Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Vascular endothelial growth factor receptor 2 (KDR) | Successful | Target Info | ||
| UniProt ID | VGFR2_HUMAN | ||||
| Gene Name | KDR | ||||
| Gene ID | 3791 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Vascular endothelial growth factor receptor 2 (KDR) | Target Info | PPI Info | [1] | |
| Vascular endothelial growth factor A (VEGFA) | Target Info | PPI Info | [2] | ||
| Vascular endothelial growth factor receptor 1 (FLT-1) | Target Info | PPI Info | [3] | ||
| Interacting Clinical trial Target(s) | Protein-tyrosine phosphatase SHP-2 (PTPN11) | Target Info | PPI Info | [4] | |
| Interacting Patented-recorded Target(s) | Protein-tyrosine phosphatase SHP-1 (PTPN6) | Target Info | PPI Info | [5] | |
| Interacting Literature-reported Target(s) | Signal transduction protein CBL (CBL) | Target Info | PPI Info | [6] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Anti-tumor effect of CT-322 as an adnectin inhibitor of vascular endothelial growth factor receptor-2. MAbs. 2010 Mar-Apr;2(2):199-208. | ||||
| REF 2 | ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165. J Biol Chem. 2003 Jun 27;278(26):23656-65. | ||||
| REF 3 | N-terminal cleavage and release of the ectodomain of Flt1 is mediated via ADAM10 and ADAM 17 and regulated by VEGFR2 and the Flt1 intracellular domain. PLoS One. 2014 Nov 11;9(11):e112794. | ||||
| REF 4 | Type I collagen limits VEGFR-2 signaling by a SHP2 protein-tyrosine phosphatase-dependent mechanism 1. Circ Res. 2006 Jan 6;98(1):45-54. | ||||
| REF 5 | TNFSF15 inhibits VEGF-stimulated vascular hyperpermeability by inducing VEGFR2 dephosphorylation. FASEB J. 2017 May;31(5):2001-2012. | ||||
| REF 6 | Shear Stress Regulates the Flk-1/Cbl/PI3K/NF-B Pathway Via Actin and Tyrosine Kinases. Cell Mol Bioeng. 2009 Sep 1;2(3):341-350. | ||||
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