (HDAC9) | Patented-recorded Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | MITR; MEF2-interacting transcription repressor MITR; KIAA0744; Histone deacetylase-related protein; Histone deacetylase 7B; HDRP; HDAC7B; HDAC7; HD9; HD7b | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [43] | |||
2 | Reconstituted Complex | [44] | |||
Cell cycle related proteins | [+] 1 Cell cycle related proteins | + | |||
Interacting Target Name | G1/S-specific cyclin-D1 (CCND1) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | PRAD1 oncogene; PRAD1; Cyclin D1; BCL-1 oncogene; BCL-1; BCL1; B-cell lymphoma 1 protein | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [45] | |||
2 | Co-localization | [46] | |||
Cell division cycle proteins | [+] 1 Cell division cycle proteins | + | |||
Interacting Protein Name | Retinoblastoma-associated protein (RB1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | OSRC; PPP1R130; RB; p105.Rb; pRb; pp110 | ||||
Evidence Score (E-score) | 12 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [4] | |||
2 | Affinity Capture-Western | [47] | |||
3 | Affinity Capture-Western | [48] | |||
4 | Affinity Capture-Western | [49] | |||
5 | Affinity Capture-Western | [50] | |||
6 | Affinity Capture-Western | [51] | |||
7 | Affinity Capture-Western | [52] | |||
8 | Affinity Capture-Western | [53] | |||
9 | Affinity Capture-Western | [54] | |||
10 | Affinity Capture-Western | [55] | |||
11 | Reconstituted Complex | [56] | |||
12 | Reconstituted Complex | [50] | |||
Isomerases | [+] 2 Isomerases | + | |||
Interacting Target Name | DNA topoisomerase II alpha (TOP2A) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | TOP2; DNA topoisomerase II, alpha isozyme; DNA topoisomerase 2-alpha; DNA topoisomerase 2alpha | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [57] | |||
2 | Affinity Capture-Western | [58] | |||
3 | Reconstituted Complex | [58] | |||
Interacting Target Name | Mitochondrial matrix protein P1 (HSPD1) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | P60 lymphocyte protein; HuCHA60; HSP-60; Hsp60; Heat shock protein 60; CPN60; Chaperonin 60; 60 kDa heat shock protein, mitochondrial; 60 kDa chaperonin | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [2] | |||
2 | Affinity Capture-Western | [59] | |||
Kinases | [+] 2 Kinases | + | |||
Interacting Target Name | Casein kinase II alpha (CSNK2A1) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Protein kinase CK2; CK2A1; CK II alpha; CK II; Casein kinase II subunit alpha | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [25] | |||
2 | Biochemical Activity | [60] | |||
Interacting Protein Name | DDB1- and CUL4-associated factor 1 (DCAF1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | DCAF1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [61] | |||
2 | Reconstituted Complex | [62] | |||
Lyases | [+] 1 Lyases | + | |||
Interacting Protein Name | Chromodomain Y-like protein (CDYL) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CDYL1 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [2] | |||
2 | Affinity Capture-MS | [4] | |||
3 | Affinity Capture-Western | [63] | |||
Nuclear hormone receptors | [+] 4 Nuclear hormone receptors | + | |||
Interacting Target Name | Estrogen receptor (ESR) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER | ||||
Evidence Score (E-score) | 6 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [64] | |||
2 | Affinity Capture-Western | [65] | |||
3 | Affinity Capture-Western | [66] | |||
4 | Affinity Capture-Western | [67] | |||
5 | Co-localization | [68] | |||
6 | Reconstituted Complex | [65] | |||
Interacting Target Name | Glucocorticoid receptor (NR3C1) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Nuclear receptor subfamily 3 group C member 1; GRL; GR; Glucocorticoid receptor; Alpha-A | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [69] | |||
2 | Co-fractionation | [22] | |||
3 | Fluorescence Resonance Energy Transfer | [70] | |||
4 | Reconstituted Complex | [70] | |||
Interacting Target Name | Androgen receptor (AR) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Testosterone receptor; Nuclear receptor subfamily 3 group C member 4; NR3C4; Dihydrotestosterone receptor; DHTR; Androgen receptor | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [71] | |||
2 | Yeast two hybrid | [72] | |||
Interacting Target Name | Orphan nuclear receptor SHP (NR0B2) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Small heterodimer partner; SHP; Short heterodimer partner; Nuclear receptor subfamily 0 group B member 2 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [73] | |||
2 | Reconstituted Complex | [73] | |||
One-carbon transferases | [+] 5 One-carbon transferases | + | |||
Interacting Target Name | DNA [cytosine-5]-methyltransferase 1 (DNMT1) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | MCMT; M.HsaI; Dnmt1; DNMT; DNA MTase HsaI; DNA methyltransferase HsaI; DNA (cytosine-5)-methyltransferase 1; DNA (cytosine5)methyltransferase 1; CXXC-type zinc finger protein 9; CXXCtype zinc finger protein 9; CXXC9; AIM | ||||
Evidence Score (E-score) | 8 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [74] | |||
2 | Affinity Capture-Western | [75] | |||
3 | Affinity Capture-Western | [11] | |||
4 | Affinity Capture-Western | [76] | |||
5 | Affinity Capture-Western | [77] | |||
6 | Co-fractionation | [78] | |||
7 | Co-localization | [79] | |||
8 | Reconstituted Complex | [16] | |||
Interacting Target Name | DNA [cytosine-5]-methyltransferase 3B (DNMT3B) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | M.HsaIIIB; Dnmt3b; DNA MTase HsaIIIB; DNA methyltransferase HsaIIIB; DNA methyltransferase 3B; DNA (cytosine-5)-methyltransferase 3B | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [80] | |||
2 | Co-purification | [81] | |||
3 | Reconstituted Complex | [80] | |||
Interacting Target Name | Enhancer of zeste homolog 2 (EZH2) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Lysine N-methyltransferase 6; Lysine Nmethyltransferase 6; KMT6; Histone-lysine N-methyltransferase EZH2; Histonelysine Nmethyltransferase EZH2; EZH2 Y641N mutations; EZH2 Y641F mutations; ENX-1; ENX1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [82] | |||
2 | Co-fractionation | [83] | |||
Interacting Target Name | DNA [cytosine-5]-methyltransferase 3A (DNMT3A) | Patented-recorded Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | M.HsaIIIA; Dnmt3a; DNA MTase HsaIIIA; DNA methyltransferase HsaIIIA; DNA (cytosine-5)-methyltransferase 3A | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [84] | |||
2 | Reconstituted Complex | [84] | |||
Interacting Target Name | Mixed-lineage leukemia protein (MLL) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Zinc finger protein HRX; Trithorax-like protein; Trithoraxlike protein; p320; p180; Myeloid/lymphoid or mixed-lineage leukemia protein 1; Myeloid/lymphoid or mixed-lineage leukemia; MLL1; MLL cleavage product C180; Lysine N-methyltransferase 2A; Lysine Nmethyltransferase 2A; HTRX; HRX; Histonelysine Nmethyltransferase MLL; Histone-lysine N-methyltransferase 2A; CXXC-type zinc finger protein 7; CXXCtype zinc finger protein 7; CXXC7; ALL-1; ALL1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [85] | |||
2 | Reconstituted Complex | [85] | |||
Oxidoreductases | [+] 3 Oxidoreductases | + | |||
Interacting Target Name | Lysine-specific histone demethylase 1 (LSD) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Lysine-specific histone demethylase 1A; Lysinespecific histone demethylase 1A; LSD1; KIAA0601; KDM1; Flavin-containing amine oxidase domain-containing protein 2; Flavincontaining amine oxidase domaincontaining protein 2; BRAF35-HDAC complex protein BHC110; BRAF35HDAC complex protein BHC110; AOF2 | ||||
Evidence Score (E-score) | 14 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [3] | |||
4 | Affinity Capture-MS | [4] | |||
5 | Affinity Capture-MS | [5] | |||
6 | Affinity Capture-MS | [8] | |||
7 | Affinity Capture-Western | [86] | |||
8 | Affinity Capture-Western | [11] | |||
9 | Affinity Capture-Western | [8] | |||
10 | Affinity Capture-Western | [29] | |||
11 | Affinity Capture-Western | [87] | |||
12 | Affinity Capture-Western | [88] | |||
13 | Co-fractionation | [83] | |||
14 | Co-purification | [89] | |||
Interacting Target Name | Lysine-specific demethylase 5B (KDM5B) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Retinoblastoma-binding protein 2 homolog 1; Retinoblastomabinding protein 2 homolog 1; RBP2-H1; RBP2H1; RBBP2H1; PLU-1; PLU1; Lysinespecific demethylase 5B; Jumonji/ARID domain-containing protein 1B; Jumonji/ARID domaincontaining protein 1B; JARID1B; Histone demethylase JARID1B; CT31; Cancer/testis antigen 31 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [90] | |||
2 | Affinity Capture-Western | [91] | |||
3 | Reconstituted Complex | [90] | |||
Interacting Protein Name | C-terminal-binding protein 1 (CTBP1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | BARS | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [4] | |||
2 | Affinity Capture-Western | [92] | |||
3 | Reconstituted Complex | [93] | |||
Pore-forming toxins | [+] 1 Pore-forming toxins | + | |||
Interacting Target Name | Cellular tumor antigen p53 (TP53) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13 | ||||
Evidence Score (E-score) | 9 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [94] | |||
2 | Affinity Capture-Western | [95] | |||
3 | Affinity Capture-Western | [96] | |||
4 | Affinity Capture-Western | [97] | |||
5 | Biochemical Activity | [98] | |||
6 | Biochemical Activity | [99] | |||
7 | Biochemical Activity | [100] | |||
8 | Co-localization | [97] | |||
9 | Reconstituted Complex | [98] | |||
Transcription regulators | [+] 29 Transcription regulators | + | |||
Interacting Target Name | Metastasis associated gene-1 (MTA1) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Metastasis-associated protein MTA1; Metastasisassociated protein MTA1 | ||||
Evidence Score (E-score) | 13 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [3] | |||
4 | Affinity Capture-MS | [4] | |||
5 | Affinity Capture-MS | [5] | |||
6 | Affinity Capture-MS | [6] | |||
7 | Affinity Capture-MS | [7] | |||
8 | Affinity Capture-Western | [6] | |||
9 | Affinity Capture-Western | [11] | |||
10 | Co-fractionation | [83] | |||
11 | Co-fractionation | [33] | |||
12 | Co-localization | [68] | |||
13 | Reconstituted Complex | [101] | |||
Interacting Protein Name | Methyl-CpG-binding domain protein 2 (MBD2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | DMTase; NY.CO.41 | ||||
Evidence Score (E-score) | 9 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [3] | |||
4 | Affinity Capture-MS | [4] | |||
5 | Affinity Capture-MS | [8] | |||
6 | Affinity Capture-MS | [31] | |||
7 | Affinity Capture-Western | [31] | |||
8 | Affinity Capture-Western | [8] | |||
9 | Co-purification | [34] | |||
Interacting Protein Name | Methyl-CpG-binding domain protein 3 (MBD3) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Evidence Score (E-score) | 9 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [3] | |||
4 | Affinity Capture-MS | [4] | |||
5 | Affinity Capture-MS | [8] | |||
6 | Affinity Capture-Western | [11] | |||
7 | Affinity Capture-Western | [102] | |||
8 | Co-fractionation | [33] | |||
9 | Co-purification | [34] | |||
Interacting Protein Name | REST corepressor 1 (RCOR1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | COREST; RCOR | ||||
Evidence Score (E-score) | 9 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [3] | |||
4 | Affinity Capture-MS | [4] | |||
5 | Affinity Capture-MS | [8] | |||
6 | Affinity Capture-Western | [103] | |||
7 | Affinity Capture-Western | [26] | |||
8 | Affinity Capture-Western | [8] | |||
9 | Affinity Capture-Western | [29] | |||
Interacting Protein Name | Transcription factor p65 (RELA) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | NFKB3; p65 | ||||
Evidence Score (E-score) | 7 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [104] | |||
2 | Affinity Capture-Western | [105] | |||
3 | Affinity Capture-Western | [106] | |||
4 | Affinity Capture-Western | [107] | |||
5 | Affinity Capture-Western | [108] | |||
6 | Reconstituted Complex | [104] | |||
7 | Reconstituted Complex | [42] | |||
Interacting Protein Name | Zinc finger and BTB domain-containing protein 16 (ZBTB16) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | PLZF; ZNF145 | ||||
Evidence Score (E-score) | 7 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [109] | |||
2 | Affinity Capture-Western | [110] | |||
3 | Affinity Capture-Western | [111] | |||
4 | Reconstituted Complex | [109] | |||
5 | Reconstituted Complex | [112] | |||
6 | Reconstituted Complex | [113] | |||
7 | Reconstituted Complex | [114] | |||
Interacting Target Name | Hypoxia-inducible factor 1 alpha (HIF-1A) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein | ||||
Evidence Score (E-score) | 5 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [115] | |||
2 | Affinity Capture-Western | [116] | |||
3 | Affinity Capture-Western | [117] | |||
4 | Reconstituted Complex | [115] | |||
5 | Reconstituted Complex | [118] | |||
Interacting Protein Name | Breast cancer metastasis-suppressor 1 (BRMS1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Evidence Score (E-score) | 5 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [3] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [4] | |||
4 | Affinity Capture-Western | [119] | |||
5 | Affinity Capture-Western | [120] | |||
Interacting Protein Name | Mesoderm induction early response protein 1 (MIER1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | ER1; MI.ER1 | ||||
Evidence Score (E-score) | 5 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [3] | |||
4 | Affinity Capture-MS | [4] | |||
5 | Affinity Capture-Western | [121] | |||
Interacting Protein Name | Transcriptional repressor p66-alpha (GATAD2A) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | p66alpha | ||||
Evidence Score (E-score) | 5 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [3] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [4] | |||
4 | Co-fractionation | [33] | |||
5 | Reconstituted Complex | [122] | |||
Interacting Target Name | DNA-binding factor KBF1 (p105) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; Nuclear factor of kappa light polypeptide gene enhancer in Bcells 1; Nuclear factor NFkappaB p50 subunit; Nuclear factor NF-kappa-B p105 subunit; Nuclear factor NFkappaB p105 subunit; EBP-1; EBP1; DNA-binding factor KBF1; DNAbinding factor KBF1 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [104] | |||
2 | Affinity Capture-Western | [123] | |||
3 | Co-localization | [124] | |||
4 | Reconstituted Complex | [104] | |||
Interacting Protein Name | SMARCE1-related protein (HMG20B) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | BRAF25; BRAF35; HMGX2; HMGXB2; PP7706; SMARCE1r; SOXL; pp8857 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [3] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [4] | |||
4 | Affinity Capture-Western | [89] | |||
Interacting Protein Name | Transcriptional repressor p66-beta (GATAD2B) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | MRD18; P66beta; p68 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [3] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [4] | |||
4 | Reconstituted Complex | [122] | |||
Interacting Protein Name | PHD finger protein 21A (PHF21A) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | BHC80 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [4] | |||
4 | Reconstituted Complex | [125] | |||
Interacting Protein Name | REST corepressor 3 (RCOR3) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [3] | |||
4 | Affinity Capture-MS | [4] | |||
Interacting Protein Name | Deoxynucleotidyltransferase terminal-interacting protein 1 (DNTTIP1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | C20orf167; Tdif1; dJ447F3.4 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [3] | |||
4 | Affinity Capture-MS | [4] | |||
Interacting Target Name | Mothers against decapentaplegic homolog 7 (SMAD7) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Smad7; SMAD family member 7; SMAD 7; Mothers against DPP homolog 8; Mothers against decapentaplegic homolog 8; MAD homolog 8; hSMAD7 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [126] | |||
2 | Affinity Capture-Western | [127] | |||
3 | Reconstituted Complex | [126] | |||
Interacting Target Name | Transcription factor Sp1 (SP1) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | TSFP1 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [128] | |||
2 | Reconstituted Complex | [129] | |||
3 | Yeast two hybrid | [130] | |||
Interacting Target Name | Proto-oncogene c-Myc (MYC) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Transcription factor p64; Proto-oncogene c-Myc; Myc proto-oncogene protein; C-myc oncogene; C-myc; Class E basic helix-loop-helix protein 39; bHLHe39 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [2] | |||
2 | Affinity Capture-Western | [131] | |||
3 | Reconstituted Complex | [132] | |||
Interacting Target Name | Methyl cpg binding protein 2 (MECP2) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Methyl-CpG-binding protein 2; MethylCpGbinding protein 2; MeCp-2 protein; MeCp2 protein; MeCp2 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [133] | |||
2 | Affinity Capture-Western | [134] | |||
3 | Reconstituted Complex | [135] | |||
Interacting Protein Name | B-cell lymphoma 6 protein (BCL6) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | BCL5; BCL6A; LAZ3; ZBTB27; ZNF51 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [109] | |||
2 | Affinity Capture-Western | [136] | |||
3 | Reconstituted Complex | [137] | |||
Interacting Protein Name | High mobility group protein 20A (HMG20A) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | HMGX1; HMGXB1 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [3] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [4] | |||
Interacting Protein Name | DNA-binding protein Ikaros (IKZF1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Hs.54452; IK1; IKAROS; LYF1; LyF.1; PPP1R92; PRO0758; ZNFN1A1 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [4] | |||
2 | Affinity Capture-Western | [138] | |||
3 | Affinity Capture-Western | [139] | |||
Interacting Protein Name | Transcription factor PU.1 (SPI1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | OF; PU.1; SFPI1; SPI.1; SPI.A | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [140] | |||
2 | Affinity Capture-Western | [134] | |||
3 | Reconstituted Complex | [135] | |||
Interacting Target Name | Mothers against decapentaplegic homolog 3 (SMAD3) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | TGF-beta response effector Smad3; Smad3; SMAD family member 3; SMAD 3; Mothers against DPP homolog 3; MMad3; MADH3; Mad3; MAD homolog 3; JV15-2; HSMAD3; HMAD-3 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Reconstituted Complex | [141] | |||
2 | Yeast two hybrid | [142] | |||
Interacting Target Name | Hexamethylene bis-acetamide-inducible protein 1 (HEXIM1) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Protein HEXIM1; Menage a quatre 1; MAQ1; Likely ortholog of mouse cardiac lineage protein 1; HIS1 protein; HIS1; Hexamethylene bis-acetamide-inducible protein 1; Estrogen down-regulated gene 1 protein; CLP1; Cardiac lineage protein 1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [143] | |||
2 | Affinity Capture-Western | [117] | |||
Interacting Protein Name | B-cell lymphoma/leukemia 11B (BCL11B) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | ATL1; ATL1.alpha; ATL1.beta; ATL1.delta; ATL1.gamma; CTIP.2; CTIP2; RIT1; ZNF856B; hRIT1.alpha | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [4] | |||
2 | Reconstituted Complex | [144] | |||
Interacting Protein Name | Class E basic helix-loop-helix protein 41 (BHLHE41) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | BHLHB3; DEC2; SHARP1; hDEC2 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Co-localization | [145] | |||
2 | Reconstituted Complex | [146] | |||
Interacting Protein Name | Transcriptional repressor protein YY1 (YY1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | DELTA; INO80S; NF.E1; UCRBP; YIN.YANG.1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Co-localization | [147] | |||
2 | Reconstituted Complex | [148] | |||
Ubiquitin related proteins | [+] 1 Ubiquitin related proteins | + | |||
Interacting Target Name | Ubiquitin-protein ligase E3 Mdm2 (MDM2) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [149] | |||
2 | Co-localization | [71] | |||
3 | Reconstituted Complex | [149] | |||
Other proteins | [+] 23 Other proteins | + | |||
Interacting Protein Name | Paired amphipathic helix protein Sin3a (SIN3A) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Evidence Score (E-score) | 20 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [3] | |||
4 | Affinity Capture-MS | [4] | |||
5 | Affinity Capture-MS | [5] | |||
6 | Affinity Capture-MS | [6] | |||
7 | Affinity Capture-MS | [7] | |||
8 | Affinity Capture-MS | [9] | |||
9 | Affinity Capture-Western | [150] | |||
10 | Affinity Capture-Western | [26] | |||
11 | Affinity Capture-Western | [14] | |||
12 | Affinity Capture-Western | [7] | |||
13 | Affinity Capture-Western | [8] | |||
14 | Affinity Capture-Western | [9] | |||
15 | Affinity Capture-Western | [12] | |||
16 | Affinity Capture-Western | [27] | |||
17 | Affinity Capture-Western | [151] | |||
18 | Affinity Capture-Western | [28] | |||
19 | Affinity Capture-Western | [29] | |||
20 | Affinity Capture-Western | [133] | |||
Interacting Protein Name | Metastasis-associated protein MTA2 (MTA2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | MTA1L1; PID | ||||
Evidence Score (E-score) | 20 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [152] | |||
2 | Affinity Capture-MS | [1] | |||
3 | Affinity Capture-MS | [2] | |||
4 | Affinity Capture-MS | [3] | |||
5 | Affinity Capture-MS | [4] | |||
6 | Affinity Capture-MS | [5] | |||
7 | Affinity Capture-MS | [7] | |||
8 | Affinity Capture-MS | [8] | |||
9 | Affinity Capture-Western | [153] | |||
10 | Affinity Capture-Western | [26] | |||
11 | Affinity Capture-Western | [11] | |||
12 | Affinity Capture-Western | [8] | |||
13 | Affinity Capture-Western | [9] | |||
14 | Affinity Capture-Western | [29] | |||
15 | Affinity Capture-Western | [150] | |||
16 | Affinity Capture-Western | [32] | |||
17 | Co-fractionation | [22] | |||
18 | Co-fractionation | [83] | |||
19 | Co-fractionation | [33] | |||
20 | Co-purification | [34] | |||
Interacting Protein Name | Histone deacetylase complex subunit SAP30 (SAP30) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Evidence Score (E-score) | 12 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [3] | |||
4 | Affinity Capture-MS | [4] | |||
5 | Affinity Capture-MS | [6] | |||
6 | Affinity Capture-MS | [9] | |||
7 | Affinity Capture-Western | [154] | |||
8 | Affinity Capture-Western | [14] | |||
9 | Affinity Capture-Western | [9] | |||
10 | Affinity Capture-Western | [28] | |||
11 | Co-purification | [34] | |||
12 | Reconstituted Complex | [155] | |||
Interacting Protein Name | Paired amphipathic helix protein Sin3b (SIN3B) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Evidence Score (E-score) | 8 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [4] | |||
4 | Affinity Capture-MS | [5] | |||
5 | Affinity Capture-Western | [156] | |||
6 | Affinity Capture-Western | [8] | |||
7 | Co-fractionation | [83] | |||
8 | Co-purification | [34] | |||
Interacting Protein Name | Promyelocytic leukemia protein (PML) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | MYL; PP8675; RNF71; TRIM19 | ||||
Evidence Score (E-score) | 6 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [157] | |||
2 | Affinity Capture-Western | [158] | |||
3 | Affinity Capture-Western | [159] | |||
4 | Reconstituted Complex | [157] | |||
5 | Reconstituted Complex | [158] | |||
6 | Yeast two hybrid | [158] | |||
Interacting Protein Name | Inhibitor of growth protein 1 (ING1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | p24ING1c; p33; p33ING1; p33ING1b; p47; p47ING1a | ||||
Evidence Score (E-score) | 5 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [2] | |||
2 | Affinity Capture-MS | [4] | |||
3 | Affinity Capture-Western | [160] | |||
4 | Affinity Capture-Western | [154] | |||
5 | Affinity Capture-Western | [28] | |||
Interacting Protein Name | Metastasis-associated protein MTA3 (MTA3) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Evidence Score (E-score) | 5 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [3] | |||
4 | Affinity Capture-MS | [4] | |||
5 | Co-fractionation | [83] | |||
Interacting Protein Name | Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | DOC1; DORC1; ST19; doc.1; p12DOC.1 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [3] | |||
4 | Affinity Capture-MS | [4] | |||
Interacting Protein Name | ELM2 and SANT domain-containing protein 1 (ELMSAN1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | C14orf117; C14orf43; LSR68; c14_5541 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [3] | |||
4 | Affinity Capture-MS | [4] | |||
Interacting Protein Name | Genetic suppressor element 1 (GSE1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | KIAA0182 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [3] | |||
4 | Affinity Capture-MS | [4] | |||
Interacting Protein Name | Histone deacetylase complex subunit SAP130 (SAP130) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [4] | |||
4 | Affinity Capture-MS | [6] | |||
Interacting Protein Name | DNA damage-binding protein 1 (DDB1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | DDBA; UV.DDB1; XAP1; XPCE; XPE; XPE.BF | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [161] | |||
2 | Affinity Capture-Western | [61] | |||
3 | Reconstituted Complex | [162] | |||
Interacting Protein Name | T-complex protein 1 subunit alpha (TCP1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CCT.alpha; CCT1; CCTa; D6S230E; TCP.1.alpha | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [5] | |||
Interacting Target Name | Poly [ADP-ribose] polymerase 1 (PARP1) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Protein poly-ADP-ribosyltransferase PARP1; PPOL; Poly[ADP-ribose] synthetase-1; Poly[ADP-ribose] synthase 1; Poly(ADP-ribose)polymerase-1; PARP-1; NAD(+)Poly [ADP-ribose] polymerase-1 ADP-ribosyltransferase-1; NAD(+) ADP-ribosyltransferase-1; NAD(+) ADP-ribosyltransferase 1; DNA ADP-ribosyltransferase PARP1; ARTD1; ADPRT 1; ADPRT; ADP-ribosyltransferase diphtheria toxin-like 1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [163] | |||
2 | Biochemical Activity | [164] | |||
Interacting Target Name | Beta-catenin (CTNNB1) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [165] | |||
2 | Affinity Capture-Western | [166] | |||
Interacting Target Name | DNA [cytosine-5]-methyltransferase 3-like (DNMT3L) | Patented-recorded Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | DNA (cytosine-5)-methyltransferase 3-like | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [167] | |||
2 | Reconstituted Complex | [168] | |||
Interacting Target Name | von Hippel-Lindau disease tumor suppressor (VHL) | Patented-recorded Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | pVHL; Protein G7 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [169] | |||
2 | Reconstituted Complex | [118] | |||
Interacting Target Name | Maspin (SERPINB5) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Serpin B5; Protease inhibitor 5; PI-5; PI5; Peptidase inhibitor 5 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [170] | |||
2 | Yeast two hybrid | [171] | |||
Interacting Target Name | Vitamin D3 up-regulated protein 1 (VDUP1) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Vitamin D(3) up-regulating protein-1; Thioredoxin-interacting protein; Thioredoxin-binding protein 2 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [172] | |||
2 | Reconstituted Complex | [173] | |||
Interacting Target Name | Melanoma differentiation-associated protein 6 (CDKN1A) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | WAF1; SDI1; PIC1; P21(WAF1); P21; Melanoma differentiation associated protein 6; MDA-6; MDA6; Cyclin-dependent kinase inhibitor 1; CIP1; CDK-interacting protein 1; CAP20 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Co-localization | [174] | |||
2 | Reconstituted Complex | [175] | |||
Interacting Target Name | Prohibitin (PHB) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | PHB1; HEL-215; HEL-S-54e | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [176] | |||
2 | Reconstituted Complex | [177] | |||
Interacting Protein Name | Inhibitor of growth protein 2 (ING2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | ING1L; p33ING2 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [4] | |||
2 | Affinity Capture-Western | [154] | |||
Interacting Protein Name | T-complex protein 1 subunit theta (CCT8) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | C21orf112; Cctq; D21S246; PRED71 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [2] | |||
2 | Affinity Capture-MS | [5] |
References | Top | ||||
---|---|---|---|---|---|
REF 1 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
REF 2 | A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23. | ||||
REF 3 | Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Nat Biotechnol. 2011 Mar;29(3):255-65. | ||||
REF 4 | The functional interactome landscape of the human histone deacetylase family. Mol Syst Biol. 2013;9:672. | ||||
REF 5 | Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNA. PLoS Pathog. 2010 Jun 24;6(6):e1000965. | ||||
REF 6 | NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. Mol Cell. 1998 Dec;2(6):851-61. | ||||
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