Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T13057 Target Info
Target Name Protein-tyrosine phosphatase SHP-2 (PTPN11)
Synonyms Tyrosine-protein phosphatase non-receptor type 11; SHPTP2; SHP2; SHP-2; SH-PTP3; SH-PTP2; Protein-tyrosine phosphatase SHP2; Protein-tyrosine phosphatase 2C; Protein-tyrosine phosphatase 1D; PTP2C; PTP-2C; PTP-1D
Target Type Clinical trial Target
Gene Name PTPN11
Biochemical Class Phosphoric monoester hydrolase
UniProt ID
PTN11_HUMAN 
Target Interacting Proteins  Top
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name Growth factor receptor-bound protein 2 (GRB2) Interacting Protein Interacting Protein Info
UniProt ID
GRB2_HUMAN 
Synonyms SH2/SH3 adapter GRB2; Protein Ash; Growth factor receptor-bound protein 2; ASH; Adapter protein GRB2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Far Western [3]
4 Reconstituted Complex [4]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Target Name Caveolin 1 (CAV1) Literature-reported Target Interacting Protein Info
UniProt ID
CAV1_HUMAN 
Synonyms Caveolin-1; Caveolin1; Cav-1; CAV
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Reconstituted Complex [5]
Cytokine receptors [+] 1 Cytokine receptors +
Interacting Target Name Erythropoietin Receptor (EPOR) Successful Target Interacting Protein Info
UniProt ID
EPOR_HUMAN 
Synonyms Full-length form; EPO-R
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Reconstituted Complex [7]
Kinases [+] 11 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-Western [9]
3 Biochemical Activity [10]
4 Protein-peptide [11]
5 Yeast two hybrid [12]
Interacting Target Name Erbb2 tyrosine kinase receptor (HER2) Successful Target Interacting Protein Info
UniProt ID
ERBB2_HUMAN 
Synonyms Tyrosine kinase-type cell surface receptor HER2; Tyrosine kinase receptor ErbB2; Receptor tyrosine-protein kinase erbB-2; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; P185erbB2; NGL; NEU proto-oncogene; NEU; MLN19; MLN 19; Metastatic lymph node gene 19 protein; HER2/neu; HER2 (erbB2/neu); HER-2; Erb2; Epidermal growth factor receptor 2; C-erbB-2 oncoprotein; C-erbB-2; CD340
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-Western [13]
3 Protein-peptide [11]
4 Yeast two hybrid [12]
Interacting Target Name Vascular endothelial growth factor receptor 2 (KDR) Successful Target Interacting Protein Info
UniProt ID
VGFR2_HUMAN 
Synonyms VEGFR-2; VEGFR2; VEGF-2 receptor; Protein-tyrosine kinase receptor flk-1; Kinase insert domain receptor; FLK-1; FLK1; Fetal liver kinase 1; CD309
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Far Western [14]
3 Yeast two hybrid [12]
Interacting Target Name Insulin-like growth factor I receptor (IGF1R) Successful Target Interacting Protein Info
UniProt ID
IGF1R_HUMAN 
Synonyms Type 1 insulin-like growth factor receptor; Insulin-like growth factor 1 receptor; IGF-IR; IGF-I receptor; IGF-1R; IGF-1 receptor; CD221 antigen; CD221
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Reconstituted Complex [16]
3 Yeast two hybrid [12]
Interacting Target Name Erbb4 tyrosine kinase receptor (Erbb-4) Successful Target Interacting Protein Info
UniProt ID
ERBB4_HUMAN 
Synonyms Tyrosine kinase-type cell surface receptor HER4; Receptor tyrosine-protein kinase erbB-4; Proto-oncogene-like protein c-ErbB-4; P180erbB4; HER4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Yeast two hybrid [12]
Interacting Target Name Insulin receptor (INSR) Successful Target Interacting Protein Info
UniProt ID
INSR_HUMAN 
Synonyms IR; CD220 antigen; CD220
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Reconstituted Complex [18]
Interacting Target Name Janus kinase 2 (JAK-2) Successful Target Interacting Protein Info
UniProt ID
JAK2_HUMAN 
Synonyms Tyrosine-protein kinase JAK2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Biochemical Activity [4]
Interacting Target Name Tyrosine-protein kinase Kit (KIT) Successful Target Interacting Protein Info
UniProt ID
KIT_HUMAN 
Synonyms v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; Proto-oncogene tyrosine-protein kinase Kit; Proto-oncogene c-Kit; Piebald trait protein; PBT; p145 c-kit; Mast/stem cell growth factor receptor Kit; C-kit; CD117 antigen; CD117
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-peptide [20]
2 Reconstituted Complex [21]
Interacting Target Name Janus kinase 1 (JAK-1) Successful Target Interacting Protein Info
UniProt ID
JAK1_HUMAN 
Synonyms Tyrosine-protein kinase JAK1; JAK1B; JAK1A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [22]
2 Reconstituted Complex [4]
Interacting Target Name Erbb3 tyrosine kinase receptor (Erbb-3) Clinical trial Target Interacting Protein Info
UniProt ID
ERBB3_HUMAN 
Synonyms Tyrosine kinase-type cell surface receptor HER3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; HER3; C-erbB-3 protein; C-erbB3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Yeast two hybrid [12]
Interacting Target Name Ephrin type-A receptor 2 (EPHA2) Clinical trial Target Interacting Protein Info
UniProt ID
EPHA2_HUMAN 
Synonyms Tyrosine-protein kinase receptor ECK; Epithelial cell kinase; EphA2receptor; ECK
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [23]
2 Yeast two hybrid [12]
Other proteins [+] 7 Other proteins +
Interacting Target Name Vitamin D3 up-regulated protein 1 (VDUP1) Literature-reported Target Interacting Protein Info
UniProt ID
TXNIP_HUMAN 
Synonyms Vitamin D(3) up-regulating protein-1; Thioredoxin-interacting protein; Thioredoxin-binding protein 2
Evidence Score (E-score) 4 Experimental Evidences +
1 Co-crystal Structure [24]
2 Co-crystal Structure [25]
3 Reconstituted Complex [24]
4 Reconstituted Complex [25]
Interacting Target Name Insulin receptor substrate-1 (IRS1) Clinical trial Target Interacting Protein Info
UniProt ID
IRS1_HUMAN 
Synonyms IRS-1; Insulin receptor substrate 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [26]
2 Biochemical Activity [27]
3 Reconstituted Complex [28]
Interacting Target Name Platelet endothelial cell adhesion molecule (PECAM1) Literature-reported Target Interacting Protein Info
UniProt ID
PECA1_HUMAN 
Synonyms PECAM-1; PECA1; GPIIA'; EndoCAM; ECAM; CD31 antigen; CD31
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [29]
2 Far Western [30]
3 Reconstituted Complex [30]
Interacting Target Name Suppressor of cytokine signaling 3 (SOCS3) Literature-reported Target Interacting Protein Info
UniProt ID
SOCS3_HUMAN 
Synonyms STAT-induced STAT inhibitor 3; STAT induced STAT inhibitor 3; SSI-3; SSI3; SOCS-3; Cytokine-inducible SH2 protein 3; CIS-3; CIS3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [22]
2 Affinity Capture-Western [31]
3 Reconstituted Complex [22]
Interacting Target Name Proto-oncogene c-Crk (c-Crk) Literature-reported Target Interacting Protein Info
UniProt ID
CRK_HUMAN 
Synonyms P38; Adapter molecule crk
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [32]
2 Affinity Capture-Western [33]
Interacting Protein Name RNA polymerase-associated protein CTR9 homolog (CTR9) Interacting Protein Interacting Protein Info
UniProt ID
CTR9_HUMAN 
Synonyms SH2BP1; TSBP; p150; p150TSP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Proximity Label-MS [35]
Interacting Protein Name RNA polymerase II-associated factor 1 homolog (PAF1) Interacting Protein Interacting Protein Info
UniProt ID
PAF1_HUMAN 
Synonyms F23149_1; PD2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Proximity Label-MS [35]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk. J Biol Chem. 2000 Jun 9;275(23):17263-8.
REF 3 Direct binding of Shc, Grb2, SHP-2 and p40 to the murine granulocyte colony-stimulating factor receptor. Biochim Biophys Acta. 1998 Nov 19;1448(1):70-6.
REF 4 Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases. J Biol Chem. 1997 Jan 10;272(2):1032-7.
REF 5 SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes. PLoS One. 2014 Mar 14;9(3):e91582.
REF 6 Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis. Blood. 1996 Jun 1;87(11):4495-501.
REF 7 Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways. J Biol Chem. 1995 Mar 10;270(10):5631-5.
REF 8 Phosphotyrosine interactome of the ErbB-receptor kinase family. Mol Syst Biol. 2005;1:2005.0008.
REF 9 Association of SH2 domain protein tyrosine phosphatases with the epidermal growth factor receptor in human tumor cells. Phosphatidic acid activates receptor dephosphorylation by PTP1C. J Biol Chem. 1995 Sep 8;270(36):21277-84.
REF 10 Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584. Cell Growth Differ. 1996 Dec;7(12):1589-97.
REF 11 A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature. 2006 Jan 12;439(7073):168-74.
REF 12 A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Mol Cell. 2017 Jan 19;65(2):347-360.
REF 13 Differential signaling by the epidermal growth factor-like growth factors neuregulin-1 and neuregulin-2. J Biol Chem. 1998 Oct 9;273(41):26954-61.
REF 14 Type I collagen limits VEGFR-2 signaling by a SHP2 protein-tyrosine phosphatase-dependent mechanism 1. Circ Res. 2006 Jan 6;98(1):45-54.
REF 15 Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility. Mol Cell Biol. 1999 Apr;19(4):3125-35.
REF 16 Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating protein. J Biol Chem. 1995 Aug 11;270(32):19151-7.
REF 17 Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction. J Biol Chem. 1995 Dec 8;270(49):29189-93.
REF 18 Insulin receptor kinase phosphorylates protein tyrosine phosphatase containing Src homology 2 regions and modulates its PTPase activity in vitro. Biochem Biophys Res Commun. 1994 Mar 15;199(2):780-5.
REF 19 SHPTP2 serves adapter protein linking between Janus kinase 2 and insulin receptor substrates. Biochem Biophys Res Commun. 1996 Nov 1;228(1):122-7.
REF 20 The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit. Biochem J. 2003 Mar 15;370(Pt 3):1033-8.
REF 21 The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells. J Biol Chem. 1994 Oct 7;269(40):25206-11.
REF 22 SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130. J Biol Chem. 2003 Jan 3;278(1):661-71.
REF 23 Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation. Nat Cell Biol. 2000 Feb;2(2):62-9.
REF 24 Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP. Biochem J. 2016 Jan 15;473(2):179-87.
REF 25 Structural basis for a novel interaction between TXNIP and Vav2. FEBS Lett. 2016 Mar;590(6):857-65.
REF 26 The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling. J Biol Chem. 1998 Oct 9;273(41):26908-14.
REF 27 The Protein-tyrosine-phosphatase SHP2 is phosphorylated on serine residues 576 and 591 by protein kinase C isoforms alpha, beta 1, beta 2, and eta. Biochemistry. 2002 Jan 15;41(2):603-8.
REF 28 The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp. J Biol Chem. 1993 Jun 5;268(16):11479-81.
REF 29 Platelet-endothelial cell adhesion molecule-1 (CD31), a scaffolding molecule for selected catenin family members whose binding is mediated by different tyrosine and serine/threonine phosphorylation. J Biol Chem. 2000 Jul 14;275(28):21435-43.
REF 30 Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma1 with PECAM-1/CD31. FEBS Lett. 1999 Apr 30;450(1-2):77-83.
REF 31 SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130. J Biol Chem. 2000 Apr 28;275(17):12848-56.
REF 32 Charting the molecular network of the drug target Bcr-Abl. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7414-9.
REF 33 Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk. J Biol Chem. 1999 Sep 3;274(36):25726-34.
REF 34 SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver. Mol Cell. 2011 Jul 8;43(1):45-56.
REF 35 Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. Cell Rep. 2016 Nov 22;17(9):2488-2501.

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