Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T56510 | Target Info | |||
| Target Name | Apoptosis regulator Bcl-xL (BCL-xL) | ||||
| Synonyms |
Bcl2like protein 1; Bcl2L1; Bcl2-L-1; Bcl-XL; Bcl-2-like protein 1; BCLX; BCL2L; Apoptosis regulator Bcl-X
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|
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| Target Type | Clinical trial Target | ||||
| Gene Name | BCL2L1 | ||||
| Biochemical Class | B-cell lymphoma Bcl-2 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 70 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Resveratrol
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|
Phase 3 | Compound Info | ||
| Synonyms |
Resveratrol; Resvida; KUC104385N; R 5010; SRT 501; Cis-resveratrol; PREVENTION 8 (RESVERATROL); RM-1812; SRT-501; Trans-resveratrol; CU-01000001503-3; KSC-10-164; Resveratrol-3-sulfate; Trans-3,4',5-trihydroxystilbene; Trans-3,4′,5-Trihydroxystilbene; Trans-1,2-(3,4',5-Trihydroxydiphenyl)ethylene; (E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol
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|
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| Activity |
IC50 = 190000 nM
|
[1] | |||
| Compound Name |
SAR-405838
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|
Phase 1 | Compound Info | ||
| Synonyms |
AT-219; MI-147; MI-219; MI-319; MI-43; MI-5; MI-63; MI-772; MI-773; MI-519-64; P53-HDM2 protein interaction inhibitors (cancer); P53-HDM2 protein interaction inhibitors (cancer), Ascenta/Sanofi; P53-HDM2 protein interaction inhibitors (cancer), Ascenta/sanofi-aventis
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
4-((E)-(((E)-2-(Cyclohexylimino)-4-methylthiazol-3(2h)-yl)imino)methyl)benzene-1,2,3-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3265288; SCHEMBL14680218; SCHEMBL15266339; SCHEMBL15266342; SYN5101; HMS1752D04; ZINC4498172; 3852AH; BDBM50013890; AKOS024458334; ZINC101116763; CS-3227; AS-16465; HY-16695; A16315; SR-01000043908; SR-01000043908-1; 1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(2S)-3-(4-Bromophenyl)-N-(4-chloro-3-nitrophenyl)sulfonyl-2-[(5Z)-5-[[4-(4-nitrophenyl)phenyl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3401814; BDBM50067366
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|
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| Activity |
Ki = 50000 nM
|
[4] | |||
| Compound Name |
6-Chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-N-[3-[(2-methylpropanoylamino)methyl]phenyl]sulfonyl-7-(1,3,5-trimethylpyrazol-4-yl)-1H-indole-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3785461; BDBM50159953
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|
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| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
N-[4-[[(2R)-4-(Dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonyl-4-(3-phenyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL373713
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| Activity |
EC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
N-[5-(Benzylcarbamoyl)furan-2-yl]sulfonyl-6-chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-7-(1,3,5-trimethylpyrazol-4-yl)-1H-indole-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3786325; BDBM50159956
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| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
6-Chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-N-[3-[[(1-methylpyrrole-2-carbonyl)amino]methyl]phenyl]sulfonyl-7-(1,3,5-trimethylpyrazol-4-yl)-1H-indole-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3787158; BDBM50160061
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|
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| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
Piperazine analogue, 22
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL437146; BDBM21409
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|
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| Activity |
EC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(2S)-2-[(4S)-4-[[4-(4-Chlorophenyl)phenyl]methyl]-2,5-dioxoimidazolidin-1-yl]-N-(3-nitrophenyl)sulfonyl-3-phenylpropanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629657; BDBM50130040
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|
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| Activity |
Ki ~ 50000 nM
|
[7] | |||
| Compound Name |
5-[(E)-(2-Cyclohexylimino-4-methyl-1,3-thiazol-3-yl)iminomethyl]benzene-1,2,3-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4072989; SCHEMBL15279229; BDBM380478; US9926306, ID 183-84
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|
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
(2S)-2-[(4S)-4-[[4-(3-Methylphenyl)phenyl]methyl]-2,5-dioxoimidazolidin-1-yl]-N-(4-methylphenyl)sulfonyl-3-phenylpropanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629659; BDBM50130041
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| Activity |
Ki ~ 50000 nM
|
[7] | |||
| Compound Name |
6-Chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-N-[5-(pyridin-4-ylmethylcarbamoyl)furan-2-yl]sulfonyl-7-(1,3,5-trimethylpyrazol-4-yl)-1H-indole-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3786057; SCHEMBL19503557; BDBM50159993
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|
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| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
(2S)-N-(4-Chloro-3-nitrophenyl)sulfonyl-2-[(4S)-4-[[4-(4-formylphenyl)phenyl]methyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylpropanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629661; BDBM50130043
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|
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| Activity |
Ki ~ 50000 nM
|
[7] | |||
| Compound Name |
4-[8-Ethylsulfanyl-3-(4-hydroxyphenyl)-3-methyloctan-4-yl]phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2374449; BDBM50024671
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|
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| Activity |
Ki = 58900 nM
|
[9] | |||
| Compound Name |
N-[4-[[(2S)-4-(Dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonyl-4-[2-methoxy-4-(3-morpholin-4-ylpropyl)phenyl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL202964; BDBM50181893
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|
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| Activity |
EC50 = 59200 nM
|
[10] | |||
| Compound Name |
2-[3-[(Z)-[5-(2-Methoxyphenyl)-3-oxo-7-phenyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-2-ylidene]methyl]phenoxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094444; BDBM50318209
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| Activity |
IC50 = 72000 nM
|
[11] | |||
| Compound Name |
2,3,8-Trihydroxy-9-oxo-9H-benzocycloheptene-6-carboxylic acid ethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL135650; BDBM50133353
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|
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| Activity |
IC50 = 73000 nM
|
[12] | |||
| Compound Name |
(R)-4-(4-(Dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrobenzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2063881; SCHEMBL376632; BDBM50388981; ZINC65740484
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|
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| Activity |
Ki = 75000 nM
|
[13] | |||
| Compound Name |
(-)-Marinopyrrole A
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|
Investigative | Compound Info | ||
| Synonyms |
Marinopyrrole A; Maritoclax; (-)-Maritoclax; Marinopyrrole A (Maritoclax); CHEMBL3393621; SCHEMBL12320854; EX-A4638; BDBM50266967; s7126; ZINC43207346; AKOS025293495; CCG-269775; CS-1973; AK547121; BS-14779; HY-15613; B1080; Q27135298; Maritoclax; (inverted exclamation markA)-Marinopyrrole
Click to Show/Hide
|
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| Activity |
IC50 ~ 80000 nM
|
[14] | |||
| Compound Name |
5-(4-Chlorophenyl)-1,2-dimethyl-N-[3-(4-methylpiperazin-1-yl)propyl]-4-phenylpyrrole-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159733; BDBM50393835
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|
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| Activity |
Ki = 88000 nM
|
[15] | |||
| Compound Name |
2-[1-Hydroxy-4-(thiophen-2-ylsulfonylamino)naphthalen-2-yl]sulfanylacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2030270; SCHEMBL2244145; BDBM50013839; CCG-23228; STK918344; MCULE-1114821633; EU-0048437; 2-(1-hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-ylthio)acetic acid; ({1-hydroxy-4-[(thiophen-2-ylsulfonyl)amino]naphthalen-2-yl}sulfanyl)acetic acid
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| Activity |
Ki = 99000 nM
|
[3] | |||
| Compound Name |
(4R,4As,6aR,6aS,6bR,8aR,12aR,14bR)-2,2,6a,6b,9,9,12a-heptamethyl-4-(3-methylbut-2-enoyloxy)-10-oxo-3,4,5,6,6a,7,8,8a,11,12,13,14b-dodecahydro-1H-picene-4a-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL555367; Lantadene B; BDBM50295311
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|
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| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
6-[8-(1,3-Benzothiazol-2-ylcarbamoyl)imidazo[1,2-a]pyridin-2-yl]pyridine-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3287291; BDBM50020928
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|
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| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
(1S,2S,3R,6R,7R,10S,11S,12S)-2-[3-(3,4-Dihydroxyphenyl)propyl]tetracyclo[8.2.1.03,12.06,11]trideca-4,8-diene-7-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3298854; BDBM50022583
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|
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| Activity |
Ki ~ 100000 nM
|
[18] | |||
| Compound Name |
2-[3-[(Z)-[11-(2-Methoxyphenyl)-13-oxo-5-phenylmethoxy-15-thia-12,17-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(10),2(7),3,5,16-pentaen-14-ylidene]methyl]phenoxy]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094643; BDBM50318206
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
1-(2-Ethoxyphenyl)-2-[3-methyl-5-oxo-1-(4-phenyl-1,3-thiazol-2-yl)-4H-pyrazol-4-yl]ethane-1,2-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3417401; BDBM50078021
Click to Show/Hide
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| Activity |
Ki ~ 100000 nM
|
[19] | |||
| Compound Name |
2-[3-[4-(Dimethylamino)phenyl]-5-hydroxyphenyl]-4-[(2-ethoxyphenyl)diazenyl]-5-methyl-1H-pyrazol-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3417402; BDBM50078022
Click to Show/Hide
|
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| Activity |
Ki ~ 100000 nM
|
[19] | |||
| Compound Name |
(1S,2S,3R,6R,7R,10S,11S,12S)-2-[3-(4-Hydroxyphenyl)propyl]tetracyclo[8.2.1.03,12.06,11]trideca-4,8-diene-7-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3298851; BDBM50022566
Click to Show/Hide
|
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| Activity |
Ki ~ 100000 nM
|
[18] | |||
| Compound Name |
2-(3-((Z)-((E)-9-(3-Fluorobenzylidene)-5-(3-fluorophenyl)-3-oxo-3,5,6,7,8,9-hexahydro-2H-thiazolo[2,3-b]quinazolin-2-ylidene)methyl)-phenoxy)acetic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094645; BDBM50318208
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(2R,3R,3As,9bS)-N-((S)-1-benzylpyrrolidin-3-yl)-1-(cyclohexylmethyl)-3-(hydroxymethyl)-6-oxo-2,3,3a,4,6,9b-hexahydro-1H-pyrrolo[2,3-a]indolizine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL467508; BDBM50259503
Click to Show/Hide
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| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
1-O-[alpha-L-(Rhamnopyranosyl]-23-acetoxyimberbic acid 29-methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL542004; BDBM50295306
Click to Show/Hide
|
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| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
4-[2-(2-Ethoxyphenyl)acetyl]-5-methyl-2-(4-phenyl-1,3-thiazol-2-yl)-4H-pyrazol-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3417400; BDBM50078020
Click to Show/Hide
|
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| Activity |
Ki ~ 100000 nM
|
[19] | |||
| Compound Name |
2-[3-[(Z)-[8-Methoxy-11-(2-methoxyphenyl)-13-oxo-15-thia-12,17-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(10),2,4,6,16-pentaen-14-ylidene]methyl]phenoxy]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094443; BDBM50318205
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
5-Propan-2-yl-2-pyrrolidin-1-yl-7-(2-pyrrolidin-1-ylquinolin-3-yl)quinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2171509; BDBM50397583
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| Activity |
EC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
2-[3-[(Z)-[11-(2-Methoxyphenyl)-13-oxo-5-(2-phenylbenzoyl)oxy-15-thia-12,17-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(10),2(7),3,5,16-pentaen-14-ylidene]methyl]phenoxy]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094644; BDBM50318207
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
2-[4-[1-[2-[4-(Carboxymethylsulfanyl)-2-hydroxybenzoyl]-4,5-dichloro-1H-pyrrol-3-yl]-4,5-dichloropyrrole-2-carbonyl]-3-hydroxyphenyl]sulfanylacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393633; SCHEMBL15919803; BDBM50303762
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
23-Acetoxyimberbic acid 29-methyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL558462; BDBM50295303
Click to Show/Hide
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| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
4-(2,2-Diphenylethylidene)-5-methyl-2-(4-phenylthiazol-2-yl)-2,4-dihydro-3H-pyrazol-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3417396; BDBM50078016
Click to Show/Hide
|
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| Activity |
Ki ~ 100000 nM
|
[19] | |||
| Compound Name |
(2S,3S,3Ar,9bR)-2-(4-benzylpiperidine-1-carbonyl)-1-(3,4-dichlorobenzyl)-3-(hydroxymethyl)-2,3,3a,4-tetrahydro-1H-pyrrolo[2,3-a]indolizin-6(9bH)-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL506763; BDBM50259507
Click to Show/Hide
|
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| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
2-[3-(3-Aminophenyl)-5-hydroxyphenyl]-4-[(2-ethoxyphenyl)diazenyl]-5-methyl-1H-pyrazol-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3417406; BDBM50078026
Click to Show/Hide
|
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| Activity |
Ki ~ 100000 nM
|
[19] | |||
| Compound Name |
4-[(2-Ethoxyphenyl)diazenyl]-2-(3-hydroxy-5-thiophen-2-ylphenyl)-5-methyl-1H-pyrazol-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3417405; BDBM50078025
Click to Show/Hide
|
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| Activity |
Ki ~ 100000 nM
|
[19] | |||
| Compound Name |
(S,Z)-2-(5-((6-(3,4-Dimethoxyphenyl)pyridin-3-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL596599; SCHEMBL19425336; BDBM50308111
Click to Show/Hide
|
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| Activity |
Ki ~ 100000 nM
|
[22] | |||
| Compound Name |
4-[5-Propan-2-yl-7-(2-propoxyquinolin-3-yl)quinolin-2-yl]morpholine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2171506; BDBM50397584
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(2R,3R,3As,9bS)-1-(cyclohexylmethyl)-3-(hydroxymethyl)-6-oxo-N-(4-phenoxybenzyl)-2,3,3a,4,6,9b-hexahydro-1H-pyrrolo[2,3-a]indolizine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL470541; BDBM50259506
Click to Show/Hide
|
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| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
2-Hydroxy-3,4,6-trimethoxy-benzocyclohepten-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL133255; CTK2E3478; DTXSID40466984; BDBM50133356; 5H-Benzocyclohepten-5-one, 2-hydroxy-3,4,6-trimethoxy-
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(2R,3R,3As,9bS)-1-(cyclohexylmethyl)-N-(2,3-dihydro-1H-inden-2-yl)-3-(hydroxymethyl)-6-oxo-2,3,3a,4,6,9b-hexahydro-1H-pyrrolo[2,3-a]indolizine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL467709; BDBM50259504
Click to Show/Hide
|
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| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
(1S,9R,10R,11R)-12-[4-(4-Chlorophenyl)-5-phenyl-1,3-thiazol-2-yl]-10-(hydroxymethyl)-N-(2-methoxyethyl)-6-oxo-7,12-diazatricyclo[7.2.1.02,7]dodeca-2,4-diene-11-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL502454; BDBM50259501
Click to Show/Hide
|
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| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
1-O-[alpha-L-(Rhamnopyranosyl]-23-acetoxy-3beta-acetylimberbic acid 29-methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL553855; BDBM50295308
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
4-[3-(5-Propan-2-yl-2-propoxyquinolin-7-yl)quinolin-2-yl]morpholine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2171491; BDBM50397585
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
2-[3-[4-(Dimethylamino)phenyl]phenyl]-4-[(2-ethoxyphenyl)diazenyl]-5-methyl-1H-pyrazol-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3417408; BDBM50078028
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[19] | |||
| Compound Name |
(E)-3-[(1S,2R,3S,4S,5S,7R,8R,9R)-4-[3-(4-Hydroxyphenyl)propyl]-8-tetracyclo[5.4.0.02,5.03,9]undec-10-enyl]prop-2-enoic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3299034; BDBM50022655
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||||
| Activity |
Ki ~ 100000 nM
|
[18] | |||
| Compound Name |
Ethyl 2-[3-[(Z)-[11-(2-methoxyphenyl)-13-oxo-15-thia-12,17-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(10),2,4,6,16-pentaen-14-ylidene]methyl]phenoxy]acetate
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1097427; BDBM50318194
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||||
| Activity |
IC50 = 100000 nM
|
[11] | |||
| Compound Name |
(1R,9S,10S,11S)-12-[4-(4-Chlorophenyl)-5-phenyl-1,3-thiazol-2-yl]-10-(hydroxymethyl)-N-(2-methoxyethyl)-6-oxo-7,12-diazatricyclo[7.2.1.02,7]dodeca-2,4-diene-11-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL506360; BDBM50259502
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||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
2,3,4,6-Tetramethoxybenzo[7]annulen-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL134871; 2,3,4,6-tetramethoxy-5H-benzo[7]annulen-5-one; Purpurogallin tetramethyl ether; NSC52570; Spectrum_001940; SpecPlus_000490; Spectrum5_001688; ChemDiv2_001976; 2,3,4,6-Tetramethoxy-benzocyclohepten-5-one; Oprea1_001909; KBioSS_002492; MLS001048925; DivK1c_006586; SCHEMBL12171162; CTK5B5808; KBio1_001530; KBio2_002485; KBio2_005053; KBio2_007621; ZINC56820; DTXSID80284104; HMS1374J18; HMS2268J06; NSC35623; BDBM50133358; NSC-35623; NSC-52570; STK235005; AKOS000525526; MCULE-2860542554; SMR000387113; ST50167780; 2,7,8,9-tetramethoxybenzo[a][7]annulen-1-one; AB00052896-09; 2,3,4,6-Tetramethoxy-5H-benzocyclohepten-5-one; SR-01000323883; 5H-Benzocyclohepten-5-one,2,3,4,6-tetramethoxy-; SR-01000323883-1; BRD-K78848902-001-07-8
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
3-[5-[(Z)-[11-(3-Fluorophenyl)-8-methoxy-13-oxo-15-thia-12,17-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(10),2,4,6,16-pentaen-14-ylidene]methyl]furan-2-yl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095311; BDBM50318216
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Lantadene A
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Rehmannic acid; UNII-9SK62WCU1W; 9SK62WCU1W; HSDB 3503; 22-beta-Angeloyloxyoleanolic acid; Olean-12-en-28-oic acid, 22-beta-hydroxy-3-oxo-, 2-methylcrotonate, (Z)-; Olean-12-en-28-oic acid, 22beta-hydroxy-3-oxo-, 2-methylcrotonate, (Z)-; 22-((2-Methyl-1-oxo-2-butenyl)oxy)-3-oxo-olean-12-en-28-oic acid, 22-beta(Z)-; CHEMBL510691; ZINC42835006; 22-((2-Methyl-1-oxo-2-butenyl)oxy)-3-oxo-olean-12-en-28-oic acid, (22beta); Q27273075
Click to Show/Hide
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||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
(E)-4-(2-(2-Ethoxyphenyl)hydrazono)-3-methyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-5(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BAM 7; BAX Activator Molecule 7; BAM-7; CHEMBL3417395; CHEMBL3187660; SCHEMBL16266654; SCHEMBL16266655; DTXSID00420906; BCP07775; EX-A1937; ZINC6631357; 2248AH; BDBM50078015; s7105; AKOS000582957; AKOS001611624; AKOS026750495; ZINC100510737; ZINC299848298; CCG-268710; CS-1453; MCULE-7761312742; SB19400; NCGC00347939-01; AC-32082; AK260848; AS-55800; BP-25406; HY-15341; AB0165650; A12907; W-5259; J-019031
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[19] | |||
| Compound Name |
(2S,3S,3Ar,9bR)-2-(4-benzylpiperidine-1-carbonyl)-3-(hydroxymethyl)-1-(4-phenoxybenzyl)-2,3,3a,4-tetrahydro-1H-pyrrolo[2,3-a]indolizin-6(9bH)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL509472; BDBM50259509
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
(2S,3S,3Ar,9bR)-1-(3,4-dichlorobenzyl)-2-(4-(4-fluorophenyl)piperidine-1-carbonyl)-3-(hydroxymethyl)-2,3,3a,4-tetrahydro-1H-pyrrolo[2,3-a]indolizin-6(9bH)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL510828; BDBM50259508
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||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
1-Epi-Meiogynin A
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL550027; BDBM50295163
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[23] | |||
| Compound Name |
4-[(2-Ethoxyphenyl)diazenyl]-2-(3-hydroxy-5-phenylphenyl)-5-methyl-1H-pyrazol-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3417403; BDBM50078023
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[19] | |||
| Compound Name |
(2R,3R,3As,9bS)-N-((R)-1-benzylpyrrolidin-3-yl)-1-(cyclohexylmethyl)-3-(hydroxymethyl)-6-oxo-2,3,3a,4,6,9b-hexahydro-1H-pyrrolo[2,3-a]indolizine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL467309; BDBM50259505
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
(2S,3S,3Ar,9bR)-2-(4-(4-fluorophenyl)piperidine-1-carbonyl)-3-(hydroxymethyl)-1-(4-phenoxybenzyl)-2,3,3a,4-tetrahydro-1H-pyrrolo[2,3-a]indolizin-6(9bH)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL501793; BDBM50259510
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
3-(5-((Z)-((E)-9-(3-Fluorobenzylidene)-5-(3-fluorophenyl)-3-oxo-3,5,6,7,8,9-hexahydro-2H-thiazolo[2,3-b]quinazolin-2-ylidene)methyl)-furan-2-yl)benzoic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095312; BDBM50318217
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
3-[5-[(E)-N-Benzamido-C-methylcarbonimidoyl]furan-2-yl]benzoic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2398281; BDBM50436629
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||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
4-(4-Chlorophenyl)-1-[(3s)-3,4-Dihydroxybutyl]-N-[3-(4-Methylpiperazin-1-Yl)propyl]-3-Phenyl-1h-Pyrrole-2-Carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2063880; BDBM50388980; Q27458226; B50
Click to Show/Hide
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||||
| Activity |
Ki = 138000 nM
|
[25] | |||
| Compound Name |
4-Phenoxy-N-(4-phenylphenyl)sulfonylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824810; BDBM50352176
Click to Show/Hide
|
||||
| Activity |
IC50 = 161300 nM
|
[26] | |||
| Compound Name |
4-[[(2R)-4-(Dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitro-N-phenylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2063890; SCHEMBL12685615; BDBM50388978
Click to Show/Hide
|
||||
| Activity |
Ki = 166000 nM
|
[13] | |||
| Compound Name |
4,4-Bis(4-chlorophenyl)-3-butenyldimethylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL332055; BDBM50149240; [4,4-Bis-(4-chloro-phenyl)-but-3-enyl]-dimethyl-amine
Click to Show/Hide
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||||
| Activity |
IC50 = 180000 nM
|
[27] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 13 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Ent-17-Hydroxytrachyloban-18-oic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1165508; BDBM50321033
Click to Show/Hide
|
||||
| Activity |
IC50 = 220000 nM
|
[28] | |||
| Compound Name |
Benzo[b]thiophene-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
Thianaphthene-2-carboxylic acid; Benzo(b)thiophene-2-carboxylic acid; 1-Benzothiophene-2-carboxylic acid; Thionaphthene-2-carboxylic acid; Benzothiophene-2-carboxylic acid; 2-benzo[b]thiophenecarboxylic acid; UNII-HLR49221FQ; MFCD00051636; CHEMBL312607; HLR49221FQ; benzothiophene 2 carboxylic acid; Thionapthene-2-carboxylic acid; BL-5583; Thianaphthene-2-carboxylicacid; 2-Benzothiophenecarboxylic acid; NSC 40258; zlchem 823; ACMC-20airt; NSC 112990; 2-Carboxybenzothiophene; Maybridge1_002631; SCHEMBL93858; benzothiophene carboxylic acid; DivK1c_001383; benzo[b]thiophenecarboxylic acid; benzothiophen-2-carboxylic acid; benzothiophene 2-carboxylic acid; HMS548P13; KS-00000CCD; ZINC42511; DTXSID60212485; ZLD0284; ALBB-032943; NSC40258; ANW-75255; BDBM50149218; GEO-02293; NSC-40258; NSC112990; SBB003763; STL353601; 1-Benzothiophene-2-carboxylic acid #; AKOS000266073; Thianaphthene-2-carboxylic acid, 98%; CS-W004876; FS-1519; LS40345; MCULE-6165149428; NSC-112990; SDCCGMLS-0065962.P001; CDS1_000343; NCGC00339347-01; AC-22600; AK-27833; BR-27833; SC-13722; ST019994; SY003106; AB0002497; DB-007270; FT-0601179; EN300-13076; M-2653; AB01332017-02; 314B289; J-640122; J-800126; W-200470; W-204306; Q27279999; Z89265777; F2191-0022
Click to Show/Hide
|
||||
| Activity |
Ki = 230000 nM
|
[29] | |||
| Compound Name |
3-Chloro-6-methylbenzo[b]thiophene-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-chloro-6-methyl-1-benzothiophene-2-carboxylic acid; 3-Chloro-6-methylbenzothiophene-2-carboxylic acid; 3-Chloro-6-methyl-benzo[b]thiophene-2-carboxylic acid; CHEMBL2314523; ACMC-20an6a; CBMicro_023300; SCHEMBL417349; CTK1C0981; DTXSID10355679; ZINC327857; ACT07951; ALBB-000953; 4179AB; BBL013609; BDBM50424723; CCG-10571; GEO-00712; MFCD00687576; SBB006957; STK372259; AKOS000267335; MCULE-3549045158; VS-03886; BIM-0023181.P001; ST45231718; EN300-69909; W-7481; 3-CHLORO-6-METHYLBENZO(B)THIOPHENE-2-CA&; AG-690/36719028; SR-01000412394; 3-Chloro-6-methylbenzo thiophene-2-carboxylic acid; SR-01000412394-1; W-200316; 3-chloro-6-methylbenzo [b]thiophene-2-carboxylic acid; 3-chloro-6-methylbenzo[b]thio-phene-2-carboxylic acid; Benzo[b]thiophene-2-carboxylicacid, 3-chloro-6-methyl-; Z228588844; 3-Chloro-6-methylbenzo[b]thiophene-2-carboxylic acid, 97%; (2-METHOXYCARBONYL)PHENYL-2-,3,4,6-TETRA-O-ACETYL-BETA-D-GLUCOPYRANOSE
Click to Show/Hide
|
||||
| Activity |
Ki = 230000 nM
|
[29] | |||
| Compound Name |
Ent-16alpha-Hydroxykaur-11-en-18-oic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1165054; BDBM50321034
Click to Show/Hide
|
||||
| Activity |
IC50 = 380000 nM
|
[28] | |||
| Compound Name |
Ent-Trachyloban-18-oic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1164460; BDBM50321035
Click to Show/Hide
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||||
| Activity |
IC50 = 400000 nM
|
[28] | |||
| Compound Name |
3-(3,4-Dimethoxyphenyl)-N-(4-phenoxyphenyl)sulfonylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824822; BDBM50352188
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[26] | |||
| Compound Name |
3,7-Dimethyl-benzofuran-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3,7-dimethyl-1-benzofuran-2-carboxylic acid; 3,7-dimethylbenzofuran-2-carboxylic acid; CHEMBL2314507; SCHEMBL11748492; CTK7J1247; DTXSID40390336; ZINC4502750; 5405AD; BDBM50424722; AKOS000360032; MCULE-7987044630; NE30358; NCGC00327699-01; ST086603; 3,7-dimethylbenzo[b]furan-2-carboxylic acid; EN300-53340; AB01323190-02; 3,7-dimethyl-1-benzofuran-2-carboxylic acid, AldrichCPR; F2169-0501; Z803145518
Click to Show/Hide
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||||
| Activity |
Ki > 1000000 nM
|
[29] | |||
| Compound Name |
3-(1-Naphthylmethylsulfanyl)-1H-1,2,4-triazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2314513; 5-[(1-naphthylmethyl)sulfanyl]-1H-1,2,4-triazole; ZINC3176387; BDBM50424717; STK978340; AKOS000616471; AKOS001624374; MCULE-5838210029; AF-399/37297047; SR-01000429828; SR-01000429828-1; 5-((naphthalen-1-ylmethyl)thio)-1H-1,2,4-triazole; 1H-1,2,4-Triazole, 3-[(1-naphthalenylmethyl)thio]-; 3-[(naphthalen-1-ylmethyl)sulfanyl]-4H-1,2,4-triazole; F0910-1198
Click to Show/Hide
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||||
| Activity |
Ki > 1000000 nM
|
[29] | |||
| Compound Name |
3-(4-Chloro-3,5-dimethylphenoxy)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2314512; BDBM50424718; ZINC11800214; AKOS000299971
Click to Show/Hide
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||||
| Activity |
Ki > 1000000 nM
|
[29] | |||
| Compound Name |
7-Methyl-3-phenyl-1H-indole-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2314511; SCHEMBL3611265; BDBM50424720; STK319198; ZINC12650903; AKOS002291834; CCG-279122; MCULE-2613330604; 7-methyl-3-phenylindole-2-carboxylic acid; ST50781354
Click to Show/Hide
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||||
| Activity |
Ki > 1000000 nM
|
[29] | |||
| Compound Name |
3,6,7-Trimethyl-benzofuran-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3,6,7-trimethyl-1-benzofuran-2-carboxylic acid; CHEMBL2314508; 3,6,7-trimethylbenzo[b]furan-2-carboxylic acid; CTK7J1246; DTXSID00424464; ZINC4502658; 1401AF; BDBM50424721; SBB027848; STK522124; AKOS000301965; MCULE-2119528168; NCGC00322626-01; ST090114; 3,6,7-Trimethylbenzofuran-2-carboxylic acid; AB01266325-03; BRD-K77466920-001-01-1; Z57904574; F2169-0516
Click to Show/Hide
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||||
| Activity |
Ki > 1000000 nM
|
[29] | |||
| Compound Name |
(4-Chloro-3-methylphenoxy)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(4-chloro-3-methylphenoxy)acetic acid; (4-Chloro-3-methyl-phenoxy)-acetic acid; Acetic acid, (4-chloro-3-methylphenoxy)-; 4-chloro-3-methylphenoxyacetic acid; CHEMBL177299; BRN 1963793; Acetic acid, ((4-chloro-m-tolyl)oxy)-; NSC30119; 4-06-00-02065 (Beilstein Handbook Reference); ARONIS004021; SCHEMBL7493102; CTK5A8926; KS-00003WVV; ZINC38647; DTXSID10207523; 3-methyl-4-chlorophenoxyacetic acid; ALBB-000819; 6151AE; BBL014307; BDBM50424719; MFCD01671841; NSC-30119; SBB009311; STK003435; AKOS000114558; MCULE-5714027283; (4-Chloro-3-methyl-phenoxy)acetic acid; ST054900; VS-04261; AB0153761; BB 0244018; FT-0677822; EN300-00114; W-8530; AN-329/40159148; SR-01000430139; J-501384; SR-01000430139-1; (4-chloro-3-methyl-phenoxy)-acetic acid, AldrichCPR; Z56823032; F0722-7382
Click to Show/Hide
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||||
| Activity |
Ki > 1000000 nM
|
[29] | |||
| Compound Name |
3,4-Dichloro-1-benzothiophene-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
3,4-dichlorobenzo[b]thiophene-2-carboxylic acid; CHEMBL1612421; 3,4-Dichloro-benzo[b]thiophene-2-carboxylic acid; CBMicro_018065; Cambridge id 6131552; MLS000713830; SCHEMBL1520807; CTK4H2632; DTXSID80356057; HMS2634J24; HMS3363L17; ZINC334753; ALBB-000958; 1010AE; BBL037293; BDBM50424724; CCG-14224; MFCD00617272; SBB039152; STK398090; AKOS000267334; MCULE-9931805377; DA-24760; SC-41294; SMR000273311; VS-14047; BIM-0018114.P001; BB 0256751; FT-0678485; R3534; ST50007713; EN300-30747; 3,4-dichlorobenzo [b]thiophene-2-carboxylic acid; Benzo[b]thiophene-2-carboxylic acid, 3,4-dichloro-; Z228589014
Click to Show/Hide
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||||
| Activity |
Ki > 1000000 nM
|
[29] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention. J Med Chem. 2010 May 27;53(10):3899-906. | ||||
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| REF 3 | 3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation. J Med Chem. 2014 May 22;57(10):4111-33. | ||||
| REF 4 | Design, synthesis and preliminary bioactivity studies of 2-thioxo-4-thiazolidinone derivatives as Bcl-2 inhibitors. Bioorg Med Chem. 2015 May 1;23(9):1994-2003. | ||||
| REF 5 | Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods. J Med Chem. 2016 Mar 10;59(5):2054-66. | ||||
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| REF 8 | Expanding the Cancer Arsenal with Targeted Therapies: Disarmament of the Antiapoptotic Bcl-2 Proteins by Small Molecules. J Med Chem. 2017 Feb 9;60(3):821-838. | ||||
| REF 9 | Structure-activity relationship studies of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an antagonist for antiapoptotic Bcl-2 proteins to overcome drug resistance in cancer. J Med Chem. 2006 Dec 28;49(26):7731-9. | ||||
| REF 10 | Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo. J Med Chem. 2006 Feb 9;49(3):1165-81. | ||||
| REF 11 | Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors. J Med Chem. 2010 May 13;53(9):3465-79. | ||||
| REF 12 | Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins. J Med Chem. 2003 Sep 25;46(20):4259-64. | ||||
| REF 13 | Design of Bcl-2 and Bcl-xL inhibitors with subnanomolar binding affinities based upon a new scaffold. J Med Chem. 2012 May 24;55(10):4664-82. | ||||
| REF 14 | Small-molecule Mcl-1 inhibitors: Emerging anti-tumor agents. Eur J Med Chem. 2018 Feb 25;146:471-482. | ||||
| REF 15 | Structure-based design of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity. J Med Chem. 2012 Jul 12;55(13):6149-61. | ||||
| REF 16 | Cytotoxic pentacyclic triterpenoids from Combretum sundaicum and Lantana camara as inhibitors of Bcl-xL/BakBH3 domain peptide interaction. J Nat Prod. 2009 Jul;72(7):1314-20. | ||||
| REF 17 | Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL. ACS Med Chem Lett. 2014 Mar 21;5(6):662-7. | ||||
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